No abstract available.
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use ; Crohn Disease/*complications/*drug therapy ; Female ; Humans ; Intestinal Obstruction/*etiology ; Male

MicroRNAs (miRNAs) are recently discovered non-coding small RNAs that play a role as regulators of genetic expressions in eukaryotic cells. It comprises about 20 nucleotides, which contains seed sequence to bind 3'-untranslated lesion of specific target mRNA. It regulates self-renewal, proliferation and differentiation via post-transcriptional gene slicing in normal situation. Aberrant expressions of miRNAs are observed in many cancers as well. miRNAs in cancer cells have been investigated extensively to have a role in tumorigenesis, invasion, metastasis and chemoresistance. In cancer cells, miRNAs act both as tumor suppressors or oncogenes by doing down-regulation of oncogenes or up-regulation of tumor suppressors, respectively. This suggests miRNAs can be potential therapeutic and diagnostic targets in cancers. Pancreatic cancer is one of the most lethal tumors. In spite of many efforts, overall 5-year survival rate of pancreatic cancer is still very low (<5%). Recently, several miRNAs as an oncomir (acting like oncogenes or tumor suppressor genes) are discovered in pancreatic cancer. Here, the role of miRNAs in pancreatic cancer will be discussed and its possibility of diagnostic/therapeutic target will be also mentioned.
Epithelial-Mesenchymal Transition ; Humans ; MicroRNAs/*metabolism ; Neoplasm Metastasis ; Pancreatic Neoplasms/diagnosis/*metabolism ; Prognosis

No abstract available.
Acupuncture Therapy/*adverse effects ; Acute Disease ; Amylases/blood ; Humans ; Lipase/blood ; Male ; Middle Aged ; Pancreatitis/*diagnosis/etiology ; Tomography, X-Ray Computed

No abstract available.
Acupuncture Therapy/*adverse effects ; Acute Disease ; Amylases/blood ; Humans ; Lipase/blood ; Male ; Middle Aged ; Pancreatitis/*diagnosis/etiology ; Tomography, X-Ray Computed

No abstract available.

No abstract available.

Numerous medications have the potential to induce acute pancreatitis. However, isoniazid-induced acute pancreatitis is extremely rare. Drug-induced acute pancreatitis can be diagnosed by improvement after stopping the drug and recurrence of pancreatitis when rechallenged. We present a case of severe acute pancreatitis accompanied by multiple large pseudocysts after isoniazid treatment for pulmonary tuberculosis. We confirmed that isoniazid induced pancreatitis by rechallenging after treatment cessation. Most previous reports of isoniazid-induced pancreatitis have been clinically mild forms, and the patient fully recovered with supportive management. However, this case presents severe and permanent pancreatic damage that developed with 5 weeks of isoniazid treatment. When a patient presents with manifestations of pancreatitis during treatment of tuberculosis that includes isoniazid, the physician should consider isoniazid-induced pancreatitis.
Humans ; Isoniazid ; Pancreatitis ; Recurrence ; Tuberculosis ; Tuberculosis, Pulmonary ; Withholding Treatment

A 69-year-old female patient presented with a huge liver mass at another hospital. Computed tomography (CT) revealed a huge, well-demarcated, low-attenuated mass in the right lobe of the liver and multiple nodules in both lungs. The liver mass invaded the colon at the hepatic flexure and infiltrated into the retroperitoneum. Spiral CT revealed a huge tumor thrombus in the right ventricle (RV). The enhancement pattern of the right ventricular mass was identical to that of the liver mass. After ultrasonography-guided needle biopsy of the liver mass, the patient was diagnosed with intrahepatic sarcomatoid cholangiocarcinoma. Although we recommended debulking open-heart surgery for the prevention of sudden death caused by massive pulmonary embolism, the patient and her family opted against surgery due to high operation-related mortality and old age. The patient later died of massive pulmonary embolism at another hospital a few weeks later.
Aged ; Biopsy, Needle ; Cholangiocarcinoma ; Colon ; Death, Sudden ; Female ; Heart Ventricles ; Humans ; Liver ; Lung ; Pulmonary Embolism ; Thrombosis ; Tomography, Spiral Computed

An emphysematous pancreatitis is a rare, but fatal subtype of acute pancreatitis. Gas-forming bacteria from the bowel may penetrate the pancreas to cause emphysematous pancreatitis. It is characterized by the presence of gas within pancreas bed or retroperitoneal cavity at computed tomographic image and carries a high mortality rate. It requires fluid resuscitation and anti-bacterial therapy to control infection, and needs to consider percutaneous drainage or surgical management depending on the clinical condition. We report a case of 73-year-old patient presented with an emphysematous pancreatitis which developed fulminant multi-organ failure in spite of intensive medical treatment along with a review of the related literatures.
Aged ; Bacteria ; Drainage ; Humans ; Mortality ; Multiple Organ Failure ; Pancreas ; Pancreatitis* ; Pancreatitis, Acute Necrotizing ; Resuscitation ; Retroperitoneal Space

We retrospectively reviewed the cases in which complications occurred during below-the-knee (BTK) endovascular treatmentsthat were performed at our hospital from 2005 to 2014. Several interesting cases have been described herein. All the patientshad diabetes and non-healing wounds on their feet and/or rest pain in their foot or leg, and therefore, endovascular treatmentwas performed for the BTK arteries of the affected lower extremity. The complications that occurred during the procedure wereclassified into six categories—vascular spasm, flow limiting dissection, perforation, broken guidewire, distal thromboembolism,and unusual puncture site bleeding. Each complication has its own solutions and management. We discuss these different classesof complications and describe how cases of each type were managed.