No abstract available.
Fractures, Malunited* ; Radius*

The purpose of this study was to develop an osteogenic, biodegradable material using polymer and BMP. It was designed to have structural function and be moldable, for the reconstruction of load bearing areas and deformities of various configurations. Bone apatite was added to Poly(L-lactide)(PLLA) and made porous for osteoconductability and ease of BMP loading. The materials, with or without BMP purified from porcine bone matrix, were evaluated in cranial bone defect models in rats for biocompatibility and bone regeneration capability. The following results were obtained: The PLLA-BMP material with BMP added to the polymer showed 30% healing of cranial bone defects in rats during the 2 weeks to 3 months period of observation. The moldable PLLA agent without BMP also showed 25% bone healing capacity. Although new bone formation was incomplete in the critical size defect of rat cranium, it can be concluded that the unique moldability of those agents makes them useful for the reconstruction of various bone defects and maxillofacial deformities.
Animals ; Bone Matrix ; Bone Morphogenetic Proteins* ; Bone Regeneration ; Congenital Abnormalities ; Osteogenesis ; Polymers* ; Rats ; Skull ; Weight-Bearing

We examined several kinds of immunocompromied patients for onyr,homycosis. The incidence of onychomycosis in the patients with connective tissue disease treated with corticosteroid was significantly higher than the incidences in the patients with solid tumors trcated with chemotherapeutic agents, in the patients with leukernia (WBC<1, 000/cm3), and in the control patients. Although conventional corticosteroid trcatment do not disseminate the superficial fungal infection, it may perpetuate the low grade dermatophytosis.
Connective Tissue Diseases* ; Connective Tissue* ; Humans ; Immunocompromised Host ; Incidence ; Onychomycosis* ; Tinea

No abstract available.
Bilophila*

No abstract available.
Bilophila*

No abstract available.
Congenital Hypothyroidism*

No abstract available.
Action Potentials* ; Adult* ; Humans ; Median Nerve* ; Ulnar Nerve*

The thoracolumbar spine is relatively easily traumatized and result in serious complications such as neurologic impairment and instability, so its proper management is very important. Formerly the thoracolumbar spine injury was evaluated mainly by plain radiographs, and tomograms if indicated,but because computed tomography visualizes bone and soft tissues three-dimensionally, we tried to compare its value with that of plain radiographs in potentially unstable thoracolumbar injuries. From January 1984, we determined the stability of the potentially unstable thoracolumbar spine injury according to computed tomography finding and compared with plain radiography finding, and the following results were obtained. 1. By Holdsworth classification, it was difficult to determine the stability of the thoracolumbar spine injury. 2. In cases of compression fracture and burst fracture by Denis classification, it was necessary to determine the stability by computed tomography. 3. In cases of unstable burst fracture by McAfee classification, there was no direct relationship between the degree of canal occlusion and neurological deficit, but above 25% in conus medullaris lesion and above 50% in cauda equina lesion usually manifested neurological deficit. 4. In our cases, the neurological status of initial injury was important factor to determine the improvement rate.
Cauda Equina ; Classification ; Clinical Study ; Fractures, Compression ; Radiography ; Spinal Cord ; Spine

No abstract available.
Kidney*

After bone damage of the fetal rat femurs induced by administrating cyclophosphamide(CP),(1/8 LD50) to the pregnant rat on 13th day of gestation, the effects of serum and ascorbic acid on the repair process of the bone during organ culture were studied, histologically and scanning electron microscopically. CP-damaged fetal femurs harvested at 20 days of gestation were cultured fro 2, 5 and 7 days in the waymouth media(WM) with or without fetal bovine serum(FBS) and ascorbic acid, and were observed with light microscope and JSM-35C scanning electron microscope. The results were as follows:1. CP-damaged bone tissue cultured in WM with 10% FBS showed relatively enhanced activities in the differentiation of chondrocytes and ossificstion as compared to that cultured in WM. 2. CP-damaged bone tissue cultured in WM with 10% FBS and 100µg/ml ascorbic acid, showed increase in the length of the bone marrow cavity, and active formation of new osteoid and collagen bundles. 3. The bone tissues cultured in WM with 10% FBS and 400µg/ml ascorbic acid revealed active deposition of bone matrix, thickening of periosteum and marked elongation of the bone marrow cavity. 4. Bone trabeculae of CP-damaged femurs cultured for 2 days in WM showed poor cell proliferation and insignificant bone matix formation. 5. The number of new cells and the amount of the collagen fibrils increased on the bone trabeculae of the bone cultured in WM with 10% FBS as compared to that cultured in WM and this increase was enhanced as the culture time progressed. 6. A remarkable increase was noted in the number of cells and collagen fibrils in the bone tissues cultured in WM with 10% FBS and ascorbic acid than in those cultured in WM with 10% FBS. 7. The number of the spherules formed by cellular component with collagen fibrils is more numerous than that formed by calcospherites associated with collagen fibrils.
Animals ; Ascorbic Acid ; Bone and Bones ; Bone Marrow ; Bone Matrix ; Cell Proliferation ; Chondrocytes ; Collagen ; Cyclophosphamide ; Femur ; In Vitro Techniques ; Organ Culture Techniques ; Periosteum ; Pregnancy ; Rats