1.Hematometra Due to Cervical Stenosis in a Postmenopausal Woman with Incidental Ovarian Steroid Cell Tumor: A Case Report
Yong Jin PARK ; Ju Hee KIM ; Jihye KOH
Journal of Menopausal Medicine 2022;28(3):142-145
Vaginal bleeding is reported among 4%–11% of postmenopausal women. Hematometra is commonly associated with cervical stenosis due to senile atrophy, radiotherapy, or a uterine neoplastic lesion in women of postmenopausal age. Ovarian steroid cell tumor is a rare hormone-secreting tumor subtype accounting for approximately 0.1% of all ovarian tumors. Here we report a case of hematometra in a postmenopausal woman with high estrogen levels who was later diagnosed with a steroid cell tumor.
2.Radiation-induced Myositis after Proton Beam Therapy to Huge Hepatocellular Carcinoma
Jihye KIM ; Gyu Sang YOO ; Dong Hyun SINN ; Hee Chul PARK ; Kwang Cheol KOH
Journal of Liver Cancer 2019;19(2):136-142
Proton beam therapy (PBT) is one of the advances in radiotherapy techniques, which enables dose escalation with lower probability of radiation-induced liver or gastrointestinal injuries. However, the chest wall proximal to the tumor can be affected by high dose irradiation. Here, we report on a 58-year-old male patient who presented with huge hepatocellular carcinoma, received treatment with transarterial chemoembolization and PBT, and developed severe chest wall pain due to radiation-induced myositis. The patient's symptoms were controlled by oral steroids.
Carcinoma, Hepatocellular
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Humans
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Liver
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Male
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Middle Aged
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Myositis
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Proton Therapy
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Protons
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Radiotherapy
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Steroids
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Thoracic Wall
3.Various Types of Fetal Arrhythmias and Assessment of the Cardiac Function in a Fetus with a Cardiac Capillary Hemangioma: A Case Report
Jihye KOH ; Myung Shin SHIN ; Byeol HAN ; Jinha LEE ; Hye-Sung WON
Perinatology 2024;35(2):76-80
We present a case of fetal cardiac hemangioma that caused fetal arrhythmia and reduced ventricular contractibility. At 31 weeks and 1 day of gestation, a 29-year-old primiparous mother was referred to our institution due to an abnormal ultrasound finding, suspicious of a fetal cardiac mass occupying the right atrium (RA). The blood flow from the RA to the right ventricle (RV) was decreased. Additional evaluation through FetalHQ (GE Healthcare Korea) revealed diminished RV contractility. At gestational age 35 weeks and 1 day, the fetus had developed paroxysmal supraventricular tachycardia. We decided to perform an emergency cesarean section to prevent further impairment in fetal cardiac circulation. Postnatal echocardiography showed a pedunculated mass on the free wall of the RA, and the cardiac movements were affected with atrial flutter. Immediate mass excision was performed.Pathological analysis confirmed that the mass was a juvenile capillary hemangioma. The newborn stayed admitted for postoperative care and recovered healthy without any signs of cardiac arrhythmia.
4.Various Types of Fetal Arrhythmias and Assessment of the Cardiac Function in a Fetus with a Cardiac Capillary Hemangioma: A Case Report
Jihye KOH ; Myung Shin SHIN ; Byeol HAN ; Jinha LEE ; Hye-Sung WON
Perinatology 2024;35(2):76-80
We present a case of fetal cardiac hemangioma that caused fetal arrhythmia and reduced ventricular contractibility. At 31 weeks and 1 day of gestation, a 29-year-old primiparous mother was referred to our institution due to an abnormal ultrasound finding, suspicious of a fetal cardiac mass occupying the right atrium (RA). The blood flow from the RA to the right ventricle (RV) was decreased. Additional evaluation through FetalHQ (GE Healthcare Korea) revealed diminished RV contractility. At gestational age 35 weeks and 1 day, the fetus had developed paroxysmal supraventricular tachycardia. We decided to perform an emergency cesarean section to prevent further impairment in fetal cardiac circulation. Postnatal echocardiography showed a pedunculated mass on the free wall of the RA, and the cardiac movements were affected with atrial flutter. Immediate mass excision was performed.Pathological analysis confirmed that the mass was a juvenile capillary hemangioma. The newborn stayed admitted for postoperative care and recovered healthy without any signs of cardiac arrhythmia.
5.Various Types of Fetal Arrhythmias and Assessment of the Cardiac Function in a Fetus with a Cardiac Capillary Hemangioma: A Case Report
Jihye KOH ; Myung Shin SHIN ; Byeol HAN ; Jinha LEE ; Hye-Sung WON
Perinatology 2024;35(2):76-80
We present a case of fetal cardiac hemangioma that caused fetal arrhythmia and reduced ventricular contractibility. At 31 weeks and 1 day of gestation, a 29-year-old primiparous mother was referred to our institution due to an abnormal ultrasound finding, suspicious of a fetal cardiac mass occupying the right atrium (RA). The blood flow from the RA to the right ventricle (RV) was decreased. Additional evaluation through FetalHQ (GE Healthcare Korea) revealed diminished RV contractility. At gestational age 35 weeks and 1 day, the fetus had developed paroxysmal supraventricular tachycardia. We decided to perform an emergency cesarean section to prevent further impairment in fetal cardiac circulation. Postnatal echocardiography showed a pedunculated mass on the free wall of the RA, and the cardiac movements were affected with atrial flutter. Immediate mass excision was performed.Pathological analysis confirmed that the mass was a juvenile capillary hemangioma. The newborn stayed admitted for postoperative care and recovered healthy without any signs of cardiac arrhythmia.
6.Various Types of Fetal Arrhythmias and Assessment of the Cardiac Function in a Fetus with a Cardiac Capillary Hemangioma: A Case Report
Jihye KOH ; Myung Shin SHIN ; Byeol HAN ; Jinha LEE ; Hye-Sung WON
Perinatology 2024;35(2):76-80
We present a case of fetal cardiac hemangioma that caused fetal arrhythmia and reduced ventricular contractibility. At 31 weeks and 1 day of gestation, a 29-year-old primiparous mother was referred to our institution due to an abnormal ultrasound finding, suspicious of a fetal cardiac mass occupying the right atrium (RA). The blood flow from the RA to the right ventricle (RV) was decreased. Additional evaluation through FetalHQ (GE Healthcare Korea) revealed diminished RV contractility. At gestational age 35 weeks and 1 day, the fetus had developed paroxysmal supraventricular tachycardia. We decided to perform an emergency cesarean section to prevent further impairment in fetal cardiac circulation. Postnatal echocardiography showed a pedunculated mass on the free wall of the RA, and the cardiac movements were affected with atrial flutter. Immediate mass excision was performed.Pathological analysis confirmed that the mass was a juvenile capillary hemangioma. The newborn stayed admitted for postoperative care and recovered healthy without any signs of cardiac arrhythmia.
7.Various Types of Fetal Arrhythmias and Assessment of the Cardiac Function in a Fetus with a Cardiac Capillary Hemangioma: A Case Report
Jihye KOH ; Myung Shin SHIN ; Byeol HAN ; Jinha LEE ; Hye-Sung WON
Perinatology 2024;35(2):76-80
We present a case of fetal cardiac hemangioma that caused fetal arrhythmia and reduced ventricular contractibility. At 31 weeks and 1 day of gestation, a 29-year-old primiparous mother was referred to our institution due to an abnormal ultrasound finding, suspicious of a fetal cardiac mass occupying the right atrium (RA). The blood flow from the RA to the right ventricle (RV) was decreased. Additional evaluation through FetalHQ (GE Healthcare Korea) revealed diminished RV contractility. At gestational age 35 weeks and 1 day, the fetus had developed paroxysmal supraventricular tachycardia. We decided to perform an emergency cesarean section to prevent further impairment in fetal cardiac circulation. Postnatal echocardiography showed a pedunculated mass on the free wall of the RA, and the cardiac movements were affected with atrial flutter. Immediate mass excision was performed.Pathological analysis confirmed that the mass was a juvenile capillary hemangioma. The newborn stayed admitted for postoperative care and recovered healthy without any signs of cardiac arrhythmia.
8.Effects of irradiation and leukoreduction on down-regulation of CXCL-8 and storage lesion in stored canine whole blood
Hayoung YANG ; Woosun KIM ; Junwoo BAE ; Hyunwoo KIM ; Sangki KIM ; Jihye CHOI ; Jinho PARK ; Dong In JUNG ; HongBum KOH ; DoHyeon YU
Journal of Veterinary Science 2019;20(1):72-78
White blood cells (WBCs) and storage period are the main factors of transfusion reactions. In the present study, cytokine/chemokine concentrations after leukoreduction (LR) and irradiation (IR) in stored canine whole blood were measured. Red blood cell storage lesion caused by IR and LR were also compared. Blood samples from 10 healthy Beagles were divided into four groups (no treatment, LR-, IR-, and LR + IR-treated). Leukocytes were removed by filtration in the LR group and gamma radiation (25 Gy) was applied in the IR group. Immunologic factors (WBCs, interleukin-6 [IL-6], C-X-C motif chemokine ligand 8 [CXCL-8], and tumor necrosis factor-alpha) and storage lesion factors (blood pH, potassium, and hemolysis) were evaluated on storage days 0, 7, 14, 21, and 28. Compared to the treated groups, IL-6 and CXCL-8 concentrations during storage were significantly higher in the control (no treatment) group. LR did not show changes in cytokine/chemokine concentrations, and storage lesion presence was relatively mild. IR significantly increased CXCL-8 after 14 days of storage, but IR of leukoreduced blood did not increase CXCL-8 during 28 days of storage. Storage lesions such as hemolysis, increased potassium, and low pH were observed 7 days after IR and storage of blood, regardless of LR. IR of leukoreduced blood is beneficial to avoid immune reactions; however, storage lesions should be considered upon storage.
Blood Preservation
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Down-Regulation
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Erythrocytes
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Filtration
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Gamma Rays
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Hemolysis
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Hydrogen-Ion Concentration
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Immunologic Factors
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Interleukin-6
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Leukocyte Reduction Procedures
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Leukocytes
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Necrosis
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Potassium
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Transfusion Reaction
9.Potential etiology, prevalence of cirrhosis, and mode of detection among patients with non-B non-C hepatocellular carcinoma in Korea
Jihye KIM ; Wonseok KANG ; Dong Hyun SINN ; Geum-Youn GWAK ; Yong-Han PAIK ; Moon Seok CHOI ; Joon Hyeok LEE ; Kwang Cheol KOH ; Seung Woon PAIK
The Korean Journal of Internal Medicine 2020;35(1):65-78
Background/Aims:
We systematically evaluated the clinical characteristics, prevalence of cirrhosis, and mode of detection in virus-unrelated (non-B non-C, NBNC) hepatocellular carcinoma (HCC) patients in Korea.
Methods:
A total of 447 consecutive treatment-naïve NBNC-HCC adult patients who were registered at the Samsung Medical Center HCC registry in Korea from 2010 to 2013 were analyzed. NBNC was defined as negative hepatitis B surface antigen and negative anti-hepatitis C virus antibody. Presence of cirrhosis was determined based on histological, radiological, endoscopic, and serologic results. Mode of detection was classified as either under surveillance, incidental, or symptomatic.
Results:
Heavy alcohol use was the most common potential etiology in NBNCHCC (NBNC-A, alcohol) (59.7%). Ten patients had other identifiable causes (NBNC-O, other identifiable cause) such as autoimmune hepatitis. The rest (38.0%) had no-identifiable cause (NBNC-NA-NO, non-alcohol, no-other identifiable cause). In NBNC-NA-NO group, 83.5% (96/115) of patients with available hepatitis B core immunoglobulin G antibody (HBcIgG) showed HBcIgG positivity, and 80.6% (137/170) had metabolic risk factors (diabetes, obesity, hypertension, and/ or dyslipidemia). Cirrhosis was present in 90.0%, 70.4%, and 60.0% of NBNC-O, NBNC-A, and NBNC-NA-NO patients, respectively. The proportion of patients diagnosed under surveillance was 25.5% across all patients, with specific proportions being 80.0%, 27.7%, and 18.8% for NBNC-O, NBNC-A, and NBNC-NA-NO, respectively.
Conclusions
Among NBNC-HCC patients, heavy alcohol use or any other identifiable cause was not found in 38.0%. These NBNC-NA-NO HCC patients showed a high prevalence of HBcIgG positivity and metabolic risk factors, suggesting that prior hepatitis B virus infection and metabolic risk factors may be major contributing factors in the hepatocarcinogenesis in NBNC-NA-NO patients.
10.The Effect of Formula-based Nutritional Treatment on Colitis in a Murine Model
Sooyoung JANG ; Younjuong KIM ; Changjun LEE ; Bomi KWON ; Jihye NOH ; Jai J. JEE ; Sang Sun YOON ; Hong KOH ; Sowon PARK
Journal of Korean Medical Science 2021;36(50):e342-
Background:
Exclusive enteral nutrition (EEN) induces remission in pediatric Crohn's disease (CD). The exact mechanism of EEN therapy in CD is unknown, but alteration of the intestinal microflora after EEN is thought to affect mucosal healing. To determine the link between EEN therapy and therapeutic efficacy in CD, we established a murine model of dextran sulfate sodium (DSS)-induced colitis and applied EEN therapy.
Methods:
Eight-week-old C57BL/6 mice were administered DSS for 4 days to induce colitis, and either normal chow (NC) or EEN was administered for the following 4 days. The mice were grouped according to the feeding pattern after DSS administration: DSS/NC and DSS/ EEN groups. The clinical course was confirmed via daily observation of the weight and stool. Fecal samples were collected and 16sRNA sequencing was used. The mice were sacrificed to confirm colonic histopathology.
Results:
Weight reduction and increase in disease activity were observed as the day progressed for 4 days after DSS administration. There was significant weight recovery and improvement in disease activity in the EEN group compared to that in the NC group. Verrucomicrobia and Proteobacteria abundances tended to increase and Bacteroidetes abundance decreased in the EEN group. In the EEN group, significant changes in the β-diversity of the microbiota were observed. In the analysis of microbiome species, abundances of Akkermansia muciniphila, Clostridium cocleatum, mucin-degrading bacteria, Flintibacter butyricus, and Parabacteroides goldsteinii, which are beneficial microbiota, were significantly increased in the EEN group compared to those in the NC group. More abundant mucins were confirmed in the colonic histopathology of the EEN group. These microbial and histopathological differences suggested that EEN might improve colitis symptoms in a murine colitis model by promoting mucin recycling and subsequently inducing the healing effect of the gut barrier.
Conclusion
EEN showed clinical efficacy in a murine model of colitis. Based on the increase in mucin-degrading bacteria and the pathological increase in mucin production after EEN administration, it can be observed that mucin plays an important role in the therapeutic effect of EEN.