1.A Study of Nucleolar Organizer Regions in Normal and Neoplastic Epithelial Cells of Stomach.
Hee Jin CHANG ; Kyung Ha KANG ; Jung Hee PARK ; Jin Hee SOHN ; Jung Il SUH
Korean Journal of Pathology 1992;26(5):451-458
Nucleolar organizer regions are DNA loops encoding rihbosomal RNA production and detectable by the argyrophilia of their associated proteins(AgNORs). AgNOR numbers correlate with cellular proliferating activity. Many studies have shown a significnt difference in AgNOR counts between benign and malignant tumors. AgNOR counts were also helpful in differential diagnosis. For the evaluation of its diagnostic utility in gastric lesions, a silver staining technique was carried out in paraffin sections of 5 control cases, 5 benign peptic ulcers, 7 hyperplastic polyps, 10 tubular adenomas, 16 early gastric adenocarcinomas and 15 advanced gastric adenocarcinomas. The results were as follows. The mean numbers of AgNORs in early and advanced gastric adenocarcinomas(1.94 and 2.16) were significantly higher than those of normal foveolar epithelium(1.43) and epithelia of benign gastric ulcers(1.54), hyperplastic polyps(1.64) and tubular adenomas(1.79). In malignancy, there was increased variability in size and shape of AgNORs. There was little differences in mean AgNOR numbers between early and advanced gastric adenocarcinomas. Differentiation of the tumor made no difference in AgNOR numbers. From the above results, the AgNORs count, if its morphologic change are taken into consideration, is helpful in differentiation between malignant and non-malignant lesions.
Diagnosis, Differential
;
Adenocarcinoma
2.Pathologic Analysis of Gallbladder Cancer by the Stage and Intestinal Metaplasia with the Diagnostic Significance of CEA and p53.
Korean Journal of Pathology 1997;31(7):599-607
Twenty cases of gallbladder cancers were examined using 5 mm stepwise tissue sections. We analyzed the clinicopathologic findings of the early (stage 1, II) and advanced carcinoma (stage III, IV, V) and those of carcinoma with or without metaplasia in the tumor. We also performed CEA and p53 immunohistochemical staining and compared their findings with those of normal mucosa and preneoplastic lesions. The results were as follow: 1) All of the early carcinomas (n=5) were incidentally diagnosed after the resection for the gallstone. They were compared to advanced carcinoma (n=15) in the absence of the lymphatic or angioinvasion, recurrence, metastasis and death. 2) Metaplastic and non-metaplastic carcinoma did not reveal any difference of the clinicopathologic findings except age distribution. 3) CEA and p53 were positive in preneoplastic and malignant lesions. The extent of staining was related to the degree of the atypia. From the above results, an early detection of gallbladder cancer is very important for the prognosis of the patients. Since preoperative diagnosis is difficult, thorough pathologic examination of routinely resected gallbladder is necessary for the early diagnosis. CEA and p53 immunohistochemical staining may be helpful in the differential diagnosis of non-neoplastic and neoplastic lesion of the gallbladder.
Age Distribution
;
Diagnosis
;
Diagnosis, Differential
;
Early Diagnosis
;
Gallbladder Neoplasms*
;
Gallbladder*
;
Gallstones
;
Humans
;
Metaplasia*
;
Mucous Membrane
;
Neoplasm Metastasis
;
Prognosis
;
Recurrence
3.Hyperplasia, Metaplasia, and Dysplasia of the Gallbladder Correlation to Gallbladder Adenocarcinoma.
Korean Journal of Pathology 1997;31(6):527-537
The correlation of metaplasia to dysplasia and carcinoma in the gallbladder has attracted the attention of many investigators. We mapped and examined a total of 263 cholecystectomized gallbladders to analyze the mucosal changes in the carcinogenesis of the gallbladder. Stones were present in 59.7%, hyperplasia in 28.5%, metaplasia in 55.5% (gastric 37.6%, intestinal 17.9%), dysplasia in 17.1% (low grade 9.1%, high grade 8%) and carcinoma in 7.6%. Metaplasia was more frequently identified in the stone-positive group (62.4%) than in the stone-negative group (45.3%) (P<0.05). Especially, the incidence of intestinal metaplasia was significantly higher in the stone-positive group. Dysplasia and carcinoma were more frequent in the metaplasia-positive group (dysplasia 26.7%, carcinoma 11%) than in the metaplasia-negative group (dysplasia 5.1%, carcinoma 3.4%) (P<0.05). Their incidences were significantly higher in the intestinal metaplasia than in the gastric metaplasia. Forty four percent of the dysplasia-positive cases were associated with carcinoma in the adjacent mucosa but carcinoma was absent in the dysplasia-negative cases. Hyperplasia did not reveal any significant correlation with metaplasia, dysplasia and carcinoma. These results suggest that gallstone is causally related to the metaplasia in the gallbladder and the metaplasia-dysplasia- carcinoma sequence exists in the gallbladder.
Adenocarcinoma*
;
Carcinogenesis
;
Gallbladder*
;
Gallstones
;
Humans
;
Hyperplasia*
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Incidence
;
Metaplasia*
;
Mucous Membrane
;
Research Personnel
4.Non-psychiatric nurses' opinions about psychiatric consultation.
Journal of Korean Neuropsychiatric Association 1991;30(3):540-551
No abstract available.
5.Angiofollicular Lymph Node Hyperplasia(Castleman's disease): 3 cases report.
Jeong Hee PARK ; Gil Ro HAN ; Hee Jin CHANG ; Jin Hee SOHN ; Jung Il SUH
Korean Journal of Pathology 1992;26(3):298-305
Angiofollicular lymph node hyperplasia(AFLNH) was first described in 1956 by Castleman et al. It was initially reported as a solitary mediastinal mass but multicentric and extranodal disease is now well known. Histologically two distinct variants, e.g. the hyaline vascular type and the plasma cell type, of AFLNH are recognized. And the plasma cell type is typically associated with clinical syndrome consisting of fever, anemia, elevated erythrocyte sedimentation rate and polyclonal hypergammaglobulinemia. Recently, we experineced three cases of AFLNH. Histologically, two cases were hyaline vascular type, that were presented as a right supraclavicular mass of 49-year-old female, and as an anterior mediastinal mass of 53-year-old female. The remaining one case was plasma cell type that was presented as a left axillary mass of 63-year-old male. The former two cases showed typical features of hyaline vascular type but in case 1, exuberant proliferation of hyalinized vessels of capillary size was characteristic feature. The latter case of plasma cell type characteristically showed clinical syndrome consisting of fever, hypoalbuminemia, polyclonal hypergammaglobulinemia. All cases were presented as a single mass and they were well after surgical excision.
Female
;
Humans
6.Cytologic feature of papillary carcinoma of the thyroid.
Jeong Hee PARK ; Hee Jin CHANG ; Kyung Ha KANG ; Jin Hee SOHN ; Jung Il SUH
Korean Journal of Cytopathology 1991;2(2):111-118
No abstract available.
Carcinoma, Papillary*
;
Thyroid Gland*
7.Nutrition Care of Diet - refusal Patients having Difficulties in Adapting to Hospital Diet.
Hye Jin KIM ; Su Jin JUN ; Kyung Hee JUNG
Journal of the Korean Dietetic Association 2001;7(1):65-71
The purpose of this study was to produce proper nutrition and foodservice through positive intervention for diet-refusal patients who has difficulties in adaptation to hospital diet, and to contribute to hospital management with the focus of fast recovery. The survey was conducted using questionnaires between July 18 and August 17, 2000. The subjects were consisted of 24 diet-refusal patients who were hospitalized in St. Mary's Hospital except the patients hospitalized for the purpose of operation or pre-therapy tests. Also chart reviews were conducted. The statistical analysis of data was done by SAS/win 6.11 package to determine descriptive analysis and paired t-test and Pearson's correlation. The summary of study results is as follows : 1. Most of the subjects was receiving chemotherapy. The leading place for offering private food was from patient's home. Subjects worried about delayed recovery from illness due to nutritional problems caused by extreme fasting. The problems were in order of anorexia, nausea and vomiting during therapy process. 52.4% of subjects ate hospital diet after positive intervention. 2. Major reasons of hospital diet-refusal patients' dissatisfation were in order of expeness, dissatisfation, serum total protein levels were significantly lower(p<.05). 3. Serum Alb(p<.05), Hb(p<.05), Hct(p<.05) and TLC(p<.001) levels showed significantly negative correlations with fasting duration. With these results, it is concluded that a major cause of malnutrition among patients is to last fasting.
Anorexia
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Diet*
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Disulfiram*
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Drug Therapy
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Fasting
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Humans
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Malnutrition
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Nausea
;
Surveys and Questionnaires
;
Vomiting
8.A Case of Hereditary Anhidrotic Ectodermal Dysplasia.
Jong Won LEE ; Jin Kyung JUNG ; Jin Gun BANG ; Jin Sam RHO ; Jung Hee PARK
Journal of the Korean Pediatric Society 1994;37(10):1453-1456
Hereditary anhidrotic ectodermal dysplasia is a rare condition characterized by underdeveloped ectodermal structure including the skin, teeth or skin appendages. The patient has characteristic feature of anhidrosis, hypotrichosis and defective dentition. We experienced a case of hereditary anhidrotic ectodermal dysplasia in a l-month-old male infant who had unexplained recurring fever, anhidrosis and characteristic facial feature, so we established the diagnosis with clinical feature and skin biopsy.
Biopsy
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Dentition
;
Diagnosis
;
Ectoderm
;
Ectodermal Dysplasia*
;
Fever
;
Humans
;
Hypohidrosis
;
Hypotrichosis
;
Infant
;
Male
;
Skin
;
Tooth
9.A clinical study on patients presenting with upper gastrointestinal symptoms.
Sang Yoo CHANG ; Sang Won JUNG ; Jin Hee CHANG ; Jung Jin CHO
Journal of the Korean Academy of Family Medicine 1993;14(2):88-94
No abstract available.
Humans
10.Immunocytochemical Expression of Amylin in Pancreatic Islets of Man, Rabbit and Guinea Pig.
Sung Gyung KIM ; Young Hee KIM ; Jung Ho CHA ; Jin KIM ; Jin Woong JUNG
Korean Journal of Anatomy 1997;30(4):411-420
A putative polypeptide hormone identified as amylin[islet amyloid polypeptide] is synthesized and co-localized with insulin in B cells of pancreatic islets in several animal species including man. However, there is growing evidence that somatostatin cells are also expressed and contained amylin in the pancreatic islets of the rat The aim of the present study was to investigate the immunocytochemical expression of the amylin within the endocrine pancreas of the man, rabbit and guinea pig, with special reference to the possible ability of islet cells other than insulin cells to synthesize amylin. For this purpose serial sections of the pancreatic islets were stainedimmunocytochemically using anti-amylin, anti-insulin, anti-glucagon, anti-somatostatin antisera. In serial sections of pancreatic islets of the man and rabbit, it was shown that amylin immunoreactivity occurred in insulin-reactive B cells predominantly located in interior of the islets. In contrast, amylin immunoreacivity appeared in glucagon-reactive A cells peripherally located in the islets of the guinea pig. These results suggest that in both the man and rabbit, amylin is synthesized by B cells for subsequent co-secretion with insulin, and that in guinea pig, amylin is synthesized by A cells for co-secretion with glucagon. It thus appears that amylin release may be mediated by different secretory mechanisms according to animal species.
Amyloid
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Animals
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B-Lymphocytes
;
Glucagon
;
Guinea Pigs*
;
Guinea*
;
Immune Sera
;
Immunohistochemistry
;
Insulin
;
Islet Amyloid Polypeptide*
;
Islets of Langerhans*
;
Rats
;
Somatostatin-Secreting Cells