Adolescent ; Humans ; Lung ; diagnostic imaging ; pathology ; Lung Neoplasms ; diagnostic imaging ; pathology ; surgery ; Male ; Papilloma ; diagnostic imaging ; pathology ; surgery ; Pneumonectomy ; methods ; Tomography, X-Ray Computed

Objective To observe the efficacy of methylprednisolone stosstherapy of the IgA nephropathy complicated with partial crescenties formation and effects of this therapy on the urine protein output and renal function.Methods 93 patients of IgA nephropathy complicated with partial crescenties formation were identified by renal biopsy and diagnosed according to the WHO diagnostic criteria in 1982 formulation.The patients were randomly divided into two groups:the control and the treating groups.The control group was treated with oral prednisolone (1mg/Kg/day) plus oral cyclophosphamide(2mg?kg -1 ?d -1 ),while the treating group was administered, on the basis of the therapeutic scheme of the control group,with methylprednisolone 0 5～1 0g(20mg?Kg -1 ?d -1 ) in normal saline solution intravenously by drip,for 8 weeks,The degree of puffiness,BP and 24h urine volume were observed in both groups befoue and after the treatment. The 24h urine protein quantitative determination,urine RBC count(uRBC),urine creatinine,blood creatinine(Cr),blood urea nitrogen(BUN),serum albumin (ALB) and the endogenous creatinine clearance rate (Ccr) were also tested.The side effects in two groups were observed at the same time.Results The urine protein output amounts, urine RBC count,blood Cr and BUN were significantly decreased (P

Henoch-Sch?nlein purpura ( HSP ) is the most common disease with small vasculitis as the main pathological changes in childhood. Gastrointestinal symptoms as the main clinical manifestations are called abdominal type allergic purpura,some children show abdominal symptoms before skin purpura,even without skin purpura during the whole course of disease,which usually leads to misdiagnose. This article summaries the clini-cal diagnosis and treatment progress of abdominal type allergic purpura.

Objective To analyse the differences between idiopathic and symptomatic childhood epilepsy with occipital patoxysms. Methods The medical records of 38 patients with interictal spikes and/or sharp waves over occipital areas,posterior temporal-parietal areas,or both were retrospectively analysed.Epidemiological data,ictal symptoms,electroencephalogram,neuroimaging studies,treatment response and prognosis were compared using chi-square test or Mann-Whitney U test. Results Four patients of idiopathic group had positive family history related to nervous system.Seizures were more frequent in symptomatic group than in idiopathic group.Both groups showed autonomic symptoms,while ictal vomiting and deviation of eyes were more common in the presence of Panayiotopoulos type.The prognosis of idiopathic group was much better than that of symptomatic group. Conclusion Panayiotopoulos syndrome is more common.Neurologic deficits and electroencephalographic characteristics are major factors to predict seizure remission in children with occipital lobe epilepsy.Idiopathic childhood epilepsy with occipital paroxysms may result in better prognosis.

Objective:Heart rate variability (HRV) contains a lot of information concerning the cardiovascular regulation,and can be an important indicator,quantitatively reflecting of autonomic nervous function and the normal heart activity,also can play an important role in cardiovascular regulation.Therefore,HRV signals are analyzed using common HRV analysis methods.Methods:Decompose HRV signals of congestive heart failure and normal persons into 6 scales using Multi-resolution analysis.The wavelet coefficient energy is calculated,especially the frequency energy of cd3 to cd6.Results:Energy is mainly concerned in the lower band of high frequency band and low frequency band,where the energy differences between the two groups are more evidence.It's more precise compared to the result with frequency-domain analysis.Conclusions:To gain results with universal law,more different analysis methods need to be improved and lots of researches are necessary.

Aim Background tumor necrosis factor-alpha (TNF-?) is produced by monocyte-macrophages and adipocytes. It may provide the link between inflammation and atherosclerosis. The aim of this study was to evaluate the effect of fenofibrate on serum TNF-? concentration and TNF-? secretion by adipocytes from hypercholesterolemia rabbits.Methods Ten male New Zealand white rabbits were fed with high-cholesterol diet for 8 weeks, and were randomly divided into two groups: ①high cholesterol group: maintained cholesterol diet for 4 wks; ② fenofibrate group: the same cholesterol diet supplemented with fenofibrate (30 mg?kg?d -1) for 4 weeks. And control group was fed with normal diet for 12 weeks. Subcutaneous adipose was collected for adipocytes culture. TNF-? concentrations in serum and adipocytes culture supernatant were measured by ELISA. Adipocytes were harvested for semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) studies. Results :Rabbits fed with high-cholesterol diet showed higher serum levels of total cholesterol, low density lipoprotein cholesterol than those fed with normal diet (P

Objective To comprehend the etiology and the clinical characteristics of hypereosinophilia.Methods The clinical data of 53 patients with hypereosinophilia admitted to Peking Union Medical College Hospital from November 1992 to February 2005 were analyzed.Results The causes of reactive hypereosinophilia included allergic diseases,infections,connective tissue diseases,malignant diseases,lung diseases,eosinophilic gastroenteritis.idiopathic hypereosinophilic syndrome had longer course of disease;more organ involved than reactive causes.The incidence of lymph node enlargement,spleen enlargement and thrombus was higher than the reactive.IHES had higher level of white blood cell count,absolute eosinophilic count,IgG and CRP.Conclusion The etiology and clinical characteristics of hypereosinophilia are various,so the differential diagnosis of hypereosinophilia is very important.

In order to evaluate appropriately the role of lipid metabolism by the refined konjac meal (RKM), a new source of dietary fiber, the effects of RKM on the level of serum and liver lipids, hepatic histopathology and on the composition and output of fecal bile acids in comparison with pectin, algin and agar were studied.The RKM contained about 75-80% of glucomannan. All four kinds of dietary fiber "were given at a level of 5% in the diet to the young male Wistar rats fed on a lipid-rich diet containing 5% lard, 1% cholesterol and 0.25% chplate. The control group was fed on a lipid-rich diet alone withput fiber. The normal group was fed on a basal diet without extra lipid added. Feeding period was 9 weeks.The results obtained were as follows;1)All the dietary fibers tested have the similar effects on serum lipid composition. At the end of 2-week of the experiment, the serum total cholesterol levels of the four experimental groups were only 62% to 75% of that of the control group, and at the end of 7-week they were lowered to the same level of the normal group. The level of the triglyceride in serum did not change in all groups during the experiment.2)Relative liver weights were lower in four experimental groups than in control group. Hepatic hisiopathological examinations showed lipotropic effect in RKM, pectin and algin groups. Both of the above effects appeared most significantly in RKM group. The concentrations of total cholesterol and triglyceride in liver in RKM group were lower than those in control group as well as other three experimental groups.3)No harmful effects on the intake of food and growing of rats were found when feeding these four kinds of dietary fiber at the level of 5%.4)The daily output of fecal bile acids (CDCA + GDCA) was significantly increased in four experimental groups.The increase of fecal output of bile acids, especially CDCA, may be one of the mechanisms of hypocholesterola-emic effect of dietary fibers.It could be concluded that RKM has the same significant hypocholestero-lemic effect as the pectin, algin and agar, but its lipotropic effect is more potent.

Disrupted pancreatic β-cell function and decreased β-cell number are two of the main causes of type 2 diabetes mellitus. Recent studies have indicated that autophagy plays an important role in protecting pancreatic β-cell and in maintaining the structure, number, and secretive function of pancreatic β-cell. Although autophagy has been a focus of study in recent years, including areas such as tumor, neural diseases and aging, but its relationship with pancreatic β-cell was not included. In this paper we review the concept of autophagy and its role in maintaining the normal function of pancreatic β-cells.

Objective To investigate the expression and clinical significance of Bmi-1,Podoplanin and p53 in human thymic epithelial tumor(TET) according to new histological classification of World Health Organization. Methods One hundred and ten TET tissue chips were prepared,and the expressions of Bmi-1,Podoplanin and p53 were detected by NovoLinkTM Polymer detection systems. Results The positive expressions of Bmi-1,Podoplanin and p53 were 68.2%,41.8% and 42.7%,respectively.The positive expressions of Bmi-1,Podoplanin and p53 were significantly associated with pathologic histological classification,Masaoka staging and clinic pathological grading(P