Objective To study the efficacy and adverse reactions for renal transplant patients conversed from cyclospo-rine A to tacrolimus .Methods The follow-up data of renal transplant patients conversed from cyclosporine A to tacrolimus were collected .The clinical therapeutic outcomes including drug induced diseases (DIDs) and acute rejection (AR) induced by cyclosporine A were analyzed during the first year after conversion with SPSS 17 .0 software .Results The levels of Scr and BUN were significantly decreased during the first year after conversion for renal transplant patients with CScr and AR (P<0.05 or P<0 .01) .The levels of direct bilirubin (DB) and total bilirubin (TB) were also significantly lowed (P<0.05 or P<0 .01) during the first year for drug-induced liver injury (DILI) patients .The average level of ALT was significantly decreased in 12 months after conversion (P<0.05) .The complications of gingival overgrowth (GO) stopped with the medication replace-ment .However ,the fasting blood glucose (FBG) level increased significantly in 12 months after conversion (P<0.05) .Con-clusion For renal transplant patients suffered from AR or the serious DIDs induced by cyclosporine A ,conversion from cyclos-porine A to tacrolimus could be considered .However ,it should be aware of the high blood glucose or the new diabetes caused by tacrolimus .

OBJECTIVETo study the diagnosis and treatment of prostate cancer after prostatectomy for benign prostatic hyperplasia (BPH).

METHODSTwelve cases of prostate cancer after prostatectomy for benign prostatic hyperplasia were reviewed and studied. The mean intervals between prostatectomy for BPH and the diagnosis of prostate cancer was 10 months to 14 years, 5.6 years on average. The main symptoms were dysuria, hematuria and pain. Serum prostate specific antigen (PSA) was elevated in 11 cases. Digital rectal examination (DRE) was abnormal in 8 cases. Three cases were in clinical stage B, 3 in stage C and 6 in stage D. Ten cases received combined androgen blockade therapy. Monotherapy with surgical castration was given to 2 cases. Three patients with urinary tract obstruction received additional treatment of TURP.

RESULTSDuring the 4 months to 8 years follow-up, 3 patients died, 6 remained stable and 2 deteriorated.

CONCLUSIONSurgery for BPH could not prevent the development of prostate cancer. PSA and DRE were the main methods for the diagnosis of this prostate cancer.

Aged ; Aged, 80 and over ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Postoperative Complications ; Prostate-Specific Antigen ; blood ; Prostatic Hyperplasia ; surgery ; Prostatic Neoplasms ; diagnosis ; Retrospective Studies ; Transurethral Resection of Prostate

Objective To explore the effect of aerobic exercise on Wnt/β-Catenin pathway in the cerebral cortex and hippocampus of rats,so as to provide theoretical basis for conforming that aerobic exercise can improve the function of the nervous system.Methods Six-week-old Sprague-Dawley male rats were randomly assigned to a sedentary control group (CG) and an aerobic exercise group (EG).The rats in the EG group underwent an 8-week treadmill training and their cerebral cortex and hippocampus were isolated at 48h after the last exercise.The mRNA levels of Wnt,β-Catenin,LRP5,LRP6,Axin1,CK1 and GSK3β were analyzed using quantitative PCR,while the protein and phosphorylation levels were assayed using Western blotting.Results After 8 weeks of treadmill exercise,the average mRNA and protein levels of Wnt1 and Wnt3 in the EG group were significantly higher than those in the CG group.Although there were no significant differences in β-Catenin mRNA levels between EG and CG groups,the protein levels of β-Catenin in the EG group were significantly higher than those in the CG group.Meanwhile,the phosphorylation levels of β-Catenin Ser33/Ser37 and Thr41/Ser45 were significantly lower than those in the CG group.In the EG group,the mRNA and protein levels of LRP5 and LRP6 were significantly higher than those in the CG group,while those of Axin1 and CK1 were significantly lower than the CG group.Moreover,no significant differences were observed in the mRNA and protein levels of GSK3β between the two groups,but the phosphorylation levels of GSK3β Ser9 in the EG group were significantly higher than the CG group.Conclusion Aerobic exercises can increase the levels of Wnt and Wnt receptor,protein LRP5 and LRP6,decrease the levels of Axin1 and CK1,inhibit the activity of GSK3β,altogether lowering the pbosphorylation of β-Catenin to promote the stableness of β-Catenin.Therefore,the aerobic exercise can increase Wnt/β-Catenin pathway activity and activate the downstream gene transcription in the cerebral cortex and hippocampus of rats.

OBJECTIVES: In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging. METHODS: Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.2% male) aged 20 and above, OBS and PhenoAgeAccel were calculated. Weighted generalized linear regression models were employed to explore the associations between OBS and PhenoAgeAccel, including a sex-specific analysis. RESULTS: The OBS demonstrated significant variability across various demographic and health-related factors. There was a clear negative correlation observed between the higher OBS quartiles and PhenoAgeAccel, which presented sex-specific results: the negative association between OBS and PhenoAgeAccel was more pronounced in male than in female. An analysis using restricted cubic splines revealed no significant non-linear relationships. Interaction effects were noted solely in the context of sex and hyperlipidemia. CONCLUSIONS A higher OBS was significantly associated with a slower aging process, as measured by lower PhenoAgeAccel. These findings underscore the importance of OBS as a biomarker in the study of aging and point to sex and hyperlipidemia as variables that may affect this association. Additional research is required to confirm these results and to investigate the biological underpinnings of this relationship.