Objective:To explore the effects of aerobic exercise combined with resistance exercise on cancer-related fatigue and sleep quality in elderly lung cancer patients undergoing chemotherapy after surgery.Methods:From February 2019 to August 2019, this study selected 80 lung cancer patients undergoing chemotherapy after surgery at Affiliated Tumor Hospital of Guangxi Medical University as subjects by convenience sampling. All patients were divided into research group ( n=40) and control group ( n=40) with the method of random number table. Patients of control group received the routine nursing and health education. On the basis of routine nursing, patients of research group carried out the aerobic exercise combined with resistance exercise. The cancer-related fatigue and sleep quality of patients between groups were compared before and after intervention. Results:There were 36 valid questionnaires in research group and 37 in control group. A total of 8 weeks after intervention, scores of affective meaning, behavioral/severity and cognitive/mood in Revised Piper Fatigue Scale (RPFS) , of patients in research group were lower than those in control group with statistical differences ( P<0.05) ; but there was no statistical difference in the score of sensory dimension of patients between two groups ( P>0.05) . The score of sleep quality of patients in research group was lower than that in control group 8 weeks after intervention with a statistical difference ( P<0.05) . Conclusions:The application of aerobic exercise combined with resistance exercise in lung cancer patients undergoing chemotherapy after surgery can effectively alleviate cancer-related fatigue and improve sleep quality of patients which has a value of clinical application and popularization.