1.Cross-lagged analysis of acute stress disorder, posttraumatic stress disorder and depressive symptoms among children after Lushan earthquake
Lin FU ; Jin CHENG ; Zhengkui LIU
Chinese Mental Health Journal 2017;31(7):548-553
Objective:To examine the relationships between acute stress disorder (ASD) symptoms,posttraumatic stress disorder (PTSD) symptoms and depressive symptoms in children survivors following the Lushan earthquake in China.Methods:One hundred ninety-seven children aged 1 to 14years (93 male and 104 female) were followed up at two and six weeks after Lushan earthquake.The ASDS,UCLA PTSD Reaction Index and DASS were used to measure the ASD,PTSD and depressive symptoms.Results:The average scores of ASDS and the depression subscale of DASS at two weeks after earthquake were(36.5 ± 10.9) and (3.3 ± 2.8),respectively.The average scores of UCLA PTSD Reaction Index and the depression subscale of DASS-21 at six weeks after earthquake were (18.5 ± 12.6) and (3.3 ± 3.5),respectively.The rates of ASD and PTSD were 28.6% and 8.2%,respectively.The cross-lagged structural equation analysis with latent variables indicated that the ASD symptoms at two weeks after earthquake positively predicted PTSD symptoms (β =0.59,p < 0.001) and depressive symptoms (β =0.29,p <0.001) at six weeks after earthquake.But there was no significant association between depressive symptoms at two weeks and PTSD symptoms at six weeks after earthquake.Conclusion:ASD symptoms in the early time postearthquake could predict subsequent PTSD and depressive symptoms,while depressive symptoms tend to remain stable within six weeks after earthquake.
2.Review of evaluation and influencing factors of oral drug absorption fraction
Ping ZHANG ; Fu-lin BI ; Jin YANG
Acta Pharmaceutica Sinica 2024;59(1):84-93
Fraction absorbed (Fa) is an important parameter to describe the absorption level of oral drugs, and an important basis for the development and optimization of the formulation process. Because it is easily confused with the concept of absolute bioavailability, it has not received enough attention from the industry. There are many complex factors affecting Fa. There are three time-related factors that directly affect the extent of Fa: the release time, the absorption time, and the residence time. The relationship between these three time-related factors determines the extent of Fa. Generally, we are more concerned about the apparent factors that affect the extent of Fa, including independent variables and covariates; The independent variables include administered dose, route, dosage form, etc. The covariates are divided into internal and external factors, and external factors include food factors, drug interactions,
3.Malignant melanoma of the back metastatic to thyroid gland: report of a case.
Cheng-lin FU ; Xian-tu ZHANG ; Jin-na ZHANG
Chinese Journal of Pathology 2011;40(2):121-122
Aged
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Back
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Carcinoma, Medullary
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metabolism
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pathology
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Diagnosis, Differential
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Female
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Humans
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Melanoma
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metabolism
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pathology
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secondary
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surgery
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Melanoma-Specific Antigens
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metabolism
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S100 Proteins
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metabolism
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Skin Neoplasms
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metabolism
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pathology
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surgery
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Thyroid Neoplasms
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metabolism
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pathology
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secondary
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surgery
4.Clinical effects of triamcinolone acetonide combined with laser photocoagulation on patients with retinal vein occlusion
Jin-Ying, ZHANG ; Lin, LIU ; Fu-Bin, WANG ; Jie, CHEN
International Eye Science 2014;(12):2220-2222
AlM: To observe the effects of the coelomic cavity injection of triamcinolone acetonide ( TA) combined with laser photocoagulation on patients with retinal vein occlusion.
METHODS:Fifty-six patients of retinal obstruction with macular edema were accepted from January 2010 to December 2012 in our hospital. All patients received iodized lecithin and Xueshuantong. And, patients with central retinal vein occlusion ( CRVO ) , hemi- central retinal vein occlusion ( hemi-CRVO ) and branch retinal vein occlusion ( BRVO ) treated by TA combined with laser photocoagulation, respectively. Follow-up period was of at least 6mo
RESULTS: After the treatment of 1, 3 and 6mo, the central foveal thickness was reduced significantly ( P<0. 05). After followed up 6-12mo, the total effective rate of CRVO, Hemi-CRVO and BRVO patients was 83% ~95% and all the patients had no significant adverse reactions.
CONCLUSlON:Basing on the traditional treatment, TA combined with laser photocoagulation is more effective in the treatment of retinal vein occlusion and is worthy of clinical usage.
5.Changes of matrix metalloproteinase-3 and urokinase-type plasminogen activator receptor in type 2 diabetes mellitus with macroangiopathy
Lei XU ; Xingguo LU ; Huaihong CHEN ; Haiya FU ; Xiaoli LIN ; Qihui JIN
Chinese Journal of Pathophysiology 1989;0(05):-
AIM: To investigate the function of matrix metalloproteinase-3 (MMP-3) and urokinase-type plasminogen activator receptor (uPAR) to macroangiopathy in type 2 diabetes mellitus. METHODS: The levels of MMP-3 and uPAR in plasma were determined by ELISA sandwich method in 26 healthy controls and 39 patients with type 2 diabetes mellitus including 15 complication-free cases and 24 with macroangiopathy. RESULTS: The plasma level of uPAR but not MMP-3 was higher in patients without macroangiopathy than that in normal controls (P
6.Effects of probiotics agents treatment on the couse of subclincal hepatic encephalopathy
Jiansheng LIU ; Yi TIAN ; Ji FU ; Xiaohong ZHANG ; Jin LIU ; Jian LIN
Chinese Journal of Postgraduates of Medicine 2006;0(03):-
0.05).However,significant difference in NCT and DST performance,incidence of HE the 4th week after(P
7.Cloning and expression of Sj423 gene encoding the egg-shell precursor protein of Schistosoma japonicum
Yamei JIN ; Guofeng CHENG ; Jinming LIU ; Zhiqiang FU ; Yaojun SHI ; Jiaojiao LIN ; Youmin CAI
Chinese Journal of Zoonoses 2009;(12):1154-1157
The gene fragment encoding the egg-shell precursor protein of Schistosoma japonicum was amplified with RT-PCR by using PCR primer designed according to the 423 bp cDNA fragment of the Philippine strain of S.japonicum, the corresponding mDNA fragment of Chinese strain as template and then the 5' and 3' ends of this gene cDNA were amplified with 5' RACE and 3' RACE by using a series of primers designed according to the result of sequencing. Result of sequence analysis showed that this fragment, named as Sj423, contained a complete open reading frame (ORF) of gene encoding the egg-shell precursor protein of S.japonicum.(Chinese strain). As demonstrated by sequencing analysis. No intron could be detected in this gene fragment. This gene was subsequently expressed in E.coli after cloning into the expression vector pET28c(+). The molecular mass of the expressed product of this gene was 20.9 kDa as revealed by SDS-PAGE analysis, and Western blot analysis showed that the recombinant protein expressed could react well with the rabbit antiserum against the worm antigen of S.japonicum;indicating the good antigenicity of this expressed product.
9.Studies on preparation by SPG membrane emulsification method and in vitro characterization of tetradrine-tashionone II(A)-PLGA composite microspheres.
Jin LU ; Meng ZHANG ; Hua-xu ZHU ; Li-wei GUO ; Lin-mei PAN ; Ting-ming FU
China Journal of Chinese Materia Medica 2015;40(6):1091-1096
Tetradrine-tashionone II(A)-PLGA composite microspheres were prepared by the SPG membrane emulsification method, and the characterization of tetradrine-tashionone II(A) -PLGA composite microspheres were studied in this experiment. The results of IR, DSC and XRD showed that teradrine and tashionone II(A) in composite microspheres were highly dispersed in the PLGA with amorphous form. The results of tetradrine-tashionone II(A) -PLGA composite microspheres in vitro release experiment showed that the cumulative release amounts of tetradrine and tashionone II(A) were 6.44% and 3.60% in 24 h, and the cumulative release amounts of tetradrine and tashionone II(A) were 89.02% and 21.24% in 17 d. The process of drug in vitro release accorded with the model of Riger-Peppas. Tetradrine-tashionone II(A) -PLGA composite microspheres had slow-release effect, and it could significantly reduce the burst release, prolong the therapeutic time, decrease the dosage of drugs and provide a new idea and method to prepare traditional Chinese medicine compound.
Benzofurans
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chemistry
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Benzylisoquinolines
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chemistry
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Drug Carriers
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chemistry
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Drug Compounding
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instrumentation
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methods
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Drugs, Chinese Herbal
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chemistry
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Kinetics
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Lactic Acid
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chemistry
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Microspheres
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Particle Size
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Polyglycolic Acid
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chemistry
10.Effect of remifentanil on calcium-activated potassium currents in human mesenteric arterial smooth muscle cells
Peng-Tao LIN ; Da-Qing LIAO ; Nan-Fu LUO ; Jin LIU
Chinese Journal of Anesthesiology 1994;0(06):-
Objective To investigate the ionic mechanism of remifentanil-induced vaso-relaxation by recording calcium-activated K~+-currents(IKCa)in human arterial smooth muscle cells(MASMCs).Methods Human MASMCs were obtained freshly by the method of enzymolysis.IKCa were separated with 4-AP 5 mmol?L~(-1) and recorded by the whole-cell voltage-clamped technique.The effects of remifentanil(1.2,4.8,19.4 mmol?L~(-1))on amplitude and threshold of activation for IKCa were assessed.Results Remifentanil significantly increased IKCa and had no effect on the threshold of activation for IKCa as compared with the control group(P<0.05 or 0.01),and the IKCa returned to the baseline level after remifentanil was washed out.Conclusion Remifentanil produces vasodilation by activating IKCa in MASMCs.