AIM： On the basis of in vitro study， a preliminary survey of the stability of diclofenac lysine sustained-release tables(DLST) was carried out to identify the period of validity.METHODS： To observe the changes of DLST under high temperature， blaze， high humidity and room temperature(for long period) and to perform accelerating test for 3 months.RESULTS： The drug release was accelerated under high temperature， and the tablet was apt to absorb moisture because of its hydrophilic matrix and the drug release became faster at day 10 under blaze， and therefore DLST should be stored away from high temperature， high humidity and blaze.CONCLUSION： DLST is stable and the period of validity is tentatively fixed at 2 years.

Objective To explore the application of seasonal time series ARIMA model in prediction of malaria incidence in an unstable malaria area. Methods SPSS13.0 software was used to construct the ARIMA model based on the monthly malaria incidence of Huaiyuan and Tongbai counties in Huaihe River Valley, from Jan. 1998 to Dec. 2005, with consideration of residual un-correlation and concision. Akaike′s information criterion (AIC) and Bayesian information criterion (BIC) were used to confirm the fitness of model. The constructed model was then applied to predict the monthly malaria incidence in 2006 and the incidence from ARIMA model was compared with the actual incidence, so as to evaluate the model′s validity. Malaria incidence of 2007 was predicted by ARIMA model based on malaria incidence from 1998 to 2006. Results Statistics assisted estimation of the significance of the fitted autoregressive and seasonal moving average coefficients (AR1=0.512, SMA1=0.609, P

Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason under-lying difculties in tumor treatment and failure of a number of current therapeutic modalities, even of molecularly targeted therapies. The development of a virtually noninvasive“liquid biopsy”from the blood has been attempted to characterize tumor heterogeneity. This review focuses on cell-free circulating tumor DNA (ctDNA) in the bloodstream as a versatile biomarker. ctDNA analysis is an evolving field with many new methods being developed and optimized to be able to successfully extract and analyze ctDNA, which has vast clinical applications. ctDNA has the potential to accurately genotype the tumor and identify personalized genetic and epigenetic alterations of the entire tumor. In addition, ctDNA has the potential to accurately monitor tumor burden and treatment response, while also being able to monitor minimal residual disease, reducing the need for harmful adjuvant chemotherapy and allowing more rapid detection of relapse. There are still many challenges that need to be overcome prior to this biomarker getting wide adoption in the clinical world, including optimization, standardization, and large multicenter trials.

T lymphocyte subset and NK cells in the blood of SCI patients were measured by APAAP(Alkaline Phosphatase Antialkaline Phosphatase) in order to study the change of immune function in SCI patients.The results showed that cell mediated and non specific immune function in SCI patients was decreased. It plays a role in the rehabilitation of SCI patients to increase immune function.

One hundred and fourty-nine normal persons were tested to gain the normal scale of Comprehensive Function Evaluation(CFE).It includes seven items eighteen categories.The result demonstrated that fifteen categories of normal persons in age of twenty to sixty-nine incuding understanding and expressing,feeding,grooming,dressing clothes,dressing trousers and skirts,bathing,bowel and bladder management,control of sphincter of bowel and bladder,bed wheelchair mobility,bathtub-wheelchair mobility,ambulation,up and down the stairs,which gained one hundred degrees each,memory ninty eight to one hundred degrees,problem solving ability eighty-four to one hundred degrees,social communication ninty-nine to one hundred degrees.We conclude preliminarily:CFE is an individual ability evaluation of preson,demonstrating the comprehensive function of presons which were in aga of twenty to sixty nine,educated in and above primary school.It can be used as a main scale to evaluate the guality and effect of rehabilitation sequence,and has practical value to improve rehabilitation medical level.

Objective To investigate the safety and efficacy of intravenous thrombolytic therapy with recombinant tissue plasminogen activator(rtPA)in patients with isolated penetrating artery territory infarct (IPAI).Methods Data of retrospectively collected clinical,laboratory,and radiological from 75 consecutive patients with acute ischemic stroke treated with intravenous rtPA therapy from June 2009 to April 2011.Etiological classification was carried out according to the Chinese Ischemic Stroke Classification of Subgroups(CISS).The rates of hemorrhagic transformation(HT)and clinical outcomes of patients were compared between IPAI group and non-IPAI group.Results All 75 patients with mean age of 67.4years and 25(33.3％)fenale,were treated with intravenous rtPA.Before treatment,their average score of the National Institutes of Health Stroke Scale(NIHSS)was 12.3 ± 6.4,and mean length of time from onset to treatment was 239.6 ±97.5 minutes.After thrombolytic therapy,the radiological HT was found in 24 patients(32％).Symptomatic intracraneal hemorrhage(ICH)occurred in 4 patients(5.3％).Of 22 (29.3％)patients with IPAI,only one experienced HT.Logistic regression analysis suggested that IPAI wasan individualized predictor used alone for determining the low risk of HT.In the patients with IPAI,82％ of them had an individual clinical outcome(mRS ＜ 2)one month after onset,and the neurological outcomes were better in patients with IPAI than those in patients with non-IPAI(P ＜ 0.01).Conclusions The risk of hemorrhagic complication was low and the clinical outcome was good in patients with isolated penetrating artery territory infarct after intravenous thrombolytic therapy with rtPA.Imaging diagnosis of IPAI might facilitate the treatment with rtPA in this cohort of patients.

: Rehabilitation medicine is a medical branch which focused on functional recovery. Function Evaluation is very important in assessing the function of patients, the effect of treatment and the efficiency of rehabilitation. Comprehensive Function Evaluation includes evaluation of physical, psychological, speech and society. Vocal, mental and social evaluation have deep cultural and national background. Therefore every country must have its own Function Evaluation Method. Now we present our design for Comprehensive Evaluation. Based on the cooperation of Department of Rehabilitation, Department of Neurology, Department of Spinal Cord Injury, Department of Speech Therapy and Department of Psychology. The advantages of this method are as follows: 1. The style of ADL, speech and thinking are suitable for the condition of our country. 2. The evaluation result adopts hundred work system, it is easy for medical staff, patients and their family to understand and communicate the result. 3. We make it more accurate, comprehensive and reliable by some simple tests on speech pathology and psychology. 4. We overcome some disadvantages of evaluation indexes because it is not correct and is difficult to be understood before. Now every evaluation index has quantity standard. 5. It is simple and practical. Each subtest takes 20 minutes or more. 6. It has been tested by normal people. The norm and severity grade had been developed. 7. The reliability is tested and is proved to be dependable.

康复医学是以恢复患者功能为中心的医学分支。因此，功能评定无论是在客观地评定患者的功能方面，还是在最终评定治疗结果和康复效率方面都是极为重要的。全面的功能评定包括躯体、精神、言语和社会四个方面。其中，言语、社会功能和认知功能中的思维方式，都具有强烈的民族文化色彩。因此，每个国家都应该有切合自己国情的功能评定方法。但由于我国康复医学发展较晚，至今尚无一套既切合国情，又全面、实用和可靠的功能评定方法。有鉴于此，我们在“中心”顾问室、神经康复科、脊髓损伤康复科、言语治疗科、心理科和老年病科的通力合作下，经过近2年的研究，在吸收国际先进经验的基础上，密切结合国情，设计了本文所述的综合功能评定法。其优点有：1．在饮食、起居等生活方式方面以及在言语、社会、思维等方面，均切合我国国情。2．评定结果采用群众熟悉的100分制，使医务人员、患者和患者家属均易于理解，便于交流和沟通。3．在言语、认知等功能的评定方面，直接由言语和心理学家选择一些简易的言语和心理学测试项目，提高了量表的准确性、全面性和可靠性。4．各项评定指标的量化程度高，在言语、认知和社会方面尤其如此，克服了一些量表中对此类项目的评定指标不够具体和不易掌握的不足。5.简便实用，一次检查对正常人仅需20分钟左右，对患者则无负担。6.本法已在128名正常人中应用，并求出了正常值，据此拟定了功能障碍严重程度的等级，可供参考和应用。7.信度经过检验，证明可靠。 综合功能评定法的正常值、功能障碍严重程度分级及信度研究结果，将陆续报道。

Objective To investigate the impact of selective ulnar artery continuous circulatory compression in reducing radial artery occlusion in elderly patients undergoing coronary intervention for coronary artery disease.Methods A total of 450 elderly patients with coronary heart disease undergo-ing coronary intervention were selected as study objects,and were randomly divided into control group and experimental group,with 225 patients in each group.The control group received non-occlusive ra-dial artery compression postoperatively,while the experimental group underwent selective ulnar arteria continuous circulatory compression using a customized pulse wave sphygmomanometer on the basis of the control group for a duration of 4 hours.Puncture site bleeding,pain,thumb skin temperature,nursing workload,delayed pressure measurement rate,radial artery blood flow velocity,and rates of radial artery occlusion and stenosis were compared between the two groups 24 hours postoperatively.Results There were no significant differences in puncture site bleeding,pain,thumb skin tempera-ture,nursing workload,and delayed pressure measurement rate between the two groups(P＞0.05).However,the experimental group presented significantly faster radial artery blood flow velocity 0.5 hours before removing the blood pressure monitor,as well as lower rates of radial artery occlusion and stenosis 24 hours post operatively compared to the control group(P＜0.05).Conclusion The use of a blood pressure monitor for selective continuous circulatory compression for a duration of 4 hours can enhance radial artery blood supply and reduce rates of postoperative radial artery occlusion and stenosis in elderly coronary intervention patients under the premise of not increasing the risk of bleeding,pain,nurse workload and delayed pressure extraction.

Objective To investigate the impact of selective ulnar artery continuous circulatory compression in reducing radial artery occlusion in elderly patients undergoing coronary intervention for coronary artery disease.Methods A total of 450 elderly patients with coronary heart disease undergo-ing coronary intervention were selected as study objects,and were randomly divided into control group and experimental group,with 225 patients in each group.The control group received non-occlusive ra-dial artery compression postoperatively,while the experimental group underwent selective ulnar arteria continuous circulatory compression using a customized pulse wave sphygmomanometer on the basis of the control group for a duration of 4 hours.Puncture site bleeding,pain,thumb skin temperature,nursing workload,delayed pressure measurement rate,radial artery blood flow velocity,and rates of radial artery occlusion and stenosis were compared between the two groups 24 hours postoperatively.Results There were no significant differences in puncture site bleeding,pain,thumb skin tempera-ture,nursing workload,and delayed pressure measurement rate between the two groups(P＞0.05).However,the experimental group presented significantly faster radial artery blood flow velocity 0.5 hours before removing the blood pressure monitor,as well as lower rates of radial artery occlusion and stenosis 24 hours post operatively compared to the control group(P＜0.05).Conclusion The use of a blood pressure monitor for selective continuous circulatory compression for a duration of 4 hours can enhance radial artery blood supply and reduce rates of postoperative radial artery occlusion and stenosis in elderly coronary intervention patients under the premise of not increasing the risk of bleeding,pain,nurse workload and delayed pressure extraction.