Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization, granulation tissue, and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus, Phellinus gilvus (PG) have various anti-inflammatory activities. In present study, we have assessed the effect of polysaccharides from PG on the dermal wound healing of polysaccharides from PG in streptozotocin-induced diabetic rat model. Six of 6-mm circular wounds were created with biopsy punch on the 4th day after induction of diabetes. After 24 hours, each test substance was applied to the wound twice a day for next 5 days. Circular wounds treated with PG showed significantly reduced wound contraction and complete reepithelialization, as compared to wounds of non-treated (p < 0.05). These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing, and could be developed as a wound healing agent in such clinical settings.
Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents/pharmacology ; Basidiomycota/*metabolism ; Diabetes Mellitus, Experimental/*pathology ; Histocytochemistry ; Male ; Polysaccharides/isolation&purification/*pharmacology ; Rats ; Rats, Sprague-Dawley ; Skin/*injuries ; Streptozocin ; Wound Healing/*drug effects ; Wounds, Penetrating/*drug therapy

No abstract available.
Odontogenic Cyst, Calcifying* ; Odontoma*

No abstract available.
Odontogenic Cyst, Calcifying* ; Odontoma*

BACKGROUNDS: The biliary diseases were one of the most common diseases of intraabdominal diseases, and cholecystectomy was performed first in 1882 by Langenbuch, and since laparoscopic cholecystectomy( L.C) that was new noninvasive method of being avoid the laparotomies was performed first in France, in 1987 by Philippe Mouret, it has become the standard method of treatment for symptomatic cholelithiasis. Laparoscopic cholecystectomy offers the mafority of patients with symptomatic cholelithiasis as an improved treatment option, resulting in significantly less postoperative pain, shorter hospital stays, better cosmetic result, and more rapid return to normal activity than standard open cholecystectomy. METHODS: We compared the 82 patients who underwent laparoscopic cholecystectomy at Chung-nam National University Hospital from Jan. 1993 to Jun. 1998 to the 67 patients undergoing standard open cholectystectomy(O.C) during the same periods. RESULTS: 1) The mean age of L.C group was 53.9 years and that of O.C group was 58.0 years. The male to female ratio of L.C group was 1:1.47 and that of O.C group was 1:1.0. 2) Associated diseases were observed in 31 patients(37.8%) of the L.C group and 36 patients(53.7%) of the O.C group. 3) 6 patients(7.3%) had a previous abdominal operation, with appendectomy, the most frequent among them. 4) The shorter operative time and postoperative hospitalization stay were required to performed laparoscopic cholecystectomy than standad open cholecystectomy(p=0.03, p=0.02). 5) Postoperative compoications were occurred in 6 patients(7.3%) of L.C group. 1 patient was explorated, the remainders were recovered by conservative treatment. 6) On pathologic findings, chronic cholecystitis as seen in 70 pateints(85.4%) were the most frequent in the L.C group. In the O.C group, chronic cholecystitis as seen in 40 pateints(59.7%) were also the most frequent diseases. CONCLUSION: Laparoscopic cholecystectomy has the merits of short operation and admission time, lesser postoperative pain, smaller wound, rapid return to normal life than open cholecystectomy.
Appendectomy ; Cholecystectomy ; Cholecystectomy, Laparoscopic* ; Cholecystitis ; Cholelithiasis ; Female ; France ; Hospitalization ; Humans ; Laparotomy ; Length of Stay ; Male ; Operative Time ; Pain, Postoperative ; Wounds and Injuries

No abstract available.
Pregnancy*

No abstract available.
Animals ; Embryonic Structures* ; Mice*

BACKGROUND: Increased BMD after treatment means that the treatment regimen was effective to prevent fracture associated with osteoporosis. But changes of BMD reflected at least after 1 year. Now we use markers of bone turnover more easily, and they reflects bone metabolism faster than BMD within 3 4 months. Some data showed that changes of bone markers after 3 months could predict the changes of the BMD after 1 year. METHODS: 126 postmenopausal Korean women with osteoporosis were evaluated who visited Samsung Cheil hospital from Aug. 1997 to July 2000, with respect to markers of bone turnover and BMD at lumbar spine. Subjects were classified into 3 groups, HRT only group, HRT with alendronate group and HRT with calcitonin group. To evaluate the effectiveness of treatment regimen, we compared changes of markers after 3 months and changes of spinal BMD after 1 year treatment among 3 groups. And also evaluate the predictability of the changes of markers of bone turnover after 3 months about the changes of spinal BMD, multiple regression analysis were made. RESULTS: Our results showed those findings 1. Percent changes of markers of bone turnover decreased significantly compared with baseline(osteocalcin 30.4 53.4%, total alkaline phosphtase 26.7 20.0%, deoxypyridinoline 19.0 30.1%, and mean percent changes of markers among three groups showed no significant differences. 2. No significant relationships were noted between percent changes of spinal BMD and percent changes of markers of bone turnover. 3. Percent changes of BMD at lumbar spine were increased significantly after 1 year treatment(HRT only 5.6 3.6%, HRT with calcitonin 7.8 4.5%, HRT with alendronate 9.8% 4.7%). CONCLUSION: These results made conclusion that changes of markers of bone trunover after 3 months couldn't predict the changes of spinal BMD after 1 year treatment. But, HRT with antiresorptive agents may be effective in treating postmenopausal osteoporotic Korean women.
Alendronate ; Bone Density Conservation Agents ; Calcitonin ; Female ; Humans ; Metabolism ; Osteoporosis* ; Postmenopause ; Spine

No abstract available.
Cerebellopontine Angle*

Cardiovascular disease (CVD) remains the leading cause of morbidity, mortality, and health care costs in South Korea. The prevalence of preventable and treatable risk factors for CVD such as obesity, hypercholesterolemia, and smoking has continued to increase, despite improvements management of hypertension. Active leadership, participation, and support of professional organizations and medical institutions in national cardiovascular registries and regional treatment network have proven to be effective models to reduce the global burden of CVD in the Europe and North America. Regional treatment network systems for ST-segment elevation myocardial infarction have established to coordinate percutaneous coronary intervention (PCI) treatment centers, non-PCI treatment centers, and emergency centers especially across the Europe. The Act on the Prevention and Management of Cardio-cerebrovascular Disease was enacted in South Korea in 2017 to establish the legal frameworks and a comprehensive plan for the prevention and management CVD and risk factors. To fully achieve the goal of a NationalHealth Plan for Cardiovascular Disease, it is necessary to embark on a nationwide registry project and to promote the regional acute treatment accessibility which can therefore play a key role in achieving the objectives of the 2017 Act. In this regard, the Korean Society of Cardiology advocates a national project for health promotion and cardiovascular prevention to improve cardiovascular outcomes, which includes the expansion and establishment of regional cardiocerebrovascular centers (CCVCs) and new local CCVCs.

Cardiovascular disease (CVD) remains the leading cause of morbidity, mortality, and health care costs in South Korea. The prevalence of preventable and treatable risk factors for CVD such as obesity, hypercholesterolemia, and smoking has continued to increase, despite improvements management of hypertension. Active leadership, participation, and support of professional organizations and medical institutions in national cardiovascular registries and regional treatment network have proven to be effective models to reduce the global burden of CVD in the Europe and North America. Regional treatment network systems for ST-segment elevation myocardial infarction have established to coordinate percutaneous coronary intervention (PCI) treatment centers, non-PCI treatment centers, and emergency centers especially across the Europe. The Act on the Prevention and Management of Cardio-cerebrovascular Disease was enacted in South Korea in 2017 to establish the legal frameworks and a comprehensive plan for the prevention and management CVD and risk factors. To fully achieve the goal of a NationalHealth Plan for Cardiovascular Disease, it is necessary to embark on a nationwide registry project and to promote the regional acute treatment accessibility which can therefore play a key role in achieving the objectives of the 2017 Act. In this regard, the Korean Society of Cardiology advocates a national project for health promotion and cardiovascular prevention to improve cardiovascular outcomes, which includes the expansion and establishment of regional cardiocerebrovascular centers (CCVCs) and new local CCVCs.