Objective To study the application effect of nursing pathway in maternal midwifery in perinatal period.Methods A total of 120 cases were randomly divided into study group and control group according to the random number table method.The control group was treated with routine nursing care, while the study group was treated with nursing pathway intervention.After nursing, the vaginal delivery and cesarean section, and the first, second, third stage of labor and total labor of the two groups were investigated and recorded.After the operation, the postpartum hemorrhage, hospitalization time and hospitalization expenses of the two groups were recorded and analyzed, and the maternal SAS and SDS score were evaluated and analyzed.The pregnancy outcomes of the two groups were recorded.Results he vaginal birth rate was significantly higher than the control group (88.33% vs.66.67%,P<0.05);The first, second stage, third stage of labor and total labor time were shorter than the control group (P<0.05).The hospitalization time of the study group was significantly shorter, the cost of hospitalization was significantly lower, the amount of postpartum hemorrhage was significantly less than that of the control group (P<0.05).After nursing, SAS and SDS scores of two groups were significantly lower than nursing before, and the study group was significantly lower than the control group (P<0.05);Maternal urinary retention, postpartum hemorrhage and the incidence of adverse outcomes of perineal incision in the study group of were significantly lower than he control group, neonatal fetal distress and the incidence of neonatal asphyxia was significantly lower than the control group;the Apgar score was significantly lower than the control group;differences in the two groups were statistically significant(P<0.05).Conclusion Pathway nursing measures in the perinatal period can significantly improve the outcome of pregnancy;and it is worthy of popularization.

Objective To study the application effect of nursing pathway in maternal midwifery in perinatal period.Methods A total of 120 cases were randomly divided into study group and control group according to the random number table method.The control group was treated with routine nursing care, while the study group was treated with nursing pathway intervention.After nursing, the vaginal delivery and cesarean section, and the first, second, third stage of labor and total labor of the two groups were investigated and recorded.After the operation, the postpartum hemorrhage, hospitalization time and hospitalization expenses of the two groups were recorded and analyzed, and the maternal SAS and SDS score were evaluated and analyzed.The pregnancy outcomes of the two groups were recorded.Results he vaginal birth rate was significantly higher than the control group (88.33% vs.66.67%,P<0.05);The first, second stage, third stage of labor and total labor time were shorter than the control group (P<0.05).The hospitalization time of the study group was significantly shorter, the cost of hospitalization was significantly lower, the amount of postpartum hemorrhage was significantly less than that of the control group (P<0.05).After nursing, SAS and SDS scores of two groups were significantly lower than nursing before, and the study group was significantly lower than the control group (P<0.05);Maternal urinary retention, postpartum hemorrhage and the incidence of adverse outcomes of perineal incision in the study group of were significantly lower than he control group, neonatal fetal distress and the incidence of neonatal asphyxia was significantly lower than the control group;the Apgar score was significantly lower than the control group;differences in the two groups were statistically significant(P<0.05).Conclusion Pathway nursing measures in the perinatal period can significantly improve the outcome of pregnancy;and it is worthy of popularization.

OBJECTIVETo evaluate the efficacy of sequential enteral nutrition support in patients with severe cerebral stroke.

METHODSForty-nine patients with severe cerebral stroke met the inclusion criteria were randomly divided into sequential enteral nutrition group (Group A, n=24) and conventional enteral nutrition group (Group B, n=25). Patients in Group A received short-peptide-based enteral nutrition support first, then gradually transferred to intact protein enteral nutrition. Meanwhile, patients in Group B constantly received intact protein enteral nutrition support. The nutritional indexes and the rate of complications were compared between two groups.

RESULTSThe nutritional indexes were decreased in both groups within 4 weeks after admission, but the decreasing levels of hemoglobin and albumin in Group A were significantly lower than those in Group B (P<0.05), and the incidence of infections and gastrointestinal hemorrhage in Group A was also lower than that in Group B (P<0.05). However, there were no significant differences in body weight, BMI, triceps skinfold thickness, biceps circumference, arm muscle circumference between two groups (P>0.05).

CONCLUSIONSequential enteral nutritional support can improve the nutritional status and decrease the incidence of complications in critical patients with cerebral stroke.

Aged ; Aged, 80 and over ; Enteral Nutrition ; methods ; Female ; Humans ; Male ; Middle Aged ; Stroke ; therapy

Objective To evaluate the value of color Doppler two-dimensional ultrasound combined with real-time ultrasonic shear wave elastography (SWE) in the early diagnosis of breast cancer.Methods A total of 110 suspected breast tumor patients from October 2015 to April 2017 were selected as subjects.Comprehensive detailed examinations on the patients were conducted by routine two-dimensional ultrasound,color Doppler and SWE,and the lesion location,size,boundary,capsule,internal echo,blood flow,elastic value and other related data were recorded.The BI-RADS classification was conducted based on these data.Pathological diagnosis was used as the gold standard to compare the diagnostic effects of color Doppler two-dimensional ultrasound and the combination of color Doppler two-dimensional ultrasound and SWE.Results Of the 110 patients,78 were malignant and 32 were benign.The sensitivity of color Doppler two-dimensional ultrasound for breast cancer diagnosis was 83.3％,the specificity was 81.2％,and the accuracy was 82.7％.The sensitivity of color Doppler two-dimensional ultrasound combined with SWE for breast cancer diagnosis was 88.5％,the specificity was 90.6％,and the accuracy was 94.5％.Conclusion Color Doppler two-dimensional ultrasound combined with SWE can complement each other and improve the qualitative and quantitative diagnosis of early breast cancer.

AIM: To probe into the anti-epilepsy action of artificial Calculus Bovis,by observing its effect on the behavioral of the experimental epileptic rats,neuron loss in the hippocampus and hilus,and GAD positive cell alteration in the hippocampus.METHODS: SD rats were divided into three groups: group A(artificial Calculus Bovis treatment group);group B(acute epilepsy group) and group C(control group).A model of acute epilepsy rats was established by PTZ.The rat's behavioral alteration was observed by the Racine' scale.The neurons in the hippocampus and hilus were calculated by Nissl staining.The GAD positive cells were observed by immunohistochemical staining.RESULTS: The latency of the first seizure in group A was longer than that in group B,while the seizure times in group A was less than that in group B.Besides,in group A,both the neuron loss amount in the hippocampus and hilus and the GAD positive cell loss amount in the hippocampus were less than those in group B.CONCLUSION: The artificial Calculus Bovis prolonged the latency of the first seizure time,decreased the frequency of seizure,and prevented the neuron loss and protected the GAD positive cells.

Background: This study aims to investigate the effect of integrin β1 on wound healing induced by adipose-derived stem cells (ADSCs), as well as the corresponding mechanism. Methods: Integrin β1 was overexpressed in ADSCs. Thereafter, flow cytometry and transwell chambers technology were used to measure the endothelial-like differentiation (CD31 as a biomarker of endothelial cell) and cell migration, respectively. Western blot was used to detect the activation of PI3K/AKT, NF-κB and ERK signaling pathways. The effects of integrin β1 overexpression on healing time, healing rate and fibroblast number were further evaluated in the rat models of chronic refractory wound. Results: The overexpression of integrin β1 increased CD31+ endothelial-like cells (about 3.6-fold), promoted cell migration (about 1.9-fold) and enhanced the activation of PI3K (p-PI3K; about 2.1-fold) and AKT (p-AKT; about 2.2-fold). These effects were all weakened when PI3K/AKT pathway was inhibited by LY294002 treatment. In addition, the experiments in rat wound models showed that integrin β1 overexpression obviously shortened healing time (approximately 0.41-fold), increased healing rate (about 2.7-fold, 2.8-fold and 1.6-fold at day 7, 14 and 21) and increased the number of fibroblasts (approximately 3.1-fold at day 21). All of the above differences were statistically significant (p < 0.05). Conclusion Integrin β1 can promote the migration and endothelial-like differentiation of ADSCs by activating PI3K/AKT pathway and then enhance the function of ADSCs in promoting wound healing.

To investigate the effects of neuronal histamine on spatial memory acquisition impairment in rats with pentylenetetrazole-kindling epilepsy, and to explore its mechanisms.A subconvulsive dose of pentylenetetrazole (35 mg/kg) was intraperitoneally injected in rats every 48 h to induce chemical kindling until fully kindled. Morris water maze was used to measure the spatial memory acquisition of the rats one week after fully pentylenetetrazole-kindled, and the histamine contents in different brain areas were measured spectrofluorometrically. Different dosages of hitidine (the precursor of histamine), pyrilamine (H1 receptor antagonist), and zolantidine (H2 receptor antagonist) were intraperitoneally injected, and their effects on spatial memory acquisition of the rats were observed.Compared with control group, escape latencies were significantly prolonged on Morris water maze training day 2 and day 3 in pentylenetetrazole-kindling epilepsy rats (all<0.05); and the histamine contents in hippocampus, thalamus and hypothalamus were decreased significantly (all<0.05). Escape latencies were markedly shortened on day 3 by intraperitoneally injected with histidine 500 mg/kg, and on day 2 and day 3 by intraperitoneally injected with histidine 1000 mg/kg in pentylenetetrazole-kindling epilepsy rats (all<0.05). The protection of histidine was reversed by zolantidine (10 and 20 mg/kg), but not by pyrilamine.Neuronal histamine can improve the spatial memory acquisition impairment in rats with pentylenetetrazole-kindling epilepsy, and the activation of H2 receptors is possibly involved in the protective effects of histamine.
Animals ; Benzothiazoles ; pharmacology ; Brain Chemistry ; drug effects ; Epilepsy ; chemically induced ; complications ; Hippocampus ; chemistry ; Histamine H1 Antagonists ; pharmacology ; Histamine H2 Antagonists ; pharmacology ; Histidine ; pharmacology ; Hypothalamus ; chemistry ; Kindling, Neurologic ; physiology ; Memory Disorders ; drug therapy ; etiology ; Pentylenetetrazole ; Phenoxypropanolamines ; pharmacology ; Piperidines ; pharmacology ; Pyrilamine ; pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Histamine H2 ; drug effects ; physiology ; Spatial Memory ; drug effects ; Spectrometry, Fluorescence ; Thalamus ; chemistry