Lnk is a member of a newly discovered adaptor protein family.It negatively regulates the Jak-STAT,Ras/MAPK,PI3K signaling pathways.Lnk plays a critical role in hematopoiesis,endothelial cell activation and actin cytoskeleton regulation.This article aims to review the progress of Lnk adaptor protein.

Objective To explore the possibility of early definitive operation for enteric fistulas. Methods In 37 selected enterocutaneous fistula patients, early definitive operation was performed during laparotomy for treating peritonitis within 10 days of fistula formation. Thorough irrigation of peritoneal cavity, effective sump drainage, fibrin glue sealant to reinforce anastomosis, appropriate nutritional support, and administration of growth hormone were key elements of perioperative management. Results Among 37 patients, 35 of them recovered uneventfully. Fistula recurred in 2 cases postoperatively; one fistula closed after conservative management, and another patient died of advanced gastric cancer 3 months postoperatively. The fistula operative closure rate was 94.5%. No operative death. Conclusion Advances in perioperative management can promote the success rate of early definitive operation for enteric fistulas. It may become a challenge to the present strategy of enteric fistula management.