Objective To explore the relationship between heart rate variability(HRV)and serum high sensitivity C-reactive protein(hs-CRP)in type 2 diabetic aged patients.Methods Totally 30 aged patients with type 2 DM were enrolled in this study who were selected from the outpatients and inpatients of Department of Gerontology in the Third People's Hospital of Chongqing,and another 30 non-diabetic matched individuals were recruited as control.Their serum hs-CRP and 24 hour-electrocardiography were examined.HRV was assessed by calculating the indices based on statistical operation on RR intervals(time domain analysis)from 24-hour Holter recording,including:standard deviation of normal to normal RR intervals(SDNN),standard deviation of 5-minute mean RR intervals(SDANN)and square root of differences between adjacent NN intervals(rMSSD).Linear correlation analysis was carried out between their serum hs-CRP and HRV.Results HRV parameters of type 2 DM patients were significantly lower than those of non-diabetic patients,but hs-CRP values were significantly higher than those of control.Linear correlation analysis indicated that HRV was in a positive correlation with hs-CRP in type 2 diabetic aged patients.Conclusion Altered autonomic nervous function may be associated with altered serum hs-CRP in aged patients with type 2 diabetes mellitus.

AIM:To establish the quality standards for Qinghuo Tablets(Folium Isatidis,Radix et Rhizoma Rhei,Gypsum Fibrosum,etc.). METHODS:Folium Isatidis,Radix et Rhizoma Rhei,menthol in Qinghuo Tablets were identified by TLC.Indirubin and emodin were determined by HPLC.Agilent-ODS-3(5 ?m,4.6 mm?250 mm) column was used.The column temperature was at 25 ℃.Methanol-0.5% H_3PO_4(75∶25) was used as a mobile phase.The detection wavelength was at 289 nm.The flow rate was 1.0 mL/min. RESULTS:Folium Isatidis,Radix et Rhizoma Rhei,menthol could be detected by TLC.Indirubin showed a good linear relationship at the range of 0.071 4-0.714 ?g,r=0.999 7.The average recovery was 98.95%,and RSD was 0.57%.Emodin showed a good linear relationship at the range of 0.204-2.04 ?g,r=0.999 8.The average recovery was(99.01%),and RSD was 0.79%. CONCLUSION:The established method is rapid,accurate,reproducible with a strong specificify.

Far beyond simulating manual work with the computer system,hospital informatization entails a combination of information technology with hospital professional work.With a fully understanding of working procedure in hospital,an effective concordance based on informatization requirements is conducted so that the management and the collection of the information can follow the information flow,logistics,capital flow,working flow and organization flow.Management mode and organization framework of the hospital are also adjusted.Thus the hospital operation quality and efficiency are improved,and patients are offered seamless and continuous service,which really reflects the service theory: "Patient First".

A backup data center near the primary data center using Storage Area Network is built with Fiber Channel technology. The specific disaster recovery software used to synchronize the two centers a highly reliable safety and expandable data storage management system with adequate redundancy is developed. Thus disaster recovery service can be provided for the hospital information system when disaster happens. To avoid the system risk and maintain the continuity of the hospital's activities the damaged part of the system will be taken over from.

Several models about epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)as first-line treatment in advanced NSCLC show different results.Combination with chemotherapy and EG-FR-TKIs did not indicate survival advantage.However,sequential chemotherapy in EGFR-TKIs and a single agent of EGFR-TKIs as first-line treatment of advanced NSCLC have made tremendous breakthrough,and give a new path in individual treatment of advanced NSCLC.Also EGFR mulatious in targeted therapy of advanced NSCLc has a sood predictive value of the etticacy.

AIM: To develop a method of determining notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 in Naomaitai Capsules(Radix et Rhizoma Ginseng Rubra,Radix et Rhizoma Notoginseng,Radix Angelicae Sinensis,etc.) by HPLC. METHODS: Notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 were determined by HPLC gradient elution method,Inertsil-ODS-3(5 ?m 4.6 mm?250 mm) column with Acetonitrile-water as the mobile phase was used for gradient elution.The flow rate was at 1.0 mL/min and the detective wavelength was at 203 nm.The column temperature was at 35 ℃. RESULTS: There was a good linear relationship at a range of 0.205-1.539 ?g for notoginsenoside R_1(r=0.999 6),the average recovery of 98.07%, and RSD of 0.51%(n=5),0.838-6.285 ?g for ginsenoside Rg_1(r=0.999 4),the average recovery of 97.66%,and RSD of(0.53%)(n=5),0.822-6.165 ?g for ginsenoside Rb_1(r=0.999 6),the average recovery of 98.19%,and RSD of 0.44%(n=5). CONCLUSION: The method is simple,reproducible and accurate with a strong specificify,and can be used for the quality control of Naomaitai Capsules.

Adult ; Citric Acid ; adverse effects ; Dust ; Humans ; Male ; Middle Aged ; Occupational Exposure ; adverse effects ; Tooth Erosion ; chemically induced

Objective To study the CT appearances of primary pulmonary histoplasmosis (PPHP)and evaluate the diagnostic values of CT for PPHP.Methods The clinical materials and multi-slice spiral CT appearances in 8 patients with PPHP proved pathologically were reviewed retrospectively.Results Single or multiple pneumonia-like lesions were seen in 3 esses,single or multiple nodules or masses were in 4 cases,and both pneumonia-like lesions and nodules or mflsses in 1 case.Calcification and halo sign were common,and only slight enhancement was demonstrated after intravenous contrast administration on CT.Conclusion CT is helpful imaging method in the diagnosis and differential diagnosis of PPHP combining with clinical materials although the CT appearances are not specific.

Objective To observe the nursing effect of closed needle-free style injection connector in endoscopic nasobiliary drainage (ERCP). Methods From June 2013 to June 2014, 400 patients of the common bile duct stones underwent ERCP technique and placed nasobiliary were divided into two groups according to chronological. Between June 1st, 2013 and December 20th, 200 patients were set as control group, between December 21th, 2013 and June 30, 2014, 200 patients were set as experimental group. For the control group, the nasobiliary duct was directedly connected to the disposable drainage bag. For the experimental group, the nasobiliary duct was connected to closed needle-free style injection connector, and then to the drainage bag. The incidences of the detached connection, the fracture of the connection with the nasobiliary duct, bile leakage from the connection, and post-ERCP infection were compared between two groups. Results The incidence of bile leakage, crack pipes, separation and postoperative infection occurred at the junction nasobiliary rates in the experimental group were 0,0,0,2%(4/200), which were far lower than 35% (70/200),11% (22/200), 6% (12/200), 6%(12/200) of the control group. The difference was statistically significant (χ2=31.75~169.60, P < 0.01). Conclusions The application of closed needle-free style injection connector can effectively avoid the detachment and fracture of the connection, the occurrence of bile leakage, and post-ERCP infection. This will be helpful to decrease the burden of nursing care and increase patients′satisficationdegree.

Peking University Third Hospital was cited as an example in this paper to study how to guide public opinion and build a harmonious doctor-patient relationship by using WeChat official platform.It pointed out that the public relations office of the hospital should keep track of the ongoing healthcare reform,and leverage the functions of mass media,improve professionalism of their media workers,and build a long-term mechanism to response to public opinions in time.