1.Influence of hypertension on 5-year all-cause death in patients with acute myocardial infarction with ST segment elevation
Peng HUANG ; Fuchun ZHANG ; Jieming MAO ; Wei GAO
Chinese Journal of Postgraduates of Medicine 2006;0(13):-
Objective To evaluate the factors influencing the 5-year all-cause death in acute myocarclial infarction with ST segment elevation.Methods Five hundred and ten patients(
2.Research on vertical integration of medical resource in Shanghai
Jieming QU ; Weiping LI ; Bo YAN ; Xiaoli CHEN ; Qiuyun GAO ; Tinglan LU ; Jun HU
Chinese Journal of Hospital Administration 2011;27(7):499-502
The article summarized relevant theories and successful practical experience about medical resource integration, analyzed the background of regional medical-trust in Shanghai, and discussed three different model of regional medical-trust building, and their own advantages and disadvantages. Furthermore it discussed the main framework of regional medical-trust pilot reform,including administrative and operational model, insurance-payment model and visiting-doctor model. Then, it introduced the reform strategies of regional medical-trust pilot and present progress.
3.Study on the teaching case database construction of gynecology of Traditional Chinese medicine
Ling ZHU ; Jie GAO ; Jieming HUANG ; Songping LUO ; Limian XU ; Ying ZHAO ; Cheng Zeng ; Huihui LIAO ; Lei ZENG ; Lei CAO
Chinese Journal of Medical Education Research 2014;(9):912-915
The case is the cornerstone of case teaching. The construction of case database can support case teaching and its orderly development. The clinical cases of gynecology of Chinese medicine were collected, sorted and processed in combination with the teaching syllabus and teaching objective. Operating platform was based on the Excelltable. The column was divided into overview, menstrual disorders, leukorrhoeal diseases, pregnancy disease, postpartum disease and miscellaneous diseases of gynecology with hierarchical set of 15 modules per column, including basic information, complaints, history, symptoms, physical examination, diagnosis, application purpose and context and so on. And the corresponding search term was also selected. Cases can be divided into introduction cases and improvement ones according to their easiness and difficulty , into typical cases and atypical ones according to their feature types. Case database content also needs to be constantly revised by teaching activities to make it more suitable for clinical teaching.
4.Investigations on preparation and release behavior in vitro of 9-nitro camptothecin encapsulated micelles.
Jieming GAO ; Jing MING ; Zhongwei GU ; Xingdong ZHANG
Journal of Biomedical Engineering 2008;25(6):1338-1343
9-nitro camptothecin (9-NC) loaded amphiphilic copolymer micelles were prepared with solvent evaporation method. The effects of temperature, distilled water volume, stirring rate, and drug input amount on the size and drug content of micelles were further discussed. As a result, well dispersed spherical micelles with drug content of 4.9 percent and 50 -70 nanometers in diameter were achieved with the following preparation conditions: water bath temperature 60 degrees C , distilled water amount 16 ml, stirring rate 6 500 r/min, and drug input amount 1.2 mg. 9-NC release profiles in vitro illustrated that drug release from micelles included initial burst release and following controlled release. The release rate was decreased with the increase of drug content.
Antineoplastic Agents
;
administration & dosage
;
chemistry
;
Camptothecin
;
administration & dosage
;
analogs & derivatives
;
chemistry
;
Delayed-Action Preparations
;
chemical synthesis
;
chemistry
;
Drug Carriers
;
chemistry
;
Drug Compounding
;
Humans
;
Micelles
;
Nanoparticles
;
Particle Size
;
Polymers
;
Solubility
5.Positive rates and influencing factors of depression and anxiety among managed diabetic patients in community
Xiangyu CHEN ; Jieming ZHONG ; Lihua GUO ; Ming ZHAO ; Chunxiao XU ; Feng LU ; Hui LI ; Xin GAO ; Le FANG
Journal of Preventive Medicine 2019;31(7):683-687
Objective :
To explore the positive rates and influencing factors of depression and anxiety among managed diabetic patients in community and to provide evidence for the future mental health intervention.
Methods:
Random sampling method was used to select the diabetic patients from the local health information platform in Ningbo. The anxiety and depression symptoms of the diabetic patients were evaluated by 9-Item Patient Health Questionnaire(PHQ-9)and 7-Item Generalized Anxiety Disorder Scale(GAD-7). Logistic regression model was applied to analyzing the influencing factors for anxiety and depression in diabetic patients.
Results:
A total of 1 032 diabetic patients were enrolled,with a response rate of 91.98%. The positive rate of depression was 9.01% and the positive rate of anxiety was 3.78%. The results of multivariate logistic regression analysis showed that divorced/widowed(OR=3.046,95%CI:1.522-6.100),having two comorbidities or more(OR=6.723,95%CI:2.495-18.120)and suffering diabetes for more than ten years(OR=2.668,95%CI:1.406-5.062)were the risk factors for depression in diabetic patients,while having a college education or above(OR=0.288,95%CI:0.093-0.893)was the protective factor for depression in diabetic patients;unmarried(OR=13.244,95%CI:1.268-138.377),having two comorbidities or more(OR=6.979,95%CI:2.164-22.503) and suffering diabetes for more than ten years(OR=3.109,95%CI:1.241-7.787)were the risk factors for anxiety in diabetic patients.
Conclusion
Marital status,the number of comorbidity,course of diabetes and education level could affect the occurrence of depression in diabetic patients;marital status,the number of comorbidity and course of diabetes could affect the occurrence of anxiety in diabetic patients.
6.Effects of kinesio taping on the biomechanical characteristics of the lower limbs during side-step cutting
Jing YOU ; Wenqi HUANG ; Wei ZHENG ; Jieming LU ; Yanhua GUO ; Yuan GAO ; Zheyu XIONG
Chinese Journal of Tissue Engineering Research 2024;28(27):4383-4389
BACKGROUND:Kinesio taping has been widely used as a means of sports protection,but its role as a means to correct abnormal biomechanical changes of the lower limbs during side-step cutting remains unclear. OBJECTIVE:To analyze and compare the changes in lower limb kinematics and dynamics when the subjects complete the side-step cutting of the knee joint under the conditions of kinesio taping,placebo taping and blank control. METHODS:Thirty-nine male college students majoring in basketball were recruited as subjects.Each subject was tested with kinesio taping,placebo taping or no taping.The mechanical correction method was used to patch the dominant knee joint of each subject.The run-up speed of 4.5-5.5 m/s was selected to complete the 45° side-step cutting motion,and the kinematics and kinetics data were collected synchronously by the three-dimensional dynamic capture system and the force measuring platform.The kinematics and kinetics parameters at the moment of initial touchdown and peak ground reaction force were selected for data analysis.SPSS 27.0 software was used for statistical analysis of the test data. RESULTS AND CONCLUSION:Kinematic indexes:compared with no taping and placebo taping,the hip abduction and knee valgus angles at the initial touchdown moment were significantly decreased when kinesio taping was used(P<0.05);at the moment of peak lateral ground reaction force,the angles of hip abduction,knee valgus and ankle plantar flexion decreased significantly(P<0.05),and the knee flexion angle was significantly increased(P<0.05).Kinetic indexes:Compared with no taping,both kinesio taping and placebo taping significantly reduced hip abduction and external rotation torque,knee valgus and external rotation torque at the moment of initial touchdown(P<0.05),and significantly reduced peak vertical ground reaction force and peak horizontal backward ground reaction force(P<0.05);in addition,kinesio taping significantly reduced peak lateral ground reaction force compared with no taping and placebo taping(P<0.05).These results indicate that kinesio taping of the knee joint may improve some kinematic and kinetic indexes associated with lower limb injury risk factors during the completion of the side-step cutting in basketball specialized college students to some extent,and may have a positive effect on the prevention of injury during the side-step cutting.In addition,the trends in the effects of placebo taping and kinesio taping on the knee joint are more consistent in terms of changes in some indexes,suggesting that there may be a placebo effect on the mechanism of action of kinesio taping.
7.Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease.
Jie YU ; Jiangli HAN ; Jieming MAO ; Lijun GUO ; Wei GAO ;
Chinese Medical Journal 2014;127(6):1039-1045
BACKGROUNDMany studies have shown that the serum uric acid (SUA) level is one of the cardiovascular risk factors. The aim of the study is to evaluate the relationship between SUA levels and the severity of coronary artery disease (CAD) assessed by angiography and the Syntax score in patients with obstructive CAD.
METHODSParticipants who visited our hospital for a coronary angiography, from December 2007 to September 2012, were eligible for this analysis. SUA and other blood parameters after at least 12-hour fast were determined. First, the patients were divided into tertiles according to their Syntax scores (low Syntax score group: Syntax score ≤ 10.0; moderate Syntax score group: 10.0
RESULTSA total of 347 patients were registered for the study. The SUA levels in the high Syntax score group were significantly higher than that of the moderate Syntax score group and the low Syntax score group ((392.3 ± 81.6) µmol/L vs. (329.9 ± 71.0) µmol/L, P < 0.001; (392.3 ± 81.6) µmol/L vs. (311.4 ± 64.7) µmol/L, P < 0.001). The SUA level was positively correlated not only with the Syntax score (r = 0.421, P < 0.001; 95% CI: 0.333-0.512), but also with the number of diseased vessels (r = 0.298, P < 0.001; 95% CI: 0.194-0.396). After multiple linear regression analysis, SUA levels were identified to be independently correlated with a high Syntax score (B = 0.033, 95% CI 0.023-0.042, P < 0.001). Compared with the normal SUA subgroup, the high SUA subgroup tended to have a higher Syntax score (19.9 ± 8.7 vs. 13.6 ± 7.5, P < 0.001) and more multi-vessel disease (70.8% vs. 46.6%, P < 0.001). Follow-up data showed a higher incidence of MACE in the high SUA subgroup (20.8% vs. 6.0%, P < 0.001). Binary Logistic regression analysis indicated that the elevated SUA can predict the long-term prognosis of patients with obstructive CAD (OR = 2.968, 95% CI 1.256-7.011, P = 0.013). Kaplan-Meier analysis showed a significantly lower event-free survival rate in patients with high SUA levels than in the normal SUA subgroup (79.2% vs. 94.0%, Log rank = 17.645, P < 0.001).
CONCLUSIONSSUA levels were independently associated with the severity of CAD in patients with obstructive CAD. An elevated SUA is associated with cardiovascular events and may be useful as a biomarker of the severity of CAD.
Aged ; Arterial Occlusive Diseases ; blood ; mortality ; Coronary Artery Disease ; blood ; mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Uric Acid ; blood