To assess the effectiveness of Magnetic Resonance Imaging (MRI) with endorectal surface coil in the ataging of carcinoma of the uterine cervix with emphasis on parametrial involvement. Thirty women with clinically and radiographically proven carcinoma of the uterine cervix were initially included for this study, but thirteen patients were excluded since the stages of tumors wore beyond stage IIa. CT and MR findings of the remaining seventeen patients were performed at Cheil General Hospital and compared a1ong with clinical findings with the special emphasis on the parametrial involvement by the tumor. Staging was assessed by CT and MRI, and the results were compared with the pathologic staging. Radiea1 abdominal hysterectomy with the pelvic and paraaortic lymphnode dissection was done to all sewenteen patients. The staging made primarily by CT and MRI was either stsge 1 or Ila, but MR images with endorectal surface coil was superior to CT in the visualization of depth of tumor infiltration, especially parametrial involvement. The determination of the depth of the tumor made by MR images showed statistically significant correlation with histologic evaluation(R =0.768, p<0.01). The accuracy rate for the evaluation of the parametrial invo1vement was 82.3% far CT and 94.1% for MRI with endorectal surface coil. The overall accuracy rate for tumor staging was 70.5% for clinical, 58.8% for CT and 82.3% for MR evaluation. The accurecy rate in evaluation of the pelvic and paraaortic lymphnode was 88.2% for CT, but the evaluation done by MRl was not adequate due to small FOV(field of view). In assessment of The steging of careinoma of the uterine cervlx, MR images with endorectal surface coil was superior to CT, especially in the evaluation of the parametrial involvement.
Cervix Uteri* ; Female ; Hospitals, General ; Humans ; Hysterectomy ; Magnetic Resonance Imaging* ; Neoplasm Staging

No abstract available.
Abdominal Pain* ; Peptic Ulcer*

OBJECTIVE: It has been suggested that the occurrence of persistent pain signal during the early postnatal period may alter an individual's response to pain later in life. The aim of this study is to assess whether neonatal nerve injury resulted in long-lasting consequences on nociceptive system in the rat. METHODS: We examined whether neuropathic pain behaviors and the changes of spinal neuropeptides (SP, CGRP, VIP and VIP) induced by peripheral nerve injury within 1 day after birth (Neonate group) were different from those at 8 weeks after birth (Mature group). RESULTS: The Neonate group showed more robust and long-lasting pain behaviors than the Mature group. Immunohistochemical findings demonstrated that spinal SP- & CGRP-immunoreactivities(ir) of the ipsilateral to the contralateral side increased in the Neonate group, whereas those decreased in the Mature group. In addition, increase in spinal VIP- & NPY-ir of the ipsilateral to the contralateral side was more robust in the Mature group than in the Neonate group. CONCLUSION: These results suggest that peripheral nerve injury in the early postnatal period may result in long-lasting and potentially detrimental alterations in nociceptive pathways.
Animals ; Humans ; Hyperalgesia ; Infant, Newborn ; Neuralgia* ; Neuropeptides* ; Parturition ; Peripheral Nerve Injuries* ; Peripheral Nerves* ; Rats*

The cilio-retinal artery appears on the temporal side of the optic disc margin and is concerned with the supply of the portion between the optic disc and the macula. So, the cilio-retinal artery preserves vision when occlusion of the central retinal artery occurs. The aberrant macular artery is very rare and in most of the cases have been derived from the inferior temporal arterial or venous trunks. When this artery is appeared, the corrected vision is normal but sometimes diminished. The authors have experienced two aberrant retinal vessels of a large cilio-retinal artery and aberrant macular artery combined with the Stargardt's maculopathies. It was reviewed clinically with the literature.
Arteries ; Retinal Artery ; Retinal Vessels* ; Retinaldehyde*

Spontaneous renal ruptures are clinically unusual, and usually occur secondary to various kinds of underlying disease, such as a benign or malignant tumor, vascular disease and infection, etc. A renal cell carcinoma is the most common cause, and those caused by a transitional cell carcinoma are extremely rare. Herein is reported our experience of a case of a spontaneous rupture, with a renal pelvis transitional cell carcinoma, in a 48-year-old man.
Carcinoma, Renal Cell ; Carcinoma, Transitional Cell* ; Humans ; Kidney ; Kidney Pelvis* ; Middle Aged ; Rupture* ; Rupture, Spontaneous ; Vascular Diseases

To evaluate the expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in thyroid neoplasms in a Korean population, we studied a total of 154 cases: papillary carcinoma of classical type (PTC), 86; follicular adenoma (FA), 21; follicular carcinoma (FC), 35; medullary carcinoma (MC), 3; undifferentiated carcinoma (UC), 5; and Hurthle cell neoplasm (HN), 4. Using immunohistochemical staining, COX-2 expression was detected in 62 (72.1%) PTC specimens, 5 (23.8%) FA specimens, 10 (28.6%) FC specimens, 0 (0.0%) MC specimens, 1 (20.0%) UC specimen, and 3 (75%) HN specimens. iNOS expression was detected in 66 (76.7%) PTC specimens, 4 (19.0%) FA specimens, 13 (37.1%) FC specimens, 0 (0.0%) MC specimens, 3 (60.0%) UC specimens, and 4 (100%) HN specimens. The results showed that COX-2 and iNOS were frequently expressed in the PTC and HN specimens, and iNOS was more frequently overexpressed in the FC specimens than in the FA specimens. In PTC, COX-2 and iNOS were significantly overexpressed in patients over 45 yr of age (p=0.029, p=0.041), and iNOS expression was increased in patients with a large primary tumor (p=0.028). These results suggest that the upregulation of COX-2 and iNOS may contribute to the tumor progression of thyroid gland, particularly in PTC and HN, and iNOS may play an adjuvant role during the tumor progression of FC.
Tumor Markers, Biological/*analysis ; Tissue Distribution ; Thyroid Neoplasms/*diagnosis/*enzymology ; Statistics ; Sensitivity and Specificity ; Reproducibility of Results ; Nitric Oxide Synthase Type II/*analysis ; Neoplasm Proteins/*analysis ; Middle Aged ; Male ; Humans ; Gene Expression Profiling ; Female ; Cyclooxygenase 2/*analysis ; Aged ; Adult

Serum levels of T3, T4, TSH, 24-h RAIU and Thyroid antibodies were examined in 13 cases of chronic lymphocytic thyroiditis who were diagnosed at the pediatric department of Yonsei University hospital during the period from 1978 to 1980. The results were as follows: 1. The age distribution was dispersed between 8 and 15 years of age and all the cases were female. 2. Common symptoms were Goiter, Poor Weight gain, fatigness, cold intolerance, lethargy, constipation and cold sweating. But in 5 cases(38%), there were no subjective symptoms. 3. The patients were classifed by their thyroid function state, as 1 case of hyperthroid group, 10 cases of euthyroid group, and 2 cases of hypothyroid group. 4. In the Euthyroid patients, Serum T3 concentration was 115-230ng/100ml)mean 167.4ng/100ml), T4 concentration 4.8-18.6microgram/100ml(mean 7.3 microgram/100ml) T3/T4 ratio 0.020-0.028(mean 0.024) and TSH was 37-60microU/ml(mean 49.5microU/ml). In the hyperthyroid patient, serum T3 concentration was 310ng/100ml. T4 concentration 14.9microgram/100ml, T3/T4 ratio 0.020 and TSH was 1.35microU/ml. 5. In 24-h RAIU, Euthyroid patients were in 2 cases of decreased state(15%), 2 cases of normal range (15~45%), and 6 cases of increased state(45%). All Hypothyroid patients were in normal range and hyperthyroid patient was in increased state. 6. Thyroglobulin antibody was positive in all the patients except 2 cases and microsomal antibody was positive in all the cases. 7.1 year of follow up study was performed in 4 cases of euthyroid patients, 1 case of hyperthroid patient, and 2 cases of hypothroid patients. There was no euthyroid patient who became hypothyroid state in the follow up study.
Age Distribution ; Antibodies ; Constipation ; Female ; Follow-Up Studies ; Goiter ; Hashimoto Disease ; Humans ; Lethargy ; Reference Values ; Sweat ; Sweating ; Thyroglobulin ; Thyroid Gland* ; Thyroiditis* ; Weight Gain

The eye tumors are divided into intraocular and extraocular, and mainly involve lids, conjunctiva, cornea, and orbit. The authors analysed histopathological and clinical review of 9 cases of eye tumors that had experienced.
Conjunctiva ; Cornea ; Orbit

No abstract available.
Trisomy*

BACKGROUND: Identifying the donor and isolation-related factors during the islet isolation would be greatly helpful to improve the result of human islet isolation for successful clinical islet transplantation. METHODS: Sixty-nine pancreata from cadaveric donors were isolated with standard protocol and analyzed to identify the donor factors and isolation variables for successful isolation. Islet isolations recovered > or = 100,000 Islet Equivalent (IEQ, n=53) were compared to islet mass less than 100,000 IEQ (n=16). RESULTS: The mean islet recovery was 216.0 x 10(3) +/- 173.7 x 10(3) (IEQ) before purification and 130.6 x 10(3) +/- 140.2 x 10(3) (IEQ) after purification. Mean purity was 54 +/- 31%. Mean age of donor was 31.2 +/- 13.2 year and mean cold ischemic time was 6.9 +/- 6.2 hour. Quality of isolated islets was acceptable in terms of bacterial culture, viability and secretory function in vitro and in vivo. In univariate analysis on successful isolation, status of pancreas was the only significant factor and sex, duration of collagenase expansion and digestion time were marginal factors. Stepwise multivariate logistic regression analysis showed donor sex, status of pancreas and digestion time were significant factors for the successful islet isolation. CONCLUSION: This study confirms some donor factors and variables in isolation process can influence the ability to obtain the successful isolation of human islet. Enough experiences and pertinent review of donor and isolation factors can make islet isolation successful, supporting the clinical islet transplantation without spending of cost.
Cadaver ; Cold Ischemia ; Collagenases ; Digestion ; Humans* ; Islets of Langerhans Transplantation ; Logistic Models ; Pancreas* ; Tissue Donors