Melanoma inhibitory activity protein(MIA),also referred to as cartilage-derived retinoic acid-sensitive protein(CD-RAP),is expressed not only in malignant melanoma,but also in chondrocytes.MIA/CD-RAP act as a biological marker for the evaluation of the status of cartilage in the study of cartilage destruction.This article reviews the biochemistry,construction,physiological function of MIA/CD-RAP in cartilage destruction and the research progress in these aspects.

Objective To investigate the clinical effect of Shaoyao Gancao Decoction (SGD) combined with conventional therapy in treatment of neck cervical spondylosis.Methods 119 cases of neck cervical spondylosis from Jiaxing Hospital of Zhejiang Armed Police Hospital during January 2013 to January 2015 were retrospective analysis, 68 patients were treated with SGD combined with conventional physical therapy (combination group), 51 patients were only adapted conventional physical therapy (physiotherapy group).The clinical efficacy between two groups were compared.Results After treatment, the cervical curvature, neck pain, neck tenderness, cervical flexing function,cervical lateral curvature function,affect the condition of work, the impact of the disease on sleep scores of combination group were significantly lower than physiotherapy group (P<0.05).NPQ and McGill scores of two groups were significantly lower than pre-treatment ( P<0.05 ) , and NPQ, McGill scores of combined group were significantly lower than physiotherapy group (P<0.05).Therapy cure rate of combined group was 32.35%, which higher than 19.61%of physiotherapy group (P<0.05). Conclusion SGD combined with conventional therapy in treatment of neck cervical spondylosis was better than conventional therapy alone.

Objective:To observe the effect of total knee arthroplasty in the treatment of knee osteoarthritis.Methods:From April 2017 to April 2019, 80 patients with knee osteoarthritis admitted to Zhejiang Rongjun Hospital were selected in the research.The patients were divided into control group(40 cases) and observation group(40 cases) according to the random digital table method.The control group was operated by arthroscopy, and the observation group was operated by total knee replacement.The bleeding volume, incision healing time, hospitalization time, incidence of postoperative complication, knee joint activity, VAS score and HSS score were compared between the two groups.Results:The amount of bleeding in the observation group was (137.26±30.85)mL, which was less than that in the control group[(300.31±58.40)mL]( t=15.613, P<0.001). The healing time of incision and hospitalization time in the observation group were (4.20±1.37)d and (7.58±1.20)d, respectively, which were shorter than those in the control group[(6.89±2.43)d and (10.50±3.20)d], the differences was statistically significant( t=6.099, 5.404, all P<0.001). The incidence of postoperative complications in the observation group was 7.50%(3/40), which was lower than 25.00%(10/40) in the control group(χ 2=4.501, P<0.05). The knee joint mobility of the observation group was (106.71±15.38)° after operation, which was higher than that of the control group[(95.51±11.62)°]( t=3.675, P<0.001). The VAS score and HSS score of the observation group were (2.50±0.68)points and (89.27±5.65)points, which were better than those of the control group[(4.53±0.71)points and (69.39±5.41)points], the differences were statistically significant( t=13.059, 16.073, all P<0.001). Conclusion:Total knee arthroplasty is effective in the treatment of knee osteoarthritis, which is helpful for the recovery of knee function.