Humanistic education is the important content of college quality education.But the humanistic education in our country is very weak,and the university students are short of humanistic spirits at large,which goes against the improvement of the quality of university students and higher education.So our universities should enhance humanistic education,which should be the keystone of stratage for each university from ideas to practice.

Objective To explore the correlation between serum homocysteine (Hcy) level and diabetes mellitus combined with cerebral infarction (DMCI) in patients. Methods A total of 144 patients with type 2 diabetes mellitus (T2DM) were selected and divided into two groups, patients without cerebral infaction (group A, n=64) and patients with cerebral infaction (group B, n=80). Thirty healthy people were used as control group (group C). The serum Hcy level was detected by enzymatic cycling assay in three groups. The serum levels of cholesterol (TC) and triglyceride cholesterol (TG) were detected by enzymatic determination. The serum levels of high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were detected by homogeneous phase method. The serum level of creatinine (Cr) was detected by creatine oxidase method. The level of uric acid (UA) was detected by urinary enzyme peroxidase coupling method. Glycosylated hemoglobin (HbA1c) was detected by high performance liquid chromatography. The carotid artery intima media thickness (IMT) was examined by color Doppler ultrasound, and patients were divided into mild and no stenosis group, moderate stenosis group and severe stenosis group according to the
results. The levels of Hcy were compared between all groups. The correlation of Hcy level and other indicators was analyzed. Results The levels of Hcy and HbA1c were group C0.05). There were no significant differences in UA and Cr levels between the three groups (P>0.05). The level of Hcy was positively correlated with age (rs=0.411), HbA1c (rs=0.219) and Cr (rs=0.242), and negatively correlated with gender (rs=-0.202) and HDL-C (rs=-0.278, P<0.05). There were no significant correlation between Hcy level and other variables (P>0.05). With the increased degree of carotid artery stenosis, the Hcy level and the proportion of HHcy showed a rising trend in patients (P<0.01). The level of Hcy was positively correlated with IMT(rs=0.781, P<0.001). Conclusion Hcy is a risk factor for the onset of DMCI. The high level of Hcy is closely related to the occurrence and progression of atherosclerosis. Hcy has great value for early screening and prevention of DMCI.

OBJECTIVE To find out the situation of the use of preventive application of antimicrobial in orthopedic perioperative patients and to evaluate the rationality of use. METHODS To make a survey of the use of antimicrobials in orthopedic perioperative patients during Apr-Jun 2004 and to evaluate the kinds,frequency,combined administration,course,effectiveness,etc. RESULTS 99.2% patients had received antimicrobials involving 14 kinds.62.8% from them used one.34.5% used two and 2.7% used three. CONCLUSIONS It is necessary to strengthen the management of preventive antimicrobial in orthopedic patients during perioperative period.

OBJECTIVE:To study the occurrences of adverse drug reactions(ADR)in our hospital for references of rational use of drugs in the clinic.METHODS:A total of 377 ADR cases collected in our hospital during the period 2005～2006 were analyzed statistically in respect of patients' age and sex,drug kinds,clinical manifestations and route of administration etc.RE-SULTS:Of the total 377 ADR cases,the number of drug kinds involved totaled 118,with antiinfective drugs taking the lead,accounting for 46.61%(55 kinds),283 cases were given intravenously.Lesions of skin and the appendants were the chief ADR types(49.87%);there were 17 severe cases.CONCLUSION:Great importance should be attached to ADR monitoring in the clinic.

4.0 cm,the extension living time and elevation survival rate were better in palliative surgery operation than RFA treatment.However,RFA treatment has lower complications rate and higher postoperation quality of living.

Objective To investigate the assessments from family member and nurse for nursing care needs of critical patients based on the Maslow's hierarchy of needs. Methods Questionnaires regarding nursing care needs of critical patients were designed according to the Maslow′s hierarchy of needs; these questionnaires were performed to family members and nurses, and the results were analyzed. Results There was difference regarding the order of various needs of critical patients between family members and nurses; compared to nurse, family members had significantly higher scores on love and belongingness need [(4.08±0.72) points vs. (3.44±0.63) points, t=5.61, P<0.01], and had obviously lower scores on safety needs [(3.71±0.62) points vs. (3.92±0.69) points, t=2.18, P<0.05]. Conclusions The asymmetry in assessments from family member and nurse for nursing care needs of critical patients exist objectively;during clinical nursing, communication with family members should enhance and provide humanized services and management measures should be adopted to improve family members′satisfaction towards nursing service.

BACKGROUND: The effective fraction of stem and leaf of Scutellaria baicalensis, total flavones from stem and leaf of Scutellaria baicalensis (SSTF) can improve blood flow of coronary artery and cerebral blood flow,prolong the time of cruor and prothrombin and decrease blood lipid.OBJECTIVE: To observe the effect of SSTF on blood pressure of normal rats and rat models of renal artery stenosis.DESIGN: A completely randomized and controlled experiment.SETTING: Institute of Traditional Chinese Medicine, Chengde Medical College (Key Laboratory of Research and Exploiture of Traditional Chinese Medicine in Hebei Province) MATERIALS: Totally 70 Wistar rats, aged 2 months old , of clean degree, with body mass of (250±50) g, male and female in half, with permission number of 01-3003 , were provided by the Experimental Animal Research Institute, Chinese Academy of Medical Sciences. SSTF was provided by the phytochemical laboratory of Institute of Traditional Chinese Medicine, Chengde Medical College; Niuhuangjiangya pian was produced by Shiyitang Pharmaceutical Factory, Hayao Company (batch number:9802304).METHODS: The experiment was conducted in Institute of Traditional Chinese Medicine, Chengde Medical College from January to October 1999. The rats were raised in the environment of (22±1) ℃, with relative humidity of 50%-55%, of daylight and darkness for 12 hours for each. ①In the experiment 1, we studied the effect of SSTF on the blood pressure of normal rats. Totally 30 Wistar rats were randomly divided into SSTF group of 100 mg/kg (n=10, 100 mg/kg SSTF), SSTF group of 50 mg/kg (n=10, 50 mg/kg SSTF), and normal saline control group (n=10, 0.5 mL /100 g normal saline). Before being administrated, rats were anaesthetized by intraperitoneal injection of pentobarbital sodium. Blood pressure was recorded by MecLab/4e four-channel physiologic instrument. Then intragastric administration of SSTF and normal saline were performed on the rats in SSTF groups and normal saline control group respectively. Thirty minutes later, the changes of blood pressure of rats in each group were observed successively. ②In the experiment 2, we studied the effect of SSTF on the blood pressure of model rats with hypertension induced by renal artery stenosis. The rest 40 Wistar rats were randomly divided into SSTF group of high dosage, SSTF group of low dosage, normal saline control group, Niuhuangjiangya pian group, with 10 rats in each group. Rats in each group were created into rat models with hypertension induced by renal artery stenosis according to methods from the literatures. Two weeks after operation, intragastric administration of 100 mg/kg SSTF, 50 mg/kg SSTF, 0.5 mL/100 g normal saline and 1 200 mg/kg Niuhuangjiangya pian were daily performed on the rats in four groups respectively for one month successively. Carotid blood pressure of rats in all groups was measured.MAIN OUTCOME MEASURES: ① The effect of SSTF on the blood pressure of normal rats. ②The effect of SSTF on the blood pressure of model rats with hypertension induced by arteria renalis stenosis.RESULTS: ① Effect of SSTF on the blood pressure of normal rats: Blood pressure of SSTF group of 50 mg/kg and SSTF group of 100 mg/kg presented a little decrease compared with before administration. There was no significant difference when compared with normal saline control group (P ＞ 0.05). ②Effeet of SSTF on the blood pressure of model rats with hypertension induced by arteria renalis stenosis: Blood pressure of rats with hypertension in normal saline control group was significantly increased after modeling; Blood pressure of rats with hypertension in SSTF group of 50 mg/kg , SSTF group of 100 mg/kg and Niuhuangjiangya pian group was significantly lower than that in the normal saline control group, especially significantly in SSTF group of 100 mg/kg [(126.3±14.5),(120.2±15.9),(127.8 ±23.4 ) ,(139.6±15.8) mm Hg; P ＜ 0.05-0.01].CONCLUSION: SSTF has the significant hypotensive effect on model rats with hypertension; it does not have obvious effect on normal rats.

Objective To study the percentage of HBV specific CD3 + T cells in the peripheral blood of chronic hepatitis B patients. Methods HLA A 2 patients were screened by MHC:Ig dimer reagent. HLA A 2 restricted HBV core, polymerase, and surface peptides were added to T cells of chronic hepatitis B patients, followed by double staining with anti CD3 antibodies and antibodies reactive with the heavy chain of Ig. FACS was used for monitoring HBV specific T cell percentage. Results 23/54 (42.6%) patients belonged to HLA A 2. Fifteen of them were reacted with HBV peptides. CD3 + T cells of five patients showed higher percentage of binding with the HBV peptides than that in the controls. Four patients showed CD3 + T cells binding with S peptide, one with P peptide and one binding with both S and P peptide. Conclusions The percentage of T cells which could bind with HBV peptide was low in chronic hepatitis B and the binding efficiency was low as well. The MHC:Ig dimer reagent is convenient for counting the number of HBV specific T cells, but the nonspecific staining background seems to be relatively high. However, this technology is useful to monitor changes of immune responses in chronic hepatitis B patients during immuno therapy.