Objective:To build a performance appraisal system for full-time researchers in specialized children′s hospitals, so as to mobilize their enthusiasm and improve their efficiency of scientific and technological output.Methods:Based on structure-process-result model, the library of indexes was initialized by such means as literature review and talent performance appraisal management experiences. From November 2020 to March 2021, Delphi method was adopted to finalize the appraisal indexes and weight of each index, while the quantifiable standards of the indexes were formulated by brainstorming, hence establishing the performance appraisal model index system for these researchers. Using both the new model and the original performance appraisal system of the hospital respectively, five full-time research staffs of research-oriented children′s hospital were selected for an empirical research on performance appraisal.Results:Fifteen experts carried out two rounds of Delphi research, finalizing a performance appraisal model for these researchers. The model comprises 3 level-1 indexes, 8 level-2 indexes and 23 level-3 indexes. Among them, the weight of scientific research output, scientific research process and scientific research investment of level-1 indexes were 0.507, 0.267 and 0.226, respectively. Empirical research showed that compared with the original appraisal indexes, the results of the new performance appraisal model were more targeted, enabling the research team to identify setbacks.Conclusions:The indexes set in the model built in this study prove more scientific, objective, and more reasonable in weight assignment. Such indexes can positively motivate and encourage the researchers, promoting the clinical-basic research integration, as well as the disciplinary development and research talent cultivation of the hospital.