Bitter taste in the mouth is a prevalent clinical symptom that refers to a spontaneous bitterness in the mouth after excluding external factors such as diet,and belongs to the phantogeusia of dysgeusia.The etiology and mechanism of bitter taste in the mouth re-main unclear.Studies have shown that bitter taste in the mouth is mainly associated with multiple factors such as diseases,medications and nutrition.In addition,effective and reliable treatments have also not yet been developed.This paper reviews the latest research ad-vances in the etiology,mechanism and treatment of bitter taste in the mouth,with the aim of providing reference for the clinical man-agement of patients with mouth bitterness.