This study was done on 171 volunteers in order to investigate the present status of cutaneous normal flora of Candida species and the distribution of Candida species on the normal human skin in dermatologic clinic of Korea University Hospital from January, ]984 to December, 1984. Among the 171 volunteers, 115 strains of Candida species were identified by culture on the Sabouraud's dextrose agar media, germ tube test, sugar assimilation test, sugar fermentaion test and culture on corn meal with Tween 80 media, The results were summarized as follows: 1. The incidence of cutaneous normal flora of Candida species was 13, 5,5 (115 species among 855 sites) 2. Candida species were distributed in oral cavity(45 species), 4th interdigital toe web(39 species), groin(12 species), axilla(11 species) and 4th interdigital finger web(8 species) in order of frequency. 3, Of ll5 species, 45 species were cultured in summer, 27 species in autumn, 18 species in winter and 14 species in spring. 4 Of 115 Candida species, C. albicans(88 species), C. parapsilosis(12 species), C, tropicalis(8 species), C. guilliermondii(3 species) and C. stellatoidea(2 species) were identified. Two species could not be identified.
Agar ; Candida* ; Fingers ; Glucose ; Humans* ; Incidence ; Korea ; Meals ; Polysorbates ; Skin* ; Toes ; Volunteers ; Zea mays

Congenital ectodermal dysplasia are a group of familial disorders that affect tissues and organs of ectodermal origin to varying degrees. It devided hidrotic type and anhidrotic type by geneologic origin and distinct clinical manifestationa. The hidrotic type usually trait by autosomal dominant gene and manifested dystrofic nails, defect of hair and eyebrow and palmoplantar hyperkeratosis. This patient is 16 year oId male. He had been dystrophic nails, alopecia since at birth, thereafter palmoplantar hyperkeratosis, clubbing fingers noted. C.R.C. Urinalysis, stool examination, chest x-ray were within normal limit. Biopsy specimen from palm revealed hyperkeratosis, hypergranulosis, acanthosis and, mild inflamrnatory cell infiltrate on upper dermis. Biopsy speeimen from the scalp revealed norrriaI findings except slight hypoplasia of ebaceaus gland.
Alopecia ; Biopsy ; Dermis ; Ectoderm ; Ectodermal Dysplasia* ; Eyebrows ; Fingers ; Genes, Dominant ; Hair ; Humans ; Male ; Parturition ; Scalp ; Thorax ; Urinalysis

Intraosseous ganglion is a benign cystic lesion. It is composed of fibrous tissue with mucoid changes located in the subchondral bone adjacent to a joint. Intraosseous ganglion has been reported in various skeletal sites and most commonly in the lower end of the tibia and femur. However reports of intraosseous ganglion of the glenoid are rare, with only 14 cases in the literature. We repot 2 cases of intraosseous ganglion of the glenoid with literature reviews.
Bone Cysts ; Femur ; Joints ; Tibia

A study of concentration smear, culture for AFB and sensitivity test for antituberculous drugs was carried out in 810 patients who had been admitted in SNUH in the period of 12 months from January 1976 to December 1976. Acid-fast bacilli was confirmed in 110 cases (13.6%) by concentrated direct smear and in 88 cases(10.9%) by culture, and concomitantly sensitivity test was performed in 26 isolated cases. Streptomycin, INH, PAS, Kanamycin and Ethionamide were rather less sensitive to the strains of Mycobacterium tuberculosis, but all strains obtained during the period of this study were highly sensitive to Rifampicin.
Ethionamide ; Humans ; Kanamycin ; Mycobacterium tuberculosis ; Mycobacterium ; Rifampin ; Streptomycin

A clinical observation of cutaneous complications was made on 200 patients receiving cancer chemotherapy at the Department of Internal Medicine, Seoul National University from January through May, 1986. The results were as follows: 1. Among the 200 patients, 191 case(95. 5%) showed cutaneous complications 2. The cutaneous complications included the following; hyperpigmentation(14l cases, 70. 5%), alopecia(138 cases, 69.4%), nail change(118 cases, 59.0%), mucositis(47 cases, 23.5%), dryness of the skin(40 cases, 20.0%), seborrheic dermatitis(24 cases, 12. 2%), increase of seborrheic keratosis(11 cases, 5.6%), folliculitis or acneiform eruptions(9 cases, 4,5%), melasma(6 cases, 3.0%), gynecomastia(3 cases, 1.5%), vessel hardening or dimpling(3 cases, 1.5%), radiation recall(2 cases, 1.0%), hyperhydrosis(2 cases), photosensitivity(1 case, 0.5%), tissue necrosis(1 case), facial flushing(1 case), purpura(1 case) and obesity(1 case), 3 Steps were taken to determine the chemotherapeutic agents causing these cutaneous complications, though in some cases it was difficult in determining exaetlr which chemotherapeutic agent was the cause of the observed cutaneous complication.
Drug Therapy* ; Folliculitis ; Humans ; Internal Medicine ; Seoul

A clinical observation of the nail pigmentation change was made on 200 patients receiving cancer chemotheray who were seen at; the Department of Internal Medicine, Seoul National University Hospital, from January through May, 1986. The results were as follows: l. Among the 200 patients, 118 cases(59%,) showed nail pigmentation changes. 2. The patterns of nail pigmentation change were as follows: Parallel transverse band(70 cases 59.3%), longitudinal pigmentated band(32 cases, 27. 1%), brown arc(25 cases, 21. 2%), Proximal black pigmentation(10 cases, 8. 5%), diffuse pigmentation(5 cases, 4.2%), parallel transverse white line(5 cases, 4.2%), half and half nail(3 cases, 2. 5%), pigmentations with transverse white band(1 case, 0. 8%). 3. Various cambinations of nail pigmentation pattern were found in 33 patients (28. 0%). 4. 11 cases of the nail dystrophy with nail pigmentation change were observed: Longitudinal ridge(7 cases), transverse groove(3 cases), wavy transverse fissure (1 case).
Drug Therapy* ; Humans ; Internal Medicine ; Pigmentation ; Seoul

No abstract available.
Stevens-Johnson Syndrome*

We report a case of morphea profunda in a 21-year-old male who had diffuse brown sclerotic plaques on his extremities. Laboratory findings showed peripheral eosinophilia and an increased titers for anti-DNA and anti-nuclear antibodies. Histopathologic findings showed diffuse fibrosis and a thickening of the lower dermis and subcutaneous tissue. He has been treated with hydroxychloroquine 400mg per day and the sclerosis of the skin improved.
Antibodies ; Dermis ; Eosinophilia ; Extremities ; Fibrosis ; Humans ; Hydroxychloroquine ; Male ; Scleroderma, Localized* ; Sclerosis ; Skin ; Subcutaneous Tissue ; Young Adult

A case of cutaneous sarcoidosis in the 66 year-old Korean female patient is presented. She shows typical skin manifestations of plaque type in the absence of other common objective evidence of systemic involvement. Diagnosis was confirmed by charcteristic histological findings and positive Kveim test with the support of other compatible clinical and biochemical findings. She had been followed up for 3 years since the first visiting. Recently chest X-ray, slit lamp examination and skin biopsies were taken again, but failed to reveal any significant interval changes.
Aged ; Biopsy ; Diagnosis ; Female ; Humans ; Kveim Test ; Sarcoidosis* ; Skin ; Skin Manifestations ; Thorax

Adenoma of the nipple is a benign tumor of the lactiferous ducts of the nipple which frequently causes erosion of the surface. It can clinically mmic Paget's disease and histologically be misdiagnosed as a well-differentiated adenocarcinoma. A 20-year-old woman developed an erythematous oozing patch on the right nipple two years ago, which subsequently developed iiito verrucous surfaccd papules. A biopsy specimen of the lesion showed focal acanthosis of the epidermis. The tumor was composed of fairly well-circumscribed, glandlike structures within the nipple stroma. Ductlike struciures, papillary areas, solid nests of cells and cysts lined by squarnous epithelium, could be seen, Two cell types lining the ducts were recognized; inner columnar cells and peripherally located cuboidal cells. Although simple excision of the adenoma is the treatment of choice, our case was treated successfully by electrucoagulation.
Adenocarcinoma ; Adenoma* ; Biopsy ; Epidermis ; Epithelium ; Female ; Humans ; Nipples* ; Young Adult