Objective To explore the effect of nursing procedure on pressure sore in patients with brain tumor.Methods The nursing procedures were used in the nursing of 86 brain tumor patients.The procedures included assessment of pressure ulcer risk factors and regulations of nursing objective and the measures for preventing pressure ulcer.Result None of the patients contracted pressure ulcer during operation.Conclusion The nursing procedures for brain tumor patients can enable the nurses to plan nursing activities for specific purpose,avoid the occurrence of pressure sore and thus improve the quality of nursing.

Objective To explore the effects of improved emergency nursing intervention on complications and clinical prognosis of severe patients with craniocerebral injury accompanied by cerebral hernia, and provide evidence for clinical nursing. Methods The patients with severe craniocerebral injury accompanied by cerebral hernia were enrolled in Dongguan People's Hospital from January 2016 to December 2018. According to the admission time, the patients were divided into routine nursing group (Admission from January 2016 to June 2017) and improved emergency nursing methods group (Admission from July 2017 to December 2018). To analyze the effect of two different nursing methods on the prognosis of patients by improving first aid nursing measures and routine nursing. Both groups of patients underwent craniotomy, the conventional nursing group was treated with routine operating room care, the improved emergency nursing methods group was given improved emergency care interventions based on the conventional nursing, the operation preparation time, operation time, intra-operative blood loss and the incidence of postoperative complications, clinical prognosis of the two groups were observed; the self-made questionnaire was used to evaluate the scores of the patient's satisfaction and compliance. Results The operation preparation time, operation time and intra-operative blood loss of the improved emergency nursing methods group (40 cases) were significantly lower than those in the conventional nursing group [40 cases, operation preparation time (minutes): 25.03±5.47 vs. 36.73±5.83, operation time (minutes): 52.56±10.63 vs. 92.10±10.73, intra-operative blood loss (mL): 218.73±20.74 vs. 402.66±23.70, all P < 0.05]; the clinical good prognosis rate, rate of satisfaction to nursing, treatment compliance score of the improved emergency nursing methods group were significantly higher than those of the conventional nursing group [clinical good prognosis rate: 20.0% (8/40) vs. 12.5% (5/40), rate of satisfaction to nursing: 95.0% (38/40) vs. 82.5% (33/40), treatment compliance scores: 95.83±4.09 vs. 81.27±5.04, all P < 0.05]; the complication rate of the improved emergency nursing methods group was significantly lower than that of the conventional nursing group [32.5% (13/40) vs. 55.0% (22/40), P <0.05]. Conclusion The improved emergency nursing intervention can significantly improve the clinical prognosis and reduce the incidence of complications in patients with severe craniocerebral injury accompanied by cerebral hernia, so that the clinical application value is relatively high.

Therapeutic drug monitoring is a good interpretation of personalized medicine, which helps to improve the safety and effectiveness of patient medication. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gradually been widely accepted by clinical laboratories due to its characteristics of specificity, sensitivity, and flexibility in method development. This article introduces the importance and analytical techniques for therapeutic drug monitoring, describes the application and development of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring, new advances in the detection of different drug types and sample types, and challenges in automation, convenience, and standardization.

Therapeutic drug monitoring is a good interpretation of personalized medicine, which helps to improve the safety and effectiveness of patient medication. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gradually been widely accepted by clinical laboratories due to its characteristics of specificity, sensitivity, and flexibility in method development. This article introduces the importance and analytical techniques for therapeutic drug monitoring, describes the application and development of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring, new advances in the detection of different drug types and sample types, and challenges in automation, convenience, and standardization.

To examine the feasibility of using a computer tool for stratifying the severity of Coronavirus Disease 2019 (COVID-19) based on computed tomography (CT) images. We retrospectively examined 44 confirmed COVID-19 cases. All cases were evaluated separately by radiologists (visually) and through an in-house computer software. The degree of lesions was visually scored by the radiologist, as follows, for each of the 5 lung lobes:0, no lesion present;1,<1/3 involvement;2,>1/3 and<2/3 involvement;and 3,>2/3 involvement. Lesion density was assessed based on the proportion of ground-glass opacity (GGO), consolidation and fibrosis of the lesions. The parameters obtained using the computer tool included lung volume (mL), lesion volume (mL), lesion percentage (％), and mean lesion density (HU) of the whole lung, right lung, left lung, and each lobe. The scores obtained by the radiologists and quantitative results generated by the computer software were tested for correlation. A Chi-square test was used to test the consistency of radiologist- and computer-derived lesion percentage in the right/left lung, upper/lower lobe, and each of the 5 lobes. The results showed a strong to moderate correlation between lesion percentage scores obtained by radiologists and the computer software (r ranged from 0.7679 to 0.8373, P < 0.05), and a moderate correlation between the proportion of GGO and mean lesion density (r=-0.5894, P<0.05), and proportion of consolidation and mean lesion density (r=0.6282, P<0.05). Computer-aided quantification showed a statistical significant higher lesion percentage for lower lobes than that assessed by the radiologists (x2 = 8.160, P = 0.004). Our experiments demonstrated that the computer tool could reliably and accurately assess the severity and distribution of pneumonia on CT scans.

Objective:To explore the current cognition of sustained-released (SR) and controlled-release (CR) oral drugs in patients with type 2 diabetes mellitus (T2DM) who have been contracted with general practitioners, analyze the problems and causes in the patients' drug use, and put forward suggestions and countermeasures.Methods:Totally 400 T2DM patients using SR and CR oral drugs, who have been contracted with general practitioners from Yuetan Community Healthcare Center in Xicheng District and Xinhua Community Healthcare Center in Tongzhou District of Beijing were selected by convenient sampling in May 2019, and investigated with the self-designed SR and CR cognition questionnaire for T2DM patients. The patients' cognition and influencing factors of drug use were analyzed.Results:The correct answer rate of the six items in the SR and CR oral drug questionnaire among the 400 patients was 55.3%-59.3%. The correct answer rate of patients aged 41-60 years was higher than that of patients aged over 60 years; the correct answer rate of patients with higher educational levels was higher than that of patients with lower educational levels; and the correct rate of patients who met blood glucose standards was higher than that of patients who did not meet blood glucose standards, and the differences were statistically significant ( P < 0.01) . Conclusions:Diabetic patients contracted with general practitioners have a low level of understanding of SR and CR oral drugs. Individualized guidance based on the patients' own conditions is conducive to their cognition and correct use rate of SR and CR drugs.

Objective To observe the stability of orthostatism and weight-bearing position,and range of motion (ROM) of vertical plane and coronal plane of thoracic vertebrae through measuring spinal forms before and after standing exercise,and explore the corrective effect of standing exercise on spine unbalance.Methods The university students (n =30) were chosen as subjects,and divided into test group and control group.After standing exercise,the changes of thoracic intervertebral angles of spinal orthostatism and weight-bearing position,anterior flexion and posterior extension of vertical plane,and left bending and right bending of coronal plane were measured by using spinal measurement apparatus in 2 groups.The measurement results were compared.Results The comparison results showed that the stability of 2 spinal positions and ROM of vertical plane and coronal plane had significant differences between 2 groups (P ＜ 0.05).The ROM of coronal plane had greatly significant difference in test group before and after standing exercise (P ＜0.001),and that has no difference in control group at the same time points.Conclusion The differences in the stability and ROM of thoracic vertebrae indicate that standing exercise can adjust the form of spine and correct spine unbalance.

Objective To analyze and explore the gender-dependent differences of the psychological adjustment induced by baduanjin(eight-trigram boxing)by comparing the total and spatial changes of β1 and β2 electroencephalogram(EEG)power among male and female college students before and after per-forming baduanjin.Methods College students were recruited as volunteers,and were divided into male and female groups.All volunteers received baduanjin training.β1 and β2 EEG power of two groups was measured and compared with NT9200 electroencephalograph before and after performing baduanjin.The results were collected to analyze the differences of absolute power in two groups before and after baduanjin training.Results General comparison:the absolute power of the β1 and β2 band in the female group was significantly higher than that in the male group before training (P >0.05).The absolute power of the β1 and β2 band increased significantly in the male group after training (P >0.01).There was no sig-nificant difference in the female group before training(P >0.05).In addition,there was no significant difference between male group and female group in the absolute power of the β1 and β2 band after train-ing (P >0.05).Spatial comparison:there were significant differences in the distribution of β1 and β2 bands on the EEG between male and female groups before training.Compared with the distribution of β1 and β2 in different groups before training,the distribution of β1 on different groups tended to be consist-ent after training.The distribution of β2 band presented an increasing tendency on the whole brain region after training,while the female group presented decreasing tendency on most brain regions after training. Function coordination of left and right cerebral hemispheres:compared with EEG before training,the cor-relation between right and left cerebral hemispheres shown on β1 and β2 band increased significantly or changed from negative to positiv correlation.Conclusion Psychological adjustment may be induced by baduanjin,and it has the effects of removing differences of physiological movement between male and fe-male volunteers.In other words,when students perform baduanjin,mental and physiological movement in brain presents with similar pattern.