Congenital lingual cyst is rare and there has been no prior case report about prenatally detected lingual cyst in Korea. When a huge oral cyst is observed at prenatal period and can cause life-threatening airway obstruction at birth, ex utero intrapartum treatment (EXIT) procedure is needed to secure the airway. Herein we present a baby with a prenatally detected huge oral cyst. He was delivered safely assisting EXIT procedure and underwent an operation for resection of the cyst from his tongue. The oral cyst was diagnosed as a lingual cyst with rare histologic type consisting mixed gastrointestinal and respiratory epithelium.
Airway Obstruction ; Korea ; Mouth ; Parturition ; Respiratory Mucosa ; Tongue

Hamartoma of the bladder is quite a rare entity which is composed of a disorderly admixture of mature cellular elements normally present in the urinary bladder. There is a great controversy regarding the pathogenesis of this lesion. Whether it is a true hamartomatous lesion or metaplastic lesion developed secondary to the inflammatory process. Similar or identical lesions has often been given by other names such as florid examples of cystitis glandularis. We prefer to cell florid examples of cystitis glandularis rather than hamartoma when it was occurred in an old age higher then 50th decade. Here we report a case of hamartoma of the urinary bladder in 44 years old man. Cystoscopic examination revealed a papillary polypoid mass which was attached to the fundus of bladder by long stalk. The mass measured 1.5 cm in greatest diameter. It was composed of epithelial nests resembling von Brunn's nest, cystitis glandularis or cystitis cystica dispersed in a stroma rich in smooth muscle and fibrous tissue.
Hamartoma

BACKGROUND : DHEAS, the major circulating adrenal hormone, has been suggested to have a role in many aging related diseases and perhaps in aging itself. But, there is no epidemiologic data of DHEAS in normal adults in Korea. We studied age changes and sex differences in serum DHEAS & its related factors throughout adulthood. METHODS : We administ structured questionnaires to the study subjects. We measured serum DHEAS levels and several biochemical markers (total cholesterol, triglyceride, HDL-cholesterol, glucose etc) in 1.710 healthy men(857) and women (853), aged 17-76 years. We also measured their height, weight, waist & hip circumference and body fat contents with bioimpedance method. We analyzed various variables relating to serum DHEAS levels by using SPSS. Reference data of serum DHEAS level in normal adults were also suggested. RESULTS : The DHEAS concentration peaked at age group blow age of 30 years in man(260.9 microgram/dL). Then mean values declined steadily in both sexes (r=-0.38, p<0.001 in men and r=-0.46, p<0.001 in women). At age group above 70 years, only 30.9% in men & 30.4% in women, when compared with age group below 30 years, was remained. DHEAS concentration were significantly higher in men than women at all age group except age group above 70 years. Average 1.5 times higher concentration in men than in women (at least 1.28 times at age<30 and max 2.00 times at age 60-64). In men, DHEAS had higher mean value in smokers (218.1 vs 199.1 microgram/dL, p<0.05), drinkers (>or=2 times/week, 219.1 vs 185.3 microgram/dL, p<0.01), android type fat distribution group (waist/hip>0.85, 227.1 vs 197.4 microgram/dL) after adjusting age. DHEAS was positively correlated with body mass index (r=0.12, p<0.01). But in women, drinkers (154.3 vs 131.7 microgram/dL, p<0.05) and regular exercise group (146.1 vs 131.6 microgram/dL, p=0.05) had higher mean DHEAS value. There were no significant association between DHEAS and lipid profile (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol) & fasting glucose level in both sex. CONCLUSION : Our data suggest that DHEAS levels may influenced by several sociodemographic factors (e.g. smoking, alcohol, exercise etc) and body mass index. DHEAS level was inversely correlated by age in both sex and men had 1.5 times higher DHEAS values than women. We could not find any association between DHEAS level and lipid profile & fasting blood sugar.
Adipose Tissue ; Adult ; Aging ; Biomarkers ; Blood Glucose ; Body Mass Index ; Cholesterol ; Dehydroepiandrosterone Sulfate* ; Dehydroepiandrosterone* ; Fasting ; Female ; Glucose ; Hip ; Humans ; Korea ; Male ; Surveys and Questionnaires ; Sex Characteristics* ; Smoke ; Smoking ; Triglycerides ; Waist-Hip Ratio

No abstract available.

The fetus papyraceus is a remarkably mumified fetus and the complication is rare in multiple pregnancy. If one fetus of multiple pregnancy died in uterus remote from term and other fetus did not, the fetus with placenta is compressed by the membrane of living fetus in uterus and then the dead fetus becomes a fetus papyraceus. Recently we had experienced two cases of fetus papyraceus in twin pregnancy at our department of Obstetrics and Gynecology, Keimyung University School of Medicine. We present these cases with brief literatures.
Female ; Fetus* ; Gynecology ; Humans ; Membranes ; Obstetrics ; Placenta ; Pregnancy ; Pregnancy, Multiple ; Pregnancy, Twin* ; Uterus

Background: The prevalence of sleep disorders increases as pregnancy progresses, which affects the health of pregnant women, fetal health, and the outcomes of pregnancy. The aim of this study is to evaluate the quality of sleep and life in pregnant women in Korea. Methods: This study is a prospective cross-sectional, case-control study of pregnant women and age-matched controls. From July to September 2019, all participants completed Korean-language versions of the sleep questionnaires including Pittsburgh sleep quality index (K-PSQI), Insomnia severity index, Epworth sleepiness scale, Back’s depression inventory-2(K-BDI), STOP (Snoring, Tiredness, Observed apneas, and high blood Pressure), and short-form 36 (K-SF-36). Results: A total of 422 participants consisted of 385 pregnant women and 137 controls. Second and third trimester were 200 and 185, respectively. K-PSQI scores were higher in pregnant women compared with the controls (7.87±3.49 and 8.50±3.55 vs. 5.79±2.76, p<0.001). Total score of K-SF-36 was lowest in third trimester (62.07±17.72) and highest in the control group(79.41±13.36). There was no statistical difference between groups in K-BDI. Conclusions This study demonstrated worsening of sleep quality as well as life quality during pregnancy. More attention to sleep of pregnant women is needed.

Mosaic trisomy 14 syndrome is a well-known but unusual chromosomal abnormality with a distinct and recognizable phenotype. Array comparative genomic hybridization (CGH) analysis has recently become a widely used method for detecting DNA copy number changes, in place of traditional karyotype analysis. However, the array CGH shows a limitation for detecting the low-level mosaicism. Here, we report the detailed clinical and cytogenetic findings of patient with low-frequency mosaic trisomy 14, initially considered normal based on usual cut-off levels of array CGH, but confirmed by G-banding karyotyping. Our patient had global developmental delay, short stature, congenital heart disease, craniofacial dysmorphic features, and dark skin patches over her whole body. Estimated mosaicism proportion was 23.3% by G-banding karyotyping and 18.0% by array CGH.
Chromosome Aberrations ; Chromosomes, Human, Pair 14 ; Comparative Genomic Hybridization ; Cytogenetics ; DNA Copy Number Variations ; Heart Diseases ; Humans ; Hypogonadism ; Intellectual Disability ; Karyotype ; Karyotyping ; Mitochondrial Diseases ; Mosaicism ; Ophthalmoplegia ; Phenotype ; Skin ; Trisomy

We obtained successful functional and esthetic results by grafting of iliac marrow-cancellous bone in 2 cases of alveolar-palatal cleft patients. Bone graft of alveolar-palatal clefts provide bony support to adjacent teeth of cleft area, prevented from relapse of orthodontic arch expansion, closure of oroantral fistula and improvement of speech problem. 1. In one case, extraction of upper right central incisor that was little bone support, alignment of rotated teeth and expansion of collapsed arch segment were done with pre-orthodontic treatment. The other case. Bone grafting was done after removal of prosthesis with no pre-orthodontic treatment. 2. After mucoperiosteal incision in cleft area, the mucosal flap of labial area, palate and nose were separation and the raised nasal mucosa was sutured for closure of oroantral fistula. Then, the iliac marrow-cancellous bones were grafted to cleft site. 3. After 6 months of operation, we had seen the new bone deposition to cleft site in dental radiograph and prosthetic treatment of missing teeth were done.
Bone Transplantation* ; Humans ; Incisor ; Nasal Mucosa ; Nose ; Oroantral Fistula ; Palate ; Prostheses and Implants ; Recurrence ; Tooth ; Transplants

OBJECTIVES: In this study, we compared anxiety, depression, and maternal-fetal attachment between high-risk pregnant women and normal pregnant women, and investigated whether there was a correlation between anxiety, depression, and maternal-fetal attachment in each group.METHODS: Two hundred and eleven pregnant women(118 high-risk pregnant women, 93 normal pregnant women) were recruited. All subjects were administered a sociodemographic and obstetric questionnaire, Stait Trait Anxiety Inventory-State(STAI-S), Beck Depression Inventory- II(BDI-II), and Maternal-Fetal Attachment Scale(MFAS).RESULTS: Total score of STAI-S in high-risk pregnant women was 13.704 point higher than that in normal pregnant women(95% CI=10.449–16.959, p<0.001). Also, total BDI-II score in high-risk pregnant women was 5.325 higher than that in normal pregnant women(95% CI=1.850–3.711, p<0.001). There was no significant difference between total MFAS score of normal pregnant women and that of high-risk pregnant women(t=1.594, p=0.112). There was a significant positive correlation between anxiety and depression in both normal(r=0.529, p<0.001) and high-risk(r=0.582, p<0.001) groups. In normal pregnant women, there was a significant negative correlation between anxiety and maternal-fetal attachment(r=−0.284, p=0.006).CONCLUSION: High-risk pregnant women experienced more anxiety and depression than normal pregnant women, and the maternal-fetal attachment was not significantly different between the two groups. The higher the level of anxiety of the pregnant women, the lower the degree of maternal-fetal attachment. Psychological support for dealing with the emotional problems of high-risk pregnant women and promoting maternal-fetal attachment is needed.
Anxiety ; Depression ; Female ; Humans ; Pregnancy, High-Risk ; Pregnant Women

Background: In accordance with the guidelines for the expectant management of women exposed to previable preterm premature rupture of membrane, we compared neonatal outcomes according to the latent period from membrane rupture to delivery among extremely preterm infants exposed to maternal preterm premature rupture of membrane using the Korean Neonatal Network database. Methods: Of the 3,305 extremely preterm infants born at 23–27 weeks' gestation between 2014 and 2017 who were registered in the Korean Neonatal Network, 1,464 infants were born to pregnant women who were exposed to preterm premature rupture of membrane. The short latency group was defined as infants born with a latent period between membrane rupture and delivery < 7 days (n = 450), whereas the prolonged latency group was defined as infants born with a latent period of ≥ 7 days (n = 434). Using well-established risk factors for adverse short-term outcomes, multivariate logistic regression analysis was performed to assess a prolonged latent period in preterm premature rupture of membrane as an independent risk factor for neonatal outcomes in extremely preterm infants exposed to preterm premature rupture of membrane. Results: The mean gestational age at membrane rupture in the prolonged latency group was significantly lower than that in the short latency group (22.7 ± 2.5 vs. 25.4 ± 1.3 weeks, P < 0.001). Nevertheless, the mean gestational age at delivery and birth weight were not significantly different between the two groups. The incidence of oligohydramnios and histologic chorioamnionitis in the prolonged latency group was significantly higher than that in the short latency group (38.7 [155/401] vs. 26.1 [105/403], 69.8 [270/384] vs. 61.0 [242/397], respectively, P < 0.05). The survival rate in the prolonged latency group did not differ from that in the short latency group (71.2 [309/434] vs. 73.3 [330/450], P = 0.478). Although the prolonged latency group was not associated with mortality during hospitalization in the multivariate logistic regression analysis, the prolonged latency group's early pulmonary hypertension and bronchopulmonary dysplasia rates were increased by 1.8 and 1.5 times, respectively. Conclusion A prolonged latent period of 7 days or more does not affect the survival rate but increases the risk of bronchopulmonary dysplasia occurrence among extremely preterm infants who are exposed to maternal preterm premature rupture of membrane.