The author reviewed the toxicity and complications of tumor radiotherapy and chemotherapy from the aspects of etiology,pathogenesis and differential treatment of TCM

Chemotherapy plays an important role in advanced colorectal cancer. Patients may show various clinical response to selection different drugs. The importance of individual therapy based on pharmacogenomics has been emphasized in cancer therapy. To explore the individual therapy of colorectal cancer,the progress of molecular markers which influence the efficacy of anti-tumor drugs containing fluorouracil,oxaliplatin,CPT-11,monoclonal antibody drugs is reviewed in this article.

Objective To explore the clinical efficacy of combination therapy with promethrin and gliclazide sustained-release tablets in the treatment of obese patients with type 2 diabetes mellitus with poor blood glucose control. Methods Selected from December 2015 to March 2017 in our hospital treated 96 cases of insulin treatment of poor blood glucose control in obese patients with type 2 diabetes, were randomly divided into study group and control group, 48 cases in each group.The study group were treated with Novolin 70/30(Novolin 30R)combined with Gliclazide Sustained-release Tablets,while the patients in control group were treated with Novolin 30R combined with repaglinide. Results The decrease of FBG, 2h PG, HbAlc, HOMA-IR and the increase of HOMA-IS in the study group were better than those in the control group (P<0.05).There was no significant difference in BMI between the two groups after treatment and BMI in the control group was significantly higher than that before treatment (P<0.05),CRP was not statistically significant before treatment.Conclusion The application of Novolin 30R and Gliclazide Sustained-release Tablets after treatment can make the use of insulin alone poor glycemic control in obese patients with type 2 diabetes have more desirable clinical efficacy,is conducive to ensuring the safety and effectiveness of drugs.

Autophagy is an important pathway in the body to remove damaged cell organelles and dysfunctional proteins to maintain protein equilibrium and intracellular homeostasis by the lysosomal system .As a degenerative disease of central nervous system , the main feature of Alzheimer ’ s disease is abnormal protein aggregation .However , the role of autophagy in the pathogenesis of Alzheimer ’ s disease is not fully clear yet .The aim of this paper is to take β-amyloid peptide as a starting point to explore the relationship between autophagy and β-amyloid peptide in the pathogenesis of Alzheimer’s disease.

Objective To detect the expression of Id1 and p53 in human breast cancer and study their relationship. Methods To choose 80 cases of breast cancer from the surgical department of Tangshan people's hospital. All patients didn't get radiotherapy and chemotherapy before surgery. The expression of Idl and p53 of breast cancer were studied by using SABC immunohistochemistry. Results The expressions of Id1 were found in cytoplasm, while the expression of p53 was found in cell nucleus. The positive rates of Id1 and p53 were 87.5 %(70/80)and 90.0%(72/80) respectively in breast cancer tissues. The expression of Id1 and p53 were significantly higher in breast cancer tissue than those in adjacent non-tumor breast tissues,benign tumor tissues and normal breast tissues(P ＜0.05). The positive rates and expression intensity of Id1 in breast cancer had significant correlation with lymph node metastasis and pTNM stage of the tumor, but had no significant correlation with age, histological differentiation and tumor size. The positive rates and expression intensity of p53 in breast cancer had significant correlation with lymph node metastasis of the tumor, but had no significant correlation with age, histological differentiation,tumor size and pTNM stage. Conclusion Expression of Id1 in human breast cancer is up-regulated. Its expression is associated with lymph node metastasis and TNM stage and represents an independent marker for prognosis of breast cancer. To reduce the expression of Id1 will become the strategy of curing breast cancer. Expression of Id1 and p53 in human breast cancer have the same clinic significance. Each of them can represent an independent marker for prognosis of breast cancer.

Objective:To detect the changes on the ratio of T lymphocyte subgroup and immunoglobulin(Ig) in peripheral blood of patients with Primary extranodal lymphoma(PENL).Methods:The peripheral blood T lymphocyte subgroup ratio and immunoglobulin(Ig) complement C3,C4 content were detected by Flow Cytometry(FCM) and Immunoturbidimetry.Results:The numbers of CD3,CD4 or CD8 was lower(P

Objective To sum up the clinical experience in the diagnosis and treatment of recurrent retroperitoneal malignant fibrous histiocytoma (RMFH). Methods[WT5”BZ] Clinical data of 29 recurrent RMFH from 1990 to 2002 were retrospectively analyzed. ResultsTwelve (41.4%) cases underwent total tumor resection after the first recurrence. Seven cases underwent multiple viscera resection,of which two did after the first recurrence,three after second and the other two after third recurrence. Twenty-five patients were followed up for 6 months to 8 years,The 1,3 and 5 year survival rate was 73.2%,46.7% and 19.8% respectively. [WT5”HZ]ConclusionTotal tumor resection is an effective way to treat RMFH,and multiple viscera combined resection increases the success rate of total tumor resection.

Chemotherapy plays an important role in advanced colorectal cancer. Patients may show various clinical response to selection different drugs. The importance of individual therapy based on pharmacogenomics has been emphasized in cancer therapy. To explore the individual therapy of colorectal cancer, the progress of molecular markers which influence the efficacy of anti-tumor drugs containing fluorouracil, oxaliplatin, CPT-11, monoclonal antibody drugs is reviewed in this article.

OBJECTIVE:To compare the effects and costs between metformin and acarbose when combined with insulin in treating type2diabetes mellitus.METHODS:Cost-minimization analysis in medical economy was applied to analyze the therapeutic effects,costs and cost related factors with the respect for the patients.RESULTS:There was no statistically sig?nificant difference in effects of the2therapeutic regimens.Total cost and drug cost per head in metformin group were1941.46yuan and138.86yuan respectively as compared with2308.37yuan and229.82yuan respectively in acarbose group.The analysis on cost related factors showed no statistical significance.CONCLUSION:Metformin combined with insulin is a preferable therapeutic regimen.

Forty-four guinea-pigs were sensitized by intramuscular inoculation with the same amount (0.8ml) of 5% egg albumin in water. 3 weeks after sensitization, the animals were rondomly divided into 1 groups (group J as control; group II given small dose of piperitone 0.08ml/ 100g body weight; group J given large dose of piperitone 0.12ml/100g body weight; group IX given promethazine 2.5mg 100g body weight) and subjected to anaphylactic insult by intra-cardiac injection of 1ml of 5% egg albumin in water under the protection of different dosege of piperitone, a terpene from cymbopogon distans. given intramuscularly. Results of the experiment indicates that piperitone had significant dose-effect relation protective effect against the anaphylactic insult on the guinea-pigs and suggests that piperitone might be used clinically for the treatment of asthma