1.Expression of cyclin B_1 in human ameloblastoma
Zhong MING ; Zhang YING ; Wang JIE
Journal of Practical Stomatology 1995;0(04):-
Objective:To detect the expression of cyclin B 1 in human ameloblastoma(AB). Methods:Expression of cyclin B1 was detected in 73 cases of AB (32 primary, 33 recurrent and 8 malignant cases), 19 of odontogenic keratocyst (OKC) and 7 of normal oral mucosa by streptovidin-biotin method. Results:The ratio of positive nuclear expression of cyclin B 1 in normal oral mucosa, OKC and AB was 28.6%(2/7), 36.8%(7/19) and 63.0%(46/73) respectively (P
2.Analysis of 3 cases with nephrotic damage by anti-neutrophil-cytoplasmic antibodies associated vasculitis in children.
Ying-jie LI ; Yan GAO ; Hong YE ; Fu ZHONG
Chinese Journal of Pediatrics 2004;42(6):458-459
Antibodies, Antineutrophil Cytoplasmic
;
blood
;
Child
;
Female
;
Hematuria
;
etiology
;
Humans
;
Kidney
;
pathology
;
physiopathology
;
Kidney Function Tests
;
Proteinuria
;
etiology
;
Renal Insufficiency
;
etiology
;
Vasculitis
;
blood
;
complications
;
pathology
5.Module-based analysis: deciphering pathological and pharmacological mechanisms of complex diseases and multi-target drugs.
Yin-ying CHEN ; Li-peng FENG ; Yong LI ; Ping WU ; Zhong WANG ; Jie WANG
China Journal of Chinese Materia Medica 2015;40(20):4112-4116
A complex disease is rarely a consequence of abnormality in a single gene. It is known that many drugs exhibit a therapeutic effect by acting on multiple targets, produce synergies to intervene the occurrence and development of diseases. Unlike the traditional methods which act on single molecule or pathway, this disease-drug target network constructed with high throughput data vividly showed the complex relationship between drugs, their targets and diseases. However, the networks are usually extremely complex. In order to reduce the complexity, it is necessary to deconstruct the network and identify module structures. In this study, framework of module analysis was summarized from four aspects: module concept, structure and identification methods, importance of disease-drug module identification, and its application. Module-based analysis provides a new perspective for deciphering the drug intervention mechanisms for complex diseases, and provides new ideas and pathways to reveal the mechanisms of multi-target and multi-component drugs.
Drug Delivery Systems
;
Drugs, Chinese Herbal
;
administration & dosage
;
chemistry
;
Gene Regulatory Networks
;
drug effects
;
Humans
;
Molecular Targeted Therapy
7.A comparative study of the diagnostic value of endoscopic ultrasonography with pathological features of upper gastrointestinal mesenchymal tumors
Bin CHENG ; Li ZHONG ; Fang DING ; Huaping XIE ; Ying WANG ; Yuzhen YANG ; Mei LIU ; Jie WAN
Chinese Journal of Internal Medicine 2009;48(9):724-728
ostic sensitivity and specificity of EUS are high in distinguishing benign and malignant character of upper digestive tract GIMTs. EUS plays an important role in guiding the clinical management of upper digestive tract GIMTs.
8.Efficacy of abdominal and transanal lavage-suction drainage system for early anastomotic leakage after neoadjuvant chemoradiotherapy and surgery for rectal cancer.
Sheng Hui HUANG ; Pan CHI ; Ying HUANG ; Xiao Jie WANG ; Wei Zhong JIANG
Chinese Journal of Gastrointestinal Surgery 2022;25(8):734-737
9.Prevention measures and reasons analysis of the elder patients early anti-dislocation after total hip arthroplasty
Minling LI ; Ying ZHONG ; Jie NI ; Xiaoling CHEN ; Qiaoli LIU ; Zizhen GUI ; Tianwen HUANG ; Yan KANG
Modern Clinical Nursing 2016;15(7):27-30
Objective To explore the reasons and preventive measures of early dislocation after total hip arthroplasty in elder patients. Method A retrospective study was done to analyze dislocation time, reason and time of 168 elderly patients with early anti-dislocation after total hip arthroplasty in joint surgery. Results Only 7 patients (4.1%) had type I joint dislocation, including 2 male and 5 female patients aged 65~89 years. The dislocation happened in 4~5 weeks postoperatively, mainly resulting from hip joint over flexion when urinating in bed, sleep-turning, loaded-moving, walking and stoop and diachoresis. Conclusions For the elderly patients after total hip replacement, it is type I dislocation which happened 4 ~ 5 weeks after operation, more femal than male, reasons including over-exercrse. Effective prevention measures includes regular rehabilitation training, early precautions enhanced mental support and safety nursing.
10.The Process of Mesenchymal Stem Cells and their Potential as Cardiac Therapeutics
Shu-Kuan LING ; Ying-Hui LI ; Zhong-Quan DAI ; Fen YANG ; Jie-Lin NIE ;
China Biotechnology 2006;0(06):-
Bone marrow mesenchymal stem cells (MSCs), multipotent stem cells, can replicate as undifferentiated cells and have the potential to differentiate into different lineages of mesenchymal tissues, including bone, cartilage,endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells. The ischemia-induced death of cardiomyocytes results in scar formation and reduced contractility of the ventricle. Several preclinical and clinical studies have supported the notion that MSCs therapy may be used for cardiac regeneration.When transplanted into the infracted heart, MSCs prevent deleterious remodeling and improve recovery, but the mechanism is not clear. In this work,we review evidence and new prospects that support the use of MSCs in cardiomyoplasty.