The clinical manifestation included snoring and mouth breathing for 2 years, repeated coughing and shortness of breath in action for more than 1 year. Physical examination of oral cavity showed tonsils were in grade III. The endoscopy showed 2/3 of postnaris were blocked by the adenoids. The preoperative ultrasonic cardiogram revealed the right atrial and right ventricular dilatation, pulmonary artery widened. The preoperative polysomnography (PSG) showed apnea-hypopnea index (AHI) was 28.5 events an hour, and the lowest oxygen saturation (LSaO2) was 39%. The patient was diagnosed as severe obstructive sleep apnea hypopnea syndrome with pulmonary hypertension. The postoperative PSG showed the AHI was 11.7 events an hour, and the LSaO2 was 86%. The ultrasonic cardiogram at 5 months after surgery didn't show any abnormalities.
Adenoids ; pathology ; Child ; Cough ; Humans ; Hypertension, Pulmonary ; complications ; diagnosis ; Palatine Tonsil ; pathology ; Polysomnography ; Sleep Apnea, Obstructive ; complications ; diagnosis ; Snoring

Primary cutaneous lymphomas are a group of non-Hodgkin's lymphomas originating from the skin, with unique clinical and histological features. In December 2023, the National Comprehensive Cancer Network (NCCN) updated and released the Clinical Practice Guidelines for Primary Cutaneous Lymphomas (Version 1. 2024). Compared to the 2023 edition of the Guidelines, this update mainly focuses on the principles of diagnostic assessment, staging criteria, treatment principles for mycosis fungoides(MF) at different stages, and recommendations for radiotherapy. In conjunction with the current situation and characteristics of the diagnosis and treatment of primary cutaneous lymphoma in our country, this article interprets the main recommendations of the Guidelines to promote the application of clinical practices in our country.

4-Hydroxycoumarins ; poisoning ; Child ; Female ; Humans ; Lower Extremity ; blood supply ; Thrombosis ; etiology

Objective To investigate the signal transduction of bFGF to regulate the colorectal carci- noma cell growth via PI3K/PKB pathway.Methods MTT assay was used to determine the suppressive effect of bFGF on the growth rate of LoVo cell;(?-~(32)P)ATP incorporation assay was used to detect the increased activity of PKB in LoVo cell;the RT-PCR technique was used to test the expression of cyclin A;Western Blot analysis was used to detect the expressions of PKB and cyclin A protein.Results When the bFGF worked on the LoVo cell at various times,it was found that the PKB activity of the LoVo cell was increased by the(?-~(32)P) ATP incorporation assay.By preprocessing by the depressor-LY294002 and bFGF,the activity of PKB was sig- nificantly reduced(P

Objective To investigate the correlation and clinical significance between CTGF of fibrosis marker and coronary heart disease .Methods Totally 102 cases of coronary heart disease patients by coronary artery angiography ensured were used as coronary heart disease group ,98 cases with age and sex strict matching of coronary heart disease were normal and were used as con-trol group;T test was used to analysis the difference with disease group and control group at base clinical data ,serum CTGF and TGF-β1 ,the correlation between coronary heart disease and serum CTGF level was evaluated by logistic regression analysis ,and clinical diagnosed value was evaluated .Results Triglyceride ,total cholesterol ,apolipoprotein A1 ,high density lipoprotein ,lipopro-tein alpha ,low density lipoprotein ,TGF-β1 and CTGF in coronary heart disease group were significantly higher than those in control group(P<0 .05) .Spearman correlation analysis showed that CTGF and TGF-β1 were positively correlated (r=0 .773 ,P=0 .002) . Serum CTGF can play positive role in the evaluation of the risk stratification of coronary heart disease .Conclusion Age ,smoking , hypertension ,total cholesterol ,apolipoprotein A1 ,high density lipoprotein ,low density lipoprotein ,lipoprotein alpha ,CTGF and TGF-β1 were influencing factors for coronary heart disease .Detection of CTGF in clinical work can be used as assessment coronary artery stenosis and severity index .

Objective To design a fast method based on wavelet analysis for fMRI data. Methods Lifting wavelet decomposition instead of stationary wavelet decomposition was utilized to separate paradigm responsive signal and confound ones in fMRI data, while frequency analysis was used to find out the wavelet scales in which paradigm responsive signal existed, then reconstructed signal from these scales was subjected to correlation analysis for actived pixels. Results Analyzing visual fMRI data revealed that when the significant level was α＜10-6, the proposed method gave more sensitive results than correlation analysis, but process time decreased on a large scale compared with the one based on the stationary wavelet transform. At the mean time, the proposed method only used 24 timepoints of data for wavelet reconstruction while one based on stationary wavelet transform used 256 timepoints of data. Conclusion The proposed method is the fast one based on wavelet transform for analyzing fMRI data, which also gives an effective technique for compressing fMRI data.

Objective To investigate the impaction of different prostate biopsy strategies on the tumor detection.Methods 214 consecutive men who were highly suspected as prostate cancer were included in this study.TRUS guided prostate biopsy of 13 cores was conducted in each patient.Among these individuals,PSA(total prostate specific antigen) level were among 0.8 ng/ml and 112.3 ng/ml,mean 18.7 ng/ml,of which 203 cases were over 4.0 ng/ml.The prostate volume was between 12.3 ml and 182.5 ml with 61.3 ml of mean.DRE(digital rectal examination) was normal in 173 cases and abnormal in 41 cases.The tumor detection rate for each biopsy core was calculated.The sensitivity of different combinations of biopsy cores(eg.prostate biopsy strategies) was compared with a 13 core biopsy protocol,in which besides the sextant biopsies,the far lateral and mid regions of the gland were also taken,as 8 core and 10 core biopsy.Results Prostate cancers were detected in 77 of 214(36.0%) patients with 13 core biopsy protocol.Of the possible combinations of biopsy cores,10-core biopsy protocol that included cores at the base,mid gland and apex of the prostate with lateral base and mid cores detected 97.4% of cancers.The detection rate of this 10-core biopsy protocol was equivalent to that of the 13 core regional biopsy(P=0.5).Conclusions 10-core biopsy protocol that combines cores at the base,mid gland and apex of the prostate with lateral base and mid cores should be the preferred strategy in early detection of prostate cancer.

Objective To investigate the manifestations and genetic mechanisms of male sex reversal syndrome. Methods A 22 year old male patient with 46,XX karyotype was systemically examined and a Y specific sequence tagged site (STS),sY14,was chosen to detect sex determining region of Y (SRY) gene by polymerase chain reaction (PCR). Results This patient shows primary and secondary male sex characters while gonads are hypoplastic and malfunctional.The patent has 46,XX karyotype and SRY gene.Therefore,the patient is diagnosed as 46,XX male sex reversal syndrome. Conclusions Translocation of SRY can bring about 46,XX male sex reversal syndrome,whereas gonads of the patients are hypoplastic and malfunctional because of the absence of other genes on Y chromosome.SRY gene plays an important role in sex determination.

CD4 Antigens ; immunology ; Humans ; Interleukin-2 Receptor alpha Subunit ; immunology ; T-Lymphocyte Subsets ; immunology ; physiology ; T-Lymphocytes, Regulatory ; physiology

Through the research and practice of computer basic course at medical colleges, the paper summarizes the experience of using modern technical means, to reform the traditional teaching ideas, teaching methods, teaching means and teaching management, to diversify teaching resources sharing. It also analyzes the shortcomings and makes recommendations to further strengthen the course development.