Objective:To explore the effect between Xuezhikang and rosuvastatin on carotid intima-media thickness (IMT) .Methods :A total of 90 patients with carotid atherosclerosis were randomly and equally divided into control group ,Xuezhikang group and rosuvastatin group according to number table .After six-month treatment ,changes of blood lipid levels and IMT were compared among three groups .Results:Compared with before treatment ,there were significant improvements in blood lipid levels (except high density lipoprotein cholesterol ) and IMT after six months in Xuezhikang group and rosuvastatin group , P<0.05~ <0.01 ;compared with control group after treat-ment ,there were significant reductions in levels of triglyceride [ (2.12 ± 0.97) mmol/L vs .(1.17 ± 0.47) mmol/L , (1.87 ± 0.97) mmol/L] ,total cholesterol [ (5.95 ± 0.65) mmol/L vs . (5.14 ± 0.71) mmol/L ,(4.75 ± 0.64) mmol/L] and low density lipoprotein cholesterol [LDL-C , (3.64 ± 0.45 ) mmol/L vs . (3.01 ± 0.51 ) mmol/L , (2.15 ± 0.55) mmol/L] ,IMT [ (1.15 ± 0.15) mm vs .(1.01 ± 0.08) mm , (0.98 ± 0.02) mm] and total plaque score [ (6.10 ± 2.12) scores vs .(4.61 ± 2.08) scores , (4.59 ± 2.34) scores] in Xuezhikang group and rosuvastatin group , P<0.05~ <0.01 .After treatment ,there were no significant difference in above indexes between Xuezhi-kang group and rosuvastatin group ( P> 0.05 all) except that LDL-C level of rosuvastatin group was significantly lower than that of Xuezhikang group ( P< 0.05 ) .Conclusion:Both Xuezhikang and rosuvastatin can significantly improve carotid atherosclerosis ,and their therapeutic effects are equal .

Objective: To investigate the findings of coronary artery angiography in coronary artery disease patients with diabetes mellitus. Methods: The angiographic fingings of 153 coronary artery disease patients from 1995 to 1997 were reviewed. Among them, 33 were diabetic,23 were impaired glucose tolerance(IGT) and 97 were nondiabetic patients. Results: The age, sex, hypertension, hypercholesterolemia, smoking and the rate of myocardial infarction were the same among 3 groups. But the 2 vessel and 3 vessel disease were more frequent in diabetic group(66.7% ,30.3%) than in nondiabetic group (26.8%,19 6%). Two vessel disease were more frequent in diabetic group(66.7%) than in IGT group (13.1%). Single vessel disease were less frequent in diabetic group(3.0%) than in IGT group(52.2%)and nondiabetic group(53.6%)( P

Growth of tumor need new blood vessel to meet the demand for adequate oxygen and nutri -ents.Inhibiting the formation of blood vessel can inhibit growth of tumor .In all of the endogenous angiogenesis in-hibitors deriving from the type IV collagen .Study of tumstatin is the most widely .Tumstatin can inhibit endothelial proliferation and induce the apoptosis of endothelial cell .This article reviews the research status of the tumstatin .

Objective To observe the effect of Du moxibustion health care underwear intervention effects on quality of life and immunity of sub-health Yang deficiency.Methods Sub healthy Yang deficiency subjects were randomly divided into observation group and control group,30 cases in each group.The observation group in Du moxibustion health care underwear for 12 weeks,the control group in ordinary clothes,with quality of life scale (SF-36) to observe the change of their integral quality of life energy,physical function,emotional function and mental health of four indicators,IgA and IgG in blood were detected by scatter turbidity rate method.Flow cytometry was used to detect CD4+ and CD8+ in blood.Results The scores of physiological function,energy,emotional function and mental health in the observation group were significantly higher than those in the control group (P＜0.01).The levels of IgA,IgG and CD4+ in bservation group were significantly higher than those before,and CD4+ was lower,and the difference were statistically significant when compared with the control group(P＜0.05,P＜0.01).Conclusion Du moxibustion health care underwear sub-health Yang deficiency can improve their quality of life and immunity.

Objective To explore the auditory P300 potentials in rehabilitated male patient of heroin addicts (MPHD),as well as the change of P300 amplitude in the drug craving state.Methods Rehabilitated MPHD patients (n =20) and healthy controls (n =20) underwent standard auditory P300 test.Only the patient group completed auditory P300 test after viewing neutral video and drug craving video respectively.Results Rehabilitated MPHD patients showed reduction of P300 amplitude (Cz:(2.72 ± 1.90) μV vs (3.99 ± 1.74) μV ; Pz:(4.48 ± 1.87) μV vs (5.61 ± 1.39) μV ; P ＜ 0.05) than that of healthy controls in standard auditory P300 test.Patients who had been successfully induced by drug craving video demonstrated higher P300 amplitude (Pz:(5.00± 1.68) μV vs (4.19 ± 1.62) μV; P＜0.05) after viewing drug craving video than that of viewing neutral video.Conclusion MPHD patients have cognitive impairment in their rehabilitation period;and P300 index can partially reflect the attention change in patients' drug craving state.

ObjectiveToanalyzetheclinicalandimagingcharacteristicsinpatientswithcarotidsteal syndrome ( CSS ) and to investigate its compensatory pathw ays, diagnosis, and treatment. Methods The medical history and imaging data of the patients with CSS were colected. Their vascular lesions, colateral circulation, treatment, and prognosis w ere analyzed. Results A total of 11 patients w ith CSS (8 males and 3 females, mean age 66.7 ±5.1 years) were enroled in the study. Their clinical manifestations were posterior circulation transient ischemic attack (TIA) ( n=9, 81.8%), posterior circulation infarction ( n=1, 9.1%), and anterior circulation TIA ( n=1, 9.1%). A total of 19 pathological arteries w ere found:12 (63.1%) w ith occlusion, 2 (10.5%) w ith subtotal occlusion, 4 (21.0%) w ith severe stenosis and 1 (5.2%) w ith artery dissection. Seven patients (63.6%) w ere bilateral internal carotid artery lesions, 3 (27.2%) w ere unilateral bilateral internal carotid artery lesions, and 1 (9.1%) w as bilateral common carotid artery occlusion. Eleven patients had primary col ateral circulation, including posterior communicating artery patency in 10 patients (90.9%) and anterior communicating artery patency in 1 patient (9.1%). Four patients (36.3%) had secondary col ateral circulation and 1 (9.1%) had tertiary col ateral circulation. Al patients w ere treated w ith medication on the basis of the management of risk factors. Three patients w ere treated w ith stenting and tw o were treated with carotid endarterectomy. No stroke occurred in al patients during folow -up til September 2014. Conclusions The vascular lesions of patients w ith CSS often occur in the extracranial segment of internal carotid artery. Usual y the compensatory blood is through the circle of Wil is. The presentation is ischemia in the stolen arteries. Its diagnosis needs to be examined by digital subtraction angiography. On the basis of medication therapy, some patients may be treated w ith surgery or endovascular intervention.

Objective: To investigate the effect of quercetin on hepatic ischemia reperfusion injury (HIRI) in rats.Methods: Quercetin was administered intragastrically. Vitamin C was used as positive control. HIRI was induced by blocking and then releasing portal vein and hepatic artery in rats. The hepatic content of quercetin was analyzed by HPLC. Plasma GPT, GOT activities, MDA concentration and hepa-tic GSH and MDA contents, GSH-Px, SOD, XO activities, total antioxidant capacity (TAOC), ROS, DNA fragmentation were measured.Results: After HIRI, plasma GPT, GOT activities and MDA concentration were increased significantly. Hepatic GSH and TAOC were decreased remarkably. The activities of SOD and GSH-Px were significantly decreased while XO activity, ROS production and DNA fragmentation increased. Intragastric administration of quercetin increased hepatic quercetin and decreased ROS production and plasma activities of GPT, GOT and MDA concentration. Hepatic GSH and SOD, GSH-Px activities and TAOC also recovered remarkably, but no significant change in DNA fragmentation. Vitamin C was also effective in protecting against HIRI. Conclusion: Quercetin is effective against HIRI. The mechanism is associated with increased hepatic antioxidant capacity.

Objective To discuss the difference of cognitive function in patients of first-episode schizophrenia with and without metabolic syndrome.Methods Event related potential detection and Wechsler Memory Scale (WMS) was determined in 57 patients of first-episode schizophrenia with metabolic syndrome (research group) and 57 patients of first-episode schizophrenia without metabolic syndrome (control group),and the psychiatric symptom in two groups was assessed by the application of the positive and negative symptoms scale (PANSS).Results The memory quotient score was (78.51 ± 12.54) scores in research group,and (92.01 ± 17.49) scores in control group,and there was significant difference between two groups (t =-2.130,P=0.047).The short-term memory,instantaneous memory impairment in research group were lower than those in control group(t =2.151-3.054,P=0.007-0.046).The latency of P300 was (325.10 ±22.46) ms in research group and (284.60 ±22.46) ms in control group,and there was significant difference (t =3.454,P =0.003).The amplitude was (6.56 ± 1.61) μ V in research group and (9.78 ±1.73) μV in control group,and there was significant difference (t =-4.307,P =0.000).Conclusion The patients of first-episode schizophrenia with metabolism syndrome has more severe cognitive impairment than those without metabolism syndrome.

Background Corneal collagen cross-linking (CXL) shows good clinical effects for keratoconus,and de-epithelized CXL appears to be benefit to the distribution and absorption of riboflavin in cornea stroma.However,de-epithelization of CXL will increase the infective risk and corneal healing time.It is very important to understand and control the affecting factors of corneal repair after de-epithelization of CXL.Objective This study was to evaluate the characteristics of corneal epithelial repair and analyze the relevant factors affecting corneal healing time after de-epithelized CXL.Methods A series-cases observational study was performed.De-epithelized CXL was performed on 77 eyes of 68 keratoconus patients in Shandong Eye Hospital from September 2013 to September 2015 under the approval of Ethic Committee of this hospital and informed consent of each patient.The age,corneal curvature,corneal thickness,breakup time of tear film (BUT),corneal front astigmatism (Astig) and epithelial healing time of the patients were recorded after surgery.The correlations between corneal epithelium healing time and above-mentioned factors were analyzed.Results De-epithelized CXL was smoothly finished in all the eyes.The corneal epithelium healing time was 2-12 days after surgery,with the average healing time 5 (4,6) days.The mean age,thickness at corneal thinnest point,minimal cornea curvature (Kf),maximal corneal curvature (Ks),corneal average curvature (Km) and Astig was 22.00 (18.00,25.00) years,436 (412,470) μm,47.40 (44.70,50.45) D,52.10 (49.00,54.55) D,50.00 (47.15,53.15) D and-3.30 (-5.45,1.70) D,respectively.Spearman rank correlation analysis showed significant negative correlations between corneal epithelium healing time and BUT or the thickness at corneal thinnest point (BUT:rs =-0.334,P =0.003;corneal thickness:rs =-0.417,P =0.000),and thesignificant positive correlations were found between corneal epithelium healing time and Km,Kf and Ks (Km:rs =0.449,P =0.000;Kf:rs =0.300,P =0.008;Ks:rs =0.432,P =0.000).There were no considerable correlarions between corneal epithelium healing time and age or Astig (age:rs =0.023,P =0.845;Astig:rs =-0.190,P =0.098).Multiple linear regression analysis were carried out to study the dependent variable and independent factors.Because of the multiple co-linearity between variables,this paper corrects the model by using ridge regression.There is significant negative correlation between BUT,corneal thickness and corneal healing time,respectively (both at P＜0.05),corneal curvature Km and Kf is positively correlated with corneal healing time (both at P ＜ 0.05).Conclusions The corneal thickness,Kf,Km,as well as BUT are influencing factors of epithelial healing after CXL.

Objective To study the mechanism underlying attentional biases toward event-related potentials (ERPs) in healthy male subjects.Methods 18 male healthy subjects performed emotional stroop task by pressing the buttons to the picture border color of two categories including the neutral and positive.The RT and Accuracy were recorded automatically.The ERPs were recorded by Neuroscan system.Results The behavioral results showed that neither the reaction time (628.11 ± 55.46) ms vs (628.81 ± 53.92) ms nor accuracy (96.87 ± 4.42) ％ vs (95.76±7.41)％ found difference under two conditions.ERPs results showed that the positive pictures evoked more greater P2 ((8.16±4.99)μV vs (4.30±3.83)μV) and P3 ((6.31±4.53)μV vs (4.27±4.16)μV) than neutral pictures.Conclusion Attentional biases toward positive emotion can be found in healthy male subjects,which can be related to emotional control process.