Objective:To explore the latent classes of recurrence fear in nasopharyngeal carcinoma patients and analyze their influencing factors.Methods:From July 2021 to December 2023, convenience sampling was used to select nasopharyngeal carcinoma patients admitted to the Eye and ENT Hospital of Fudan University as research subjects. The survey was conducted using the General Information Questionnaire, Fear of Progression Questionnaire-Short Form, Brief Illness Perception Questionnaire, and Medical Coping Modes Questionnaire. Mplus 8.3 software was used for latent profile analysis. Multivariate logistic regression was used to analyze the factors influencing the different classes of recurrence fear in nasopharyngeal carcinoma patients.Results:A total of 208 questionnaires were distributed, and 208 valid questionnaires were collected, with a valid response rate of 100.00%. The recurrence fear score of 208 nasopharyngeal carcinoma patients was (34.01±8.32). The fear of recurrence in nasopharyngeal carcinoma patients included three latent classes: low fear (19.71%, 41/208), moderate fear (66.83%, 139/208), and high fear (13.46%, 28/208). There were statistically significant differences in gender, working condition, individual monthly income, tumor clinical stage, illness perception, and medical coping modes among nasopharyngeal carcinoma patients with different recurrence fear classes ( P<0.05) . Conclusions:Nasopharyngeal carcinoma patients generally have a fear of recurrence. Medical and nursing staff should focus on patients who are female, retired or unemployed, have low personal economic income, have high tumor stages, have severe negative illness perception, and have negative coping modes, and take effective intervention measures as soon as possible.