1.Left Ventricular Cardiac Output in Term Newborn Infants: Changes Associated with Closure of Ductus Arteriosus.
Ho Jin OH ; You In PARK ; Chang Sung SON ; Young Chang TOKGO ; Pyung Hwa CHOE
Journal of the Korean Pediatric Society 1989;32(8):1045-1050
No abstract available.
Cardiac Output*
;
Ductus Arteriosus*
;
Humans
;
Infant, Newborn*
2.Change of Cerebral Blood Flow Velocity in Normal Newborn Infants.
Sang Hee KIM ; Se Jin KANG ; Chang Sung SON ; Pyung Hwa CHOE ; Nam Joon LEE
Journal of the Korean Pediatric Society 1989;32(8):1037-1044
No abstract available.
Blood Flow Velocity*
;
Humans
;
Infant, Newborn*
3.Diagnosis and Clinical Courses of 108 Foreign Body Aspiration Cases.
Jin Ah SON ; Su Hwa PARK ; Han Shin JEONG ; Kang Mo AHN ; Sang Il LEE
Pediatric Allergy and Respiratory Disease 2007;17(2):117-126
PURPOSE: Foreign body aspiration in the tracheobronchial tree is a common medical emergency in children and represents an important cause of morbidity and mortality. This study was aimed to analyze the clinical spectrum of tracheobronchial foreign bodies in children and to evaluate the causes of late diagnoses. METHODS: A total of 108 patients with foreign body aspiration were recruited in the last 10 years, who had a flexible or rigid bronchoscopic examination. The age, sex, symptoms, causes of aspiration, radiologic findings, and clinical courses were investigated retrospectively. Patients were divided into 2 groups according to the elapsed time from aspiration to a definite diagnosis as early (< or =24 hours after aspiration) and late diagnoses (>24 hours after aspiration). The two groups were compared for clinical courses, radiologic findings, and the duration of admission of early- and late-diagnosed foreign body aspiration. RESULTS: Approximately 80% of the patients were less than 24 months of age and the most common symptoms were the sudden onset of a cough. Hyperinflation or obstructive emphysema (52.8%) and normal chest radiographs (19.4%) were the most frequent radiologic findings. Plain chest radiographies revealed visible foreign bodies in 7.4% of all patients with foreign body aspiration. Nuts were the most common foreign bodies aspirated. Sudden onset of a persistent cough and fever were predominant in the late-diagnosed group.(P<0.05) CONCLUSION: Our results suggest that clinical suspicion upon interviewing is enough to indicate bronchoscopy. The best way to reduce the number of accidents and deaths associated with foreign body aspiration is to promote public prevention polices.
Bronchoscopy
;
Child
;
Cough
;
Delayed Diagnosis
;
Diagnosis*
;
Emergencies
;
Emphysema
;
Fever
;
Foreign Bodies*
;
Humans
;
Mortality
;
Nuts
;
Radiography, Thoracic
;
Retrospective Studies
;
Thorax
4.Quadruple Thera py of Behcet's Disease.
Hyuck Woo SON ; Ju Hwa LEE ; Myung Jin JOO
Journal of the Korean Ophthalmological Society 2000;41(10):2220-2225
Behcet's disease is a multisystematic inflammatory disorder affecting eyes. Visual loss is the most serious effect of Behcet's disease with posterior segment involvement.Because of the disorder's devastating visual consequences, its treatment has received considerable attention.Since the treatment of Behcet's disease has often been unsatisfactory, many different types of treatment have been attempted. We retrospectively reviewed the charts of 28 patients with severe ocular Behcet's disease involving posterior segment.The patients with posterior segment involvement were initially treated with triple regimen (corticosteroid, colchicines, and azathioprine).If intraocular inflammation does not resolve or the inflammatory process recurs, combination with low doses of cyclosporine should be considered (quadruple therapy).Over the course of therapy, visual acuity improved in 25 of 51 eyes (49.01%), remained stable in 14 of 51 eyes (27.45%), and declined in 12 of 51 eyes (23.52%).It improved or maintained the visual acuity in 39 of 51 eyes.There were no serious side effects attributable to triple or quadruple therapy that required withdrawal. The use of corticosteroids, colchicines, azathioprine, and cyclosporine may improve therapeutic efficacy and limit the adverse drug effects, and this combination method appears to be an effective treatment for the ocular complications of Behcet's disease.
Adrenal Cortex Hormones
;
Azathioprine
;
Cyclosporine
;
Humans
;
Inflammation
;
Retrospective Studies
;
Visual Acuity
5.Cardiovascular Effects of Isoflurane in Korean Dogs .
Seok Hwa YOON ; Soo Chang SON ; Jung Eun LEE ; Se Jin CHOI
Korean Journal of Anesthesiology 1991;24(3):635-641
7 Korean dogs were anesthetized with oxygen and isoflurane in different concentrations (1 vo1.%, 2 vo1.%, 3 vo1.%). Cardiovascular effects of isoflurane in different concentrations were investigated. The results were as follow: 1) Heart rate was decreased significantly (p<0.05) following increase of isoflurane concentrations. 2) Mean arterial blood pressure was decreased significantly (p<0.05) following increase of isoflur- ane concentrations. 3) Cardiac index was decreased significantly (p<0.05) following increase of isoflurane concentra- tions. 4) Left ventricular stroke work index was decreased significantly (p<0.05) following increase of isoflurane concentrations. 5) Pumonary artery pressure and pumonary artery wedge pressure were decreased significantly (p<0.05) following increase of isoflurane, but there were no significant changes in central venous pressure, systemic vascular resistance and pulmonary vascular resistance.
Animals
;
Arterial Pressure
;
Arteries
;
Central Venous Pressure
;
Dogs*
;
Heart Rate
;
Isoflurane*
;
Oxygen
;
Pulmonary Wedge Pressure
;
Stroke
;
Vascular Resistance
6.Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in Seoul, Korea
Jiwoo SIM ; Euncheol SON ; Minsu KWON ; Eun Jin HWANG ; Young Hwa LEE ; Young June CHOE
Infection and Chemotherapy 2024;56(2):204-212
Background:
The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission during the endemic phase may vary from that during the previous pandemic phase. We evaluated the risk of infection in a general population with laboratory-confirmed coronavirus disease 2019 (COVID-19) in a community setting in Korea.
Materials and Methods:
This study included 1,286 individuals who had been in contact with an index COVID-19 case between January 24, 2020, and June 30, 2022. Variables such as age, sex, nationality, place of contact, level of contact, the status of exposed cases, period, and level of mask-wearing were assessed.
Results:
Among 1,286 participants, 132 (10.30%) were confirmed to have COVID-19. With increasing age, the risk of the exposed persons contracting COVID-19 from index cases tended to increase (P <0.001), especially for people in their 70s (odds ratio, 1.24; 95% confidence interval, 1.11–1.40; P <0.001). We found an increasing trend in the risk of a COVID-19 exposed case becoming a secondary infection case (P <0.001) in long-term care facilities where the attack rate was high.
Conclusion
The risk of COVID-19 transmission is high in long-term care facilities where many older adults reside. Intensive management of facilities at risk of infection and strict mask-wearing of confirmed COVID-19 cases are necessary to prevent the risk of COVID-19 infection.
7.A Case of Satoyoshi Syndrome Presented with Progressive Muscular Spasm and Alopecia.
Kyung Ran SON ; Jin Hwa KOOK ; Byung Ju KIM ; Sung Jin KIM ; Jae Sook MA
Journal of the Korean Pediatric Society 2002;45(9):1165-1169
Satoyoshi syndrome(generalized Komuragaeri disease) is a rare disorder of unknown cause, characterized by progressive, painful, intermittent muscle spasms and alopecia. Endocrinopathy with amenorrhea, secondary skeletal abnormalities, and diarrhea or unusual malabsorption are frequently seen. It seems that autoimmunity may play a role in its pathogenesis. We report a 13-year-old girl with characteristic manifestations of the syndrome. She was treated with intravenous gammaglobulin and Prednisolone. Painful muscle cramps were gradually improved, but the scalp condition did not change. Satoyoshi syndrome should be considered in children with unexplained muscle spasms and alopecia.
Adolescent
;
Alopecia*
;
Amenorrhea
;
Autoimmunity
;
Child
;
Diarrhea
;
Female
;
Humans
;
Muscle Cramp
;
Prednisolone
;
Scalp
;
Spasm*
8.A Case of Conjoined Twins.
Mi Hwa KANG ; Son Moon SHIN ; Jin Gon JUN ; Mi Jin KIM ; Hae Joo NAM ; Sung Rim KIM ; Jong Wook KIM
Yeungnam University Journal of Medicine 1988;5(2):255-261
Conjoined twinning is a rare congenital malformation, accounting for 1% monozygotic twins. Conjoined twins result if twining is initiated after the embryonic disc and rudimentary amniotic sac have been formed and if division of the embryonic disc is incomplete. Recently we experienced a case of conjoined twins, dicephalus dipus dibrachius, who had died at 3 hours of life, and performed autopsy. Autopsy revealed a total duplication of the heads, spines up to sacrum, small bowels, thymus and lungs. Two hearts existed within a common pericardium.
Autopsy
;
Head
;
Heart
;
Humans
;
Lung
;
Pericardium
;
Sacrum
;
Spine
;
Thymus Gland
;
Twins, Conjoined*
;
Twins, Monozygotic
9.Hyperpigmentation of Both Hands due to Vitamin B12 Deficiency.
Jin Hwa SON ; Hyunju JIN ; Hyangsuk YOU ; Woo haing SHIM ; Gun Wook KIM ; Hoon Soo KIM ; Hyun Chang KO ; Moon Bum KIM ; Byung Soo KIM
Korean Journal of Dermatology 2018;56(7):455-456
No abstract available.
Hand*
;
Hyperpigmentation*
;
Vitamin B 12 Deficiency*
;
Vitamin B 12*
;
Vitamins*
10.PCR and RFLP-based CYP2D6(B) and CYP2D6(T) Genotyping for Korean Lung Cancer Cases and Controls.
Jin Ho CHUN ; Chang Hee LEE ; Sang Hwa URM ; Byung Chul SON ; Jun Han PARK ; Kui Oak JUNG ; Chang Hak SOHN ; Hye Kyoung YOON ; Choon Hee SON ; Hyung In KIM ; Jin Seok KIM
Korean Journal of Preventive Medicine 1998;31(1):1-14
The genetically determined CYP2D6 activity is considered to be associated with cancer susceptibility with inter-individual variation. Genetic polymorphism of CYP2D6(B) and CYP2D6(T) was determined by the two polymerase chain reaction(PCR) and BstN1 and EcoN1 restriction fragment length polymorphisms(RFLP) for 67 lung cancer cases and 95 healthy volunteer controls. The cases were composed of 26 squamous cell carcinoma, 14 small cell carcinoma, 10 adenocarcinoma, 3 large cell undifferentiated carcinoma, and 14 not histologically diagnosed. The results were gained from the 142 subjects (57 cases and 85 controls) who observed successfully in two PCR and BstN1/EcoN1 RFLP. Only one and no mutant allele of the CYP2D6(B) and CYP2D6(T) gene was detected, that is, the frequency of mutant allele was very low; 0.7%(1/142) and 0%(0/142), respectively. Detected mutant allele of the CYP2D6(B) was heterozygous type(WM). The odds ratios for lung cancer susceptibility with CYP2D6(B) and CYP2D6(T) genotype were not calculated. These results are similar to the previous understanding that the mutant allele is very rare in Orientals compared to Caucasians, therefore, it considered that CYP2D6(B) and CYP2D6(T) genotypes have maybe no association with lung cancer susceptibility in Koreans. This is the basic data of CYP2D6(B) and CYP2D6(T) genotypes for Koreans. It would be hepful for further study to determine lung cancer susceptibility of Koreans with the data about CYP1A1, CYP2E1, GSTM1 from future study.
Adenocarcinoma
;
Alleles
;
Carcinoma
;
Carcinoma, Small Cell
;
Carcinoma, Squamous Cell
;
Cytochrome P-450 CYP1A1
;
Cytochrome P-450 CYP2D6
;
Cytochrome P-450 CYP2E1
;
Genotype
;
Healthy Volunteers
;
Lung Neoplasms*
;
Lung*
;
Odds Ratio
;
Polymerase Chain Reaction*
;
Polymorphism, Genetic
;
Polymorphism, Restriction Fragment Length