1.A Case of Masked t(8;21) in Acute Myeloid Leukemia with Cytogenetic Abnormality of 45,X,-Y,t(8;17)(q22;p13).
Laboratory Medicine Online 2011;1(3):168-171
The t(8;21)(q22;q22) is one of the most frequent structural chromosomal anomaly found in AML, occurring in about 5% of all AML and in 10% of AML with maturation (M2). And approximately 3.4% of AML with t(8;21)(q22;q22) occurs as a complex chromosomal abnormality and occasionally shows discrepancy between cytogenetic and molecular genetic analyses. We report a case of 42 yr old male patient that revealed morphological characteristics of AML-M2 and karyotypic abnormality of 45,X,-Y,t(8;17)(q22;p13) without visible involvement of chromosome 21 by conventional cytogenetic study with masked t(8;21) identified by FISH using RUNX1/RUNX1T1 probes. FISH confirmed nuc ish (RUNX1T1x3),(RUNX1x3), (RUNX1T1 con RUNX1x1). According to the results of conventional cytogenetic and FISH analyses, the karyotype was revised to 45,X,-Y,t(8;17;21)(q22;p13;q22).
Chromosome Aberrations
;
Chromosomes, Human, Pair 21
;
Cytogenetics
;
Humans
;
Karyotype
;
Leukemia, Myeloid, Acute
;
Male
;
Masks
;
Molecular Biology
2.Localized Pigmented Villonodular Synovitis of the Posterior Compartment of the Knee: A Case Report.
Hyun Kee CHUNG ; Choong Hyeok CHOI ; Kyeong Jin CHOI ; Seong Pil LEE
The Journal of the Korean Orthopaedic Association 1998;33(1):211-215
Localized pigmented villonodular synovitis is a monoarticular proliferative condition that may affect any joint but is frequently found in the knee. The locaiized form was less frequent than the diffuse one. The estimated frequency of localized pigmented villonodular synovitis among patients performed an arthroscopic procedure was known one case lor each 2,500 cases. Previous reports pointed that the lower recurrence rate after the arthroscopic excision for localized form. We also experienced a case of localized pigmented viilonodular synovitis located at the posterior compartment of the knee, so we report this case with review of literatures.
Humans
;
Joints
;
Knee*
;
Recurrence
;
Synovitis
;
Synovitis, Pigmented Villonodular*
3.Arthroscopic Synovectomy in the Rheumatoid Arthritis of the Knee Joint.
Hyun Kee CHUNG ; Choong Hyeok CHOI ; Young Joon CHOI ; Kyeong Jin CHOI ; Jae Min LEE
The Journal of the Korean Orthopaedic Association 1998;33(2):264-272
The short term beneficial effect of arthroscopic excision of synovial tissue in knees with rheumatoid arthritis have been well documented. The purpose of this study to report the results of synovectomy in patients with rheumatoid arthritis who have been observed at least 3 years. We analysed the clinical result with modified Laurin criteria, radiologic change and patients own satisfaction degree with survey. The results were as follows; 1. The preoperative symptoms were pain (100%), swelling (100%), decreased range of motion (83%) and joint tenderness (74%), and those were improved postoperatively to 43%, 60%, 11%, 43% each other. 2. Among the laboratory parameters, C-reactive protein (CRP) was improved most significantly (pvalue =0.026). 3. On simple supine A-P X-rays, the width of medial joint space and lateral joint space were compared to preoperatively and postoperatively. The width of medial joint space was 4.33mm preoperatively, and it was changed to 3.22mm at last follow up (p=0.032). Those of lateral joint space was changed from 4.24mm preoperatively to 3.27mm at last tollow up (p=0.106). 4. The grade of articular cartilage damage was related with severity of preoperative symptoms and the patients with low grade of articular cartilage damage showed more postoperative improvement. The result of operation was related to symptom duration, degree of X-ray change and degree of cartilage damage. 5. 58% ot patients were satisfied to results of synovectomy, 28% were answered neither satisfied nor ansatisfied and 14% were unsatisf'ied to operation. We concluded the arthroscopic synovectomy of the knee joints was effective procedure to improve the clinical symptoms, range of knee motion and to alleviate the inflammatory reaction at mid-term period al'ter the operation. So we consider this procedure is a palliative treatment that modified and alleviate the progression of rheumatoid arthritis of knee joints.
Arthritis, Rheumatoid*
;
C-Reactive Protein
;
Cartilage
;
Cartilage, Articular
;
Follow-Up Studies
;
Humans
;
Joints
;
Knee Joint*
;
Knee*
;
Palliative Care
;
Range of Motion, Articular
4.Neuropsychological profiles and their correlation to motor symptoms in newly diagnosed Parkinsondisease patients with mild cognitive impairment
Eun Joo Chung ; Jae-Hyeok Lee ; Kyngha Seok ; Sang Jin Kim
Neurology Asia 2014;19(1):19-25
Background & Objectives: Frontal executive dysfunction, which is hypothesized to reflect dorsolateral
prefrontal function, predominates in Parkinson’s disease (PD). Visuospatial dysfunction and episodic
memory deficit, which are associated with the posterior cortical area, are critical symptoms of mild
cognitive impairment in PD (PD-MCI). The first aim of this study is to investigate whether dominant
cognitive deficits are caused by posterior cortical dysfunction in drug naïve, de novo PD-MCI patients.
The second aim is to analyze the relationship between parkinsonian motor symptoms and the cognitive
domain in these patients. Methods: Newly diagnosed PD patients who had not received treatment were
divided into two subgroups as follows: PD-MCI (n=39) and PD patients with normal cognition (PD-NC)
(n=39). Various neuropsychological tests were performed in all of the patients. The parkinsonian motor
subscores were divided into tremor, rigidity, axial impairment, bulbar dysfunction and bradykinesia
by the UPDRS motor scores. Results: Verbal episodic memory (immediate recall; p = 0.0001, delayed
recall; p = 0.0001, recognition; p = 0.003), visual episodic memory (immediate recall; p = 0.0001,
delayed recall; p = 0.002) and visuospatial function (p = 0.046) were lower in the PD-MCI group
than in the PD-NC group. In the analysis of the correlation of the motor components to the cognitive
tests, impairment in visual episodic memory correlated with axial symptoms (immediate recall; r =
-0.441, p = 0.021, delayed recall; r = -0.393, p = 0.042). The contrast program test correlated with
bradykinesia (r = -0.479, p = 0.013)
Conclusion: Episodic memory and visuospatial dysfunction, which reflect impairment of the posterior
cortical area, are critical cognitive deficits, and memory impairment is correlated with the axial symptoms
that are associated with non-dopaminergic pathways in newly diagnosed PD-MCI patients.
5.Behavioral and psychological symptoms in Korean patients with mild Alzheimer’s disease: Preliminary study
Soo-Ji Lee ; Jae-Hyeok Heo ; Hee-Tae Kim ; Jin-Young Ahn
Neurology Asia 2013;18(1):65-71
Behavioral and psychological symptoms of dementia are major components of Alzheimer’s disease.
In this study, we aimed at investigating the prevalence and severity of behavioral and psychological
symptoms of dementia in very mild to mild Alzheimer’s disease. Forty-four patients with Alzheimer’s
disease who visited the neurology outpatient clinic of Seoul Medical Center were included. A trained
neurologist or a supervised test technician administered the neuropsychological test, the Seoul
Neuropsychological Screening Battery including Mini Mental State Examination and Clinical Dementia
Rating. The instrument used for assessing behavioral and psychological symptoms of dementia was
Neuropsychiatric Inventory-Questionnaire. In order of prevalence, apathy, depression, irritability,
anxiety, and agitation were the most common symptoms occurring in very mild-to-mild Alzheimer’s
disease group. The prevalence and severity of behavioral and psychological symptoms of dementia
were found to be in positive correlation with the Clinical Dementia Rating scores. Behavioral and
psychological symptoms of dementia are found even in the very early stage of Alzheimer’s disease,
apathy and depression being the most common symptoms. Physicians should be aware of this when
managing dementia patients.
6.Operative treatment of supracondylar-Condylar Fractures of the Femur
Jin Hwan AHN ; Myung Chul YOU ; Suck Hyun LEE ; Hyun Soo KIM ; Shin Hyeok KANG
The Journal of the Korean Orthopaedic Association 1976;11(4):700-708
The previous reports about Supracondylar-Condylar Fracture of the femur which extends to articular surfaces revealed poor results in general, regardless of the methods of treatment. But those results are thought to be much alleviated if they are treated according to the principles of ASIF. Fifteen cases of Supracondylar-condylar fractures of the femur from 13 patients were treated by open reduction and rigid internal fixation during last 3 years at Department of Orthopedic Surgery, Early mobilization of knee joint was permissible in most of the cases without loss of fixation or other complications during convalescence Subsequently, greatifying results were obtained as observed in varying period of follow up days.
Convalescence
;
Early Ambulation
;
Femur
;
Follow-Up Studies
;
Humans
;
Knee Joint
;
Orthopedics
7.Histological Changes Induced by Neurolysis: An Experimental Study on Rabbit Sciatic Nerve
Jin Hwan AHN ; Myung Chul YOO ; Shin Hyeok KANG ; Young Girl LEE
The Journal of the Korean Orthopaedic Association 1982;17(1):1-11
Several attempts have been made to assess the relative importance of the vasa nervorum and the intrinsic longitudinal vascular plexuses of nerve in maintaining the blood supply of a segment of nerve trunk, but the effect of mobilization on the ability of an injuried or repaired nerve to regenerate and regain function has been less certain and is the subject of these investigations. Thirty-two Korean rabbits of both sexes were used for these studies and we concluded that it is increased fibrosis with adhesion to surrounded tissues, loss of glistening and milk-like discoloration of never grossly, and increased degeneration and milk-like discoloration of nerve grossly, and increased degeneration of axons and demyelization progressively and early proliferated Schwann cells with increasing length of neurolysis. And there was no recovery of damage in nerve tissue induced by above 7 cm of neurolysis. (1:35)
Axons
;
Fibrosis
;
Nerve Tissue
;
Rabbits
;
Schwann Cells
;
Sciatic Nerve
;
Vasa Nervorum
8.A Case of Lymphangiomas(So-called Combined Venous Lymphatic Malformation) Resulting in Orbital Abscess.
Ja Heon KANG ; Jong Hyeok LEE ; Kyung Hyun JIN ; Ju Hie LEE
Journal of the Korean Ophthalmological Society 1999;40(2):603-607
Orbital lymphangiomas are benign vascular hamartomas that may be found in the conjunctiva, the eyelids, the orbit, or elsewhere in the head and neck region. Deep lymphangiomatous lesions are classically characterized by acute onset of a fulminant proptosis resulting from spontaneous hemorrhage within the orbit. Complete surgical excision is often difficult because of the infiltrative nature of the tumor.We report one case of lymphangiomas considered to be associated with cavernous hemangioma which could not be removed completely by several surgical excisions and was exenterated because of orbital abscess of unknown origin and septic condition.
Abscess*
;
Conjunctiva
;
Exophthalmos
;
Eyelids
;
Hamartoma
;
Head
;
Hemangioma, Cavernous
;
Hemorrhage
;
Lymphangioma
;
Neck
;
Orbit*
9.Septic Knee Arthritis Caused by Group B Salmonella Species in a Patient with Systemic Lupus Erythematosus.
Choong Hyeok CHOI ; Rae Hyung LEE ; Jin Kyu LEE
The Journal of the Korean Orthopaedic Association 2011;46(4):340-344
Infection is a leading cause of death in patients with systemic lupus erythematosus (SLE). Insufficiency of the reticuloendothelial system, immunosuppressive therapy and inadequate opsonization are the main predisposing factors for infection. Salmonella infection is one of the most common opportunistic bacterial infections in patients with SLE and it can provoke a bacteremia or a localized infection. We report here on a rare case of septic knee arthritis caused by Group B Salmonella in a SLE patient, and this was treated with arthroscopic irrigation and antibiotics.
Anti-Bacterial Agents
;
Arthritis
;
Arthritis, Infectious
;
Bacteremia
;
Bacterial Infections
;
Cause of Death
;
Humans
;
Knee
;
Lupus Erythematosus, Systemic
;
Mononuclear Phagocyte System
;
Salmonella
;
Salmonella Infections
10.A Splenectomy in Plasma Exchange Refractory Thrombotic Thrombocytopenia Purpura.
Young Jin LEE ; Hyeok SHIM ; Dong Eun PARK
The Korean Journal of Laboratory Medicine 2006;26(2):119-122
Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, and variable abnormalities in renal function and mental status. The pathogenesis of TTP is related to an inhibitor or deficiency of the von Willebrand factor (vWF)-cleaving protease (a disintegrin and metalloprotease with thrombospondin type 1 repeats; ADAMTS-13) that cleaves the large vWF multimers. Uncleaved, large vWF molecules are present in TTP and induce thrombosis in small vessels. Even though plasma exchange was proven effective in TTP, 20-40% of the cases showed refractory to plasma exchange. We describe a 41 years old female with plasma exchange refractory TTP who was completely recovered from anemia, thrombocytopenia, and accompanying symptoms following splenectomy.
Adult
;
Anemia
;
Anemia, Hemolytic
;
Female
;
Fever
;
Humans
;
Plasma Exchange*
;
Plasma*
;
Purpura*
;
Purpura, Thrombotic Thrombocytopenic
;
Splenectomy*
;
Thrombocytopenia*
;
Thrombosis
;
Thrombospondins
;
von Willebrand Factor