1.Stereological study of the effects of Doxycycline on hyperoxic lung injury In neonatal rats
Chinese Pediatric Emergency Medicine 2009;16(3):256-259
Objective To explore the influence and potential protective effects of non-specific panMetrix Metalloproteinases(MMPs) inhibitor Doxycycline on hyperoxic lung injury and lung development in neonatal rats.Methods Neonatal SD rats were divided into 4 groups randomly within 12 hours after birth:air with normal saline(AN),air with doxycycline(AD),hyperoxia with normal saline(ON),and hyperoxia with doxycycline group(OD).Hyperoxia groups(ON and OD) were exposed to ≥90% O2.Doxycycline 20 mg/kg or equal volume of 0.9% saline(Doxycycline concentration 2 mg/ml) was administered by gastric gavage,twice daily from day 1 to experimental day,but it didn't exceed 14 days.Stereological study was carried out at day 1,3,7,14 and 21 after birth.Results Enlarged mean alveolar area was noted both in hyperoxia and Doxycycline groups.OD group had larger star volume than ON group on day 14.Except ON group,all other groups had increased alveolar septum and the condition was worsened by hyperoxia with Doxycycline.The percentage of collagen in lung parenchymal tissue in ON group increased persistently.This increasing trend was stopped in OD group on day 14,and collagen percentage had no significantly difference between OD and AN groups on day 14 and 21.Conclusion Both hyperoxia and Doxycycline influence neonatal lung development,percentage of coUgen in lung parenchymai can be reduced by Doxycycline in hyperoxic lung injury.
2.Dynamic Analysis of Chongqing Health Resource Allocation and Utilization Since Being a Municipality
Chinese Journal of Medical Education Research 2003;0(04):-
This paper gave a dynamic analysis on the health resource allocation and utilization of Chongqing since it became a municipality,found out the extrusive problems existing in the health resource allocation and put forward some corresponding proposals,hoping to benefit the health administration on constituting regional health development planning.
3.Solitary necrotic nodule of the liver.
Zhong ZUO ; Jin-feng ZHANG ; Feng-xian TANG ; Liang FENG
Chinese Journal of Pathology 2006;35(5):317-317
Adenocarcinoma
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complications
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pathology
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surgery
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Aged
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Colectomy
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methods
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Colonic Neoplasms
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complications
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pathology
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Diagnosis, Differential
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Female
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Hepatectomy
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methods
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Humans
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Liver
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pathology
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surgery
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Liver Diseases
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complications
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pathology
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surgery
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Necrosis
4.Detection of mutations of the dystrophin gene in Duchenne muscular dystrophy boys.
Rong HUANG ; Jin-feng ZHANG ; Jun XU
Chinese Journal of Pediatrics 2009;47(1):68-69
Child
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DNA Mutational Analysis
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Dystrophin
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genetics
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Exons
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Humans
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Male
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Muscular Dystrophy, Duchenne
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genetics
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Mutation
5.Extranodal follicular dendritic cell sarcoma of neck region: report of a case.
Chinese Journal of Pathology 2012;41(6):410-411
Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Carcinoma
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metabolism
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pathology
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Cyclophosphamide
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therapeutic use
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Dendritic Cell Sarcoma, Follicular
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drug therapy
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metabolism
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pathology
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surgery
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Diagnosis, Differential
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Doxorubicin
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therapeutic use
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Head and Neck Neoplasms
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drug therapy
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metabolism
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pathology
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surgery
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Humans
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Lung Neoplasms
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drug therapy
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secondary
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Male
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Melanoma
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metabolism
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pathology
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Middle Aged
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Neoplasm Recurrence, Local
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Prednisone
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therapeutic use
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Receptors, Complement 3b
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metabolism
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Receptors, Complement 3d
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metabolism
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Vincristine
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therapeutic use
6.Clinical study of femoral peel-off lesions in acute posterolateral corner injuries
Jin ZHANG ; Hua FENG ; Hui ZHANG ; Lei HONG ; Xuesong WANG
Chinese Journal of Orthopaedics 2011;31(5):456-462
Objective To determine the incidence of clinically common acute avulsions of the popliteus tendon (PT) and the lateral collateral ligament (LCL) of the femur (peel-off lesion) in knees with multiple injured ligaments.Methods A retrospective review of 48 acute grade 3 posterolateral corner (PLC) knee surgeries was conducted.All office evaluations were reviewed to determine the demographic data,tear description,preoperative MRI examination,physical examination under anesthesia,intraoperative arthroscopic findings and surgical techniques.Results In total,19 patients were surgically verified as having femoral peel-off lesions as a portion of a series of multiple pathologic findings.Tear patterns were typically categorized into 3 patterns:isolated PT tear (pattern 1,4 patients),combined PT and LCL tears (pattern 2,8 patients) and complex tears (associated intrasubstance and/or fibular-based injuries,pattern 3,7 patients).Seventeen of the 19 patients underwent preoperative MRI examination,which demonstrated conclusive signs of femoral insertion separation and discontinuity in 13 patients (76%) and inconclusive signs of femoral insertion separation.Examination under anesthesia (EUA) revealed that for the 4 patients with pattern 1 injuries,the tibial external rotation increases were all greater than 10°.For the 15 patients with pattern 2 and 3 injuries,the yarus instability was as follows:grade 3 in 8 patients,grade 2 in 2,grade 1 in 1,and negative in 4.External rotation increases were greater than 10° in 12 patients and less than 10° in 3.Seventeen of the 19 patients were inspected with an arthroscope prior to PLC surgery:of these patients,94% had acute avulsion findings and positive lateral gutter drive-through sign;8 patients were repaired with recess or reattachment procedures;6 patients were primarily reconstructed;4 patients were treated with combined repair and reconstruction;and 1 patient was left untreated for secondary reconstruction due to priority repair for concurrent patellar tendon rupture.Conclusion For adequate clinical identification,we recommend a comprehensive diagnostic protocol,including MRI,physical examination and arthroscopic inspection,to avoid underdiagnosis of the lesion in multiple-ligament injured knees.The lateral gutter arthroscopic evaluation is particularly sensitive for detecting the lesion.
8.Changes of circadian rhythms of FDG uptake in C57BL/6 mice brain and heart.
Jin-ping SHAO ; Hua-feng ZHANG
Chinese Journal of Applied Physiology 2012;28(3):266-274
Animals
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Brain
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metabolism
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physiology
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Circadian Rhythm
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physiology
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Female
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Fluorodeoxyglucose F18
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pharmacokinetics
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Heart
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physiology
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Male
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Mice
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Mice, Inbred C57BL
9.Promethazine should not be used for infants.
Feng-ling XU ; Ya-ming ZHANG ; Ying-ji JIN
Chinese Journal of Pediatrics 2010;48(7):557-557
10.Elastographic characterization of microwave-induced lesions in porcine liver
Jianquan ZHANG ; Zongping DIAO ; Feng LU ; Jianguo SHENG ; Jin HE
Chinese Journal of Ultrasonography 2011;20(1):76-79
Objective To investigate the elasticity reduction of liver tissue due to microwave ablation and the relevance to the histographic damages. Methods An experimental study using fresh porcine liver was designed. Elasto-ultrasonography scanning both in color display and strain ratio calculations was conducted before and 5 min after microwave ablation ( 2450 MHz) in manner of antenna insertion under ultrasound guidance to determine the alterations of the liver elasticity, in correspondence with the histopathologic assessment of each ROI. Results Elasto-ultrasonography showed a significant elasticity reduction and hardness augment of the targeted liver tissue and the corresponding histopathology revealed increases in the amount of massive coagulative necrosis and coking of liver cells after microwave irradiation,in proportional to the applied field power and working time. Conclusions Elasto-ultrasonography helps to demonstrate microwave-induced lesion in porcine liver got rapidly hardened. It is possible to estimate the tissue necrosis to the changing of tissue hardening.