Objective To study the effect of licorice on the pharmacokinetics of lovastatin in hyperlipidemic rat model.Methods Eighteen rats were randomly divided into control group (n =6) and test group (n =12).Rats in the test group were administered high fat diet to construct hyperlipidemic rat model.The 12 hyperlipidemic rats were then randomly divided into two groups:lovastatin group (n =6) and lovastatin combined with hcorice group (n =6).The rats in both groups were administered lovastatin capsule (20 mg/kg,0.5％ CMC-Na solution) after receiving licorice (for lovastatin combined with licorice group) or saline (for lovastatin group) for 7 days.Blood samples were collected at different time points before and after the administration of lovastatin capsule.The plasma concentrations of lovastatin and lovastatin acid (an active metabolite of lovastatin) were determined by LC-MS/MS method.Pharmacokinetics parameters were calculated using DAS 2.0 software,and the two groups were compared using SPSS 18.0 software.Results Long-term administration of licorice resulted in a significant increase in the plasma level of lovastatin acid in the hyperlipidemic rat,and the corresponding mean Cmax was approximately 80％ higher than that of the lovastatin group (P ＜ 0.05),while AUC0-t and AUC0-t increased by 115％ and 109％,respectively (P =0.005 and P =0.027).Cmax and AUC of lovastatin also increased,but there was no statistical significance (P ＞ 0.05).Conclusion Licorice can inhibit the metabolism of lovastatin in hyperhpidemic rats and increase its exposure in vivo.

Objective To investigate the effect of warfarin on the formation of renal calcium oxalate stones induced by 1% ethylence glycol (EG) and 3% ammonium chloride (NH 4Cl) in rats. Methods 30 adult male Wistar rats were randomized to three groups,the control group (A) being non-treated,the stone group (B) rats taken EG and NH 4Cl,and the warfarin group (C) taken warfarin in addition to EG and NH 4Cl.All rats were bred 4 weeks.The renal tissue calcium,the renal calcium oxalate crystallization,and the urinary calcium excretion and serum biochemical data were detected. Results No significant difference has been noted in 3 groups,although there is a tend that number of ranal calcium oxalate crystals in group C was more than that in group B. Conclusions The results denoted that warfarin had no significant effect on the calcium oxalate crystallization in rats.

Risk of radiation limits the use of radioactive isotopes in humans and the use the stable isotopes increases. The improvement of the mass spectrometers has resulted in the development of a variety of approaches for measuring rates of protein synthesis.Currently, two methods (constant infusion method and flooding method)have been extensively used.

Sepsis causes marked derangements in the flow of glutamine among organs.During sepsis,skeletal muscle exhibits increase in glutamine release which is associated with a significant increase in endogenous glutamine biosynthesis.However, the release rates exceed that of synthesis.The liver appears to be the major organ of glutamine uptake,the bowel displays a decrease in glutamine utilization and the cells of the immune system are also major glutamine consumers.

Objective To explore the change of the activities of peroxisome ?-oxidation in T2DM patients with the lipid disorders.Methods We analyzed the changes of the activities of peroxisome ?-oxidation and fatty acyl-CoA oxidase and its mRNA expression in 112 cases of T2DM patients.Results We found that there was compensatory increase in activity of peroxisome ?-oxidation of T2DM patients.As compared with control group,the activity of fatty acyl-CoA oxidase of T2DM group was increased by 5%(P

Objective To evaluate short-term curative effect of chloroquine combined with traditional Chinese medicine in treatment of erosion lichen planus. Methods 40 cases were chosen and randomly divided into two groups. The treatment group included 20 cases were treated with chloroquine combined with traditional Chinese medicine. The control group with 20 cases was treated only with chloroquine. The curative effect of the two groups were compared. Results Comparing the two groups, in the treatment group, the pain was remarkably relieved and the erosion areas were obviously smaller. Significant changes were observed statisticly. The overall effectiveness of the treatment group was 85% ,but that of the control group was 65%. Conclusion The treatment of chloroquine combined with traditional Chinese medicine have a short-term clinical effect on erosion lichen planus.

Objective To investigate the method for benefit management of medical equipment. Methods By analyzing the actuality of equipment management, problems were founded and the solutions were discussed. Results The problems are the repeated purchase of medical equipment, less use in some equipments, dis- accordance among equipment, card and account. Conclusions In hospital, medical equipment play a crucial role in medical affairs, teaching and scientific research, and can bring prominent economic benefit. Enhancing the scientific management in medical equipment, emphasizing the details, procedure and scientific investigation in management can promote the using efficiency, ensure the reasonable match in equipment as much as possible in order to make the hospital sustainable development.

Objective\ To evaluate the efficacy of atrial lead implantation during atrial fibrillation.Methods\ In 10 patients(group A),the atrial leads were implanted during atrial fibrillation and the sensing and pacing parameters before and after restoring to sinus rhythm were compared with the parameters of patients whose atrial leads were implanted during sinus rhythm (group B).Results\ During follow-up,the sensing and pacing parameters were measured,and there were no significant difference between group A and B.In group A,mean atrial potential amplitude during atrial fibrillation was correlated with the telemetered atrial potential amplitude during sinus rhythm.Conclusion\ Atrial lead implantation during atrial fibrillation is feasible.

Objective To inquire into T-type calcium channel effects on RyR and IP 3R of sarcoplasmic reticulum in atrial myocytes during atrial fibrillation.Methods Ten dogs underwent continuous rapid atrial pacing (500 beats/min) to create persistent atrial fibrillation.In five rapidly-paced dogs,mibefradil dihydrochloride was given beginning 2 days after pacemaker implantation,continuing until the twenty-fourth week.A group of size-matched dogs (n=5) without given mibefradil was used as a pure atrial fibrillation group.Another group of size-matched dogs (n=5) without pacemaker implantation was used as a control group.Canine atrial myocytes isolated by enzymatic dissociation were used to study T-type Ca 2+ channel blocker effects on expression and function changes of RyR and IP 3R in atrial myocytes by confocal microscopy.Results RyR/IP 3R ratio (0.2965?0.01812) was markedly lower than that of control group (2.7043?0.2293),but there was no difference compared with that of atrial fibrillation group (0.2472?0.1355).Ca 2+transient of atrial myocytes was nremarkably changed (1.3031?0.1056)(P

Rheumatoid arthritis (RA) , an autoimmune disease, become much popular in recent years. In this article, apoptosis of RA fibroblast like synovial cells and influence factors in this process were discussed, and the relating signal transduction pathway of RA fibroblast apoptosis was described.