Clinical Medicine ; Humans ; Infant ; Prospective Studies ; Triazines ; adverse effects ; Urolithiasis ; chemically induced

Objective:To control the maintenance cost of medical equipment and improve the efficiency and service level for maintenance, and to research the management about classification maintenance for medical equipment based on analytic hierarchy process (AHP).Methods: 69 clinical department and 14 engineers were involved in the questionnaire survey and the evaluated factors were obtained from their questionnaires. The (AHP) was used to determine what is the factor weight of maintenance for the medical equipment, and then calculate the maintenance scores of the equipment. Finally, the weight scores were applied to ABC classification method and the equipments will be divided into three types (A\B\C) as this method, and they will be managed by different mode.Results: Depended on the sixth order analysis data from 6 factors of evaluation (price, frequency, stability, running time, standby factor and difficulty of maintenance) that were compared between any two factors by using AHP, through comprehensive scores ratio to got A\B\C classification and work out relative implement countermeasure of maintenance. The new classification management mode has achieved planning and preventive maintenance for key equipment, regular maintenance for major equipment, and maintenance after event for general equipment. After the method was applied, the fault rate of second half of 2016 year was decrease 30% compared with same time of 2015 year. The total cost of maintenance of 2016 year decreased 10% compared with that of 2015 year. And the satisfaction of clinical department for department of equipment was enhanced.Conclusion: The AHP is applied to classified manage medical equipment and maintain them as weight of factor. This method has resolved many problems on maintenance of equipment, such as confused primary and secondary, and formalism and so on. According to the factor weight of maintenance to manage medical equipment at classification mode, hospital can catch key point of maintenance of equipment, and the maintenance cost can be efficiently controlled, and the work efficiency and clinical service level of equipment department can be improved and enhanced.

Animals ; Autophagy ; Coronaviridae ; genetics ; pathogenicity ; physiology ; Coronaviridae Infections ; physiopathology ; virology ; Humans ; Virus Replication

Objective: To investigate the safety and effectiveness of transvenous embolization of cavernous sinus dural arteriovenous fistula with Onxy or in combination with detachable coils. Methods: Twelve patients with cavernous sinus dural arteriovenous fistula treated by transvenous embolization from February 2007 to December 2010 were analyzed retrospectively. Ten patients were treated via the inferior petrosal sinus approach, 2 were treated via the vein-superior ophthalmic vein approach. Eight patients used Onyx alone, and 4 used Onxy in combination with detachable coils. Results: Circled digit oneAngiography showed complete occlusion in 10 patients immediately after treatment, small amount of residues remained in 2 patients. Six patients were cured with Onyx embolization alone, 2 were improved, 2 were cured with Onyx in combination with detachable coils embolization, and 2 were improved. The total effective rate was 100%, the total cure rate was 66.7%, and none of the patients worsened or died. Circled digit twoTwo patients had intraoperative bradycardia, 3 had postoperative orbital ache. Circled digit threeAll patients received clinical follow-up for 6 to 32 months and no recurrent and worsened were found. Conclusion: The clinical efficacy of transvenous embolization of cavernous sinus dural arteriovenous fistula with Onxy or in combination with detachable coils is effective and safe.

BACKGROUND:Studies have shown that there is a certain correlation between blood lipid levels and bone mineral density in postmenopausal women, but their correlation in men is an open question, which has been less reported. OBJECTIVE:To investigate the relationship between blood lipid levels and bone mineral density in Han and Uygur men with hypertension in Urumqi of Xinjiang Uygur Autonomous Region, as wel as correlation of blood lipid levels with osteoporosis and osteopenia and difference between ethnics. METHODS: A total of 193 male patients with hypertension were categorized into Uygur (n=73) and Han (n=120) groups. Each group was subdivided into osteoporosis or osteopenia group and non-osteoporosis group. Bone mineral density and blood lipid level were analyzed and compared between groups. The correlation between osteoporosis and risk factors was analyzed using logistic regression method. RESULTS AND CONCLUSION:In Uygur hypertension men with osteoporosis or osteopenia, total cholesterol level was positively correlated with the bone mineral density of the femoral neck (r=0.43,P=0.01) and Ward's area (r=0.42, P=0.01); while there were no relationships between blood lipid levels and bone mineral density in Han hypertension men. When a Logistic regression analysis was performed, only total cholesterol level was found to be associated with the presence of osteoporosis or osteopenia after adjustment for body mass index, age and ethnics (OR=1.48,P=0.03). The blood lipid level is associated with bone mineral density in Han and Uygur men with hypertension from Urumqi of Xinjiang Uygur Autonomous Region, which can affect the presence of osteoporosis.

BACKGROUND:Some studies have demonstrated that there is a clear correlation between osteocyte differentiation and leptin. Animal experiments have also confirmed that leptin indirectly inhibits the formation of osteoblasts through the central nervous system, but it also has some influences on the anabolism in bone microenvironment of osteoblasts. OBJECTIVE:To analyze the variation of serum leptin levels in older female patients with osteopenia, and the relationship between serum leptin levels, bone mineral density and related biochemical indexes of bone turnover. METHODS: The older female patients, aged≥ 60 years, who had lived in Xinjiang Uygur Autonomous Region for more than 30 years, were selected. Among these patients, 74 had osteoporosis, 111 had osteopenia, and 191 had normal bone mass. Serum leptin levels, bone alkaline phosphatase and other indicators of the patients were detected using enzyme-linked immunoassay method. RESULTS AND CONCLUSION:Compared with the normal group, the body mass index value and leptin level were significantly lower in the osteoporosis group (P < 0.01) and in the osteopenia group (P < 0.05). The bone mineral densities of al parts of patients in the osteoporosis group were lower than those in the osteopenia and normal groups (P < 0.01), and the bone mineral density value of patients in the ostopenia group was significantly lower than that in the normal group (P < 0.01). The serum leptin levels of older female patients with osteoporosis were significantly positively correlated with the bone mineral density value of the anteroposterior lumbar spine and the left hip bone (r=0.870,r=0.468,P < 0.01). The serum leptin levels of older female patients with osteopenia were significantly positively correlated with the bone mineral density value of the anteroposterior lumbar spine and the left hip (r=0.477, r=0.467,P < 0.01). The serum leptin levels of older female patients with osteoporosis were significantly positively correlated with body mass index (r=0.502,P < 0.01). These results suggest that reduced levels of serum leptin may play an important role in the pathogenesis of osteoporosis and osteopenia in older female patients in Xinjiang Uygur Autonomous Region, China.

Objective To analysis the impact of ? blocker therapy on symptoms of benign prostatic hyperplasia(BPH). Methods 148 cases of BPH patients had been treated with ? blocker for 4 weeks. Symptom score, uroflowmetry and post voiding residual urine were recorded and analyzed. Results After 4 weeks of treatment, the IPSS, uroflowmetry and residual volume were improved significantly, P 0.1. Conclusions Reduction of symptoms and improvements of uroflowmetry in BPH patients treated with ? blocker.might be initiated through different mechanisms.

ObjectiveThe possibility of the hyperplasi a of prostatic outer gland was studied with transrectal ultrasound (TRUS) guided biopsies. MethodsTwenty-seven prostatic outer glands in patients suspicious for prostatic cancer (PCA) were biopsied by TRUS guided, the total sites were 47. The same site was biopsied in sagittal and longitudinal section respectively. The hypoechoic lesion was biopsied 2 times if it was discovered in the outer gland. The histological results were diagnosed in double blind. Results Twenty prostatic inner glands looked symmetrical hyperplasia; 9 outer glands became thin because of the compression, there was no compressive sign in 18 patients; there was a hypoechoic lesion in outer gland of 3 patients. Benign prostatic hyperplasia was diagnosed in the specimens of 47 sites. ConclusionsThe hyperplasia of prostatic outer gland can occur like inner gland because it is glandular tissue.

Objective To evaluate the clinical value of repeat transrectal ultrasound (TRUS) guided biopsy in prostatic cancer (PCA). Methods Repeat TRUS guided biopsy was conducted on 54 patients of the previous benign TRUS guided biopsy at high risk of PCA. Postatic specific antigen ranged in 0.5- 90.0 ?g/L(mean 16.3 ?g/L). Twenty-nine patients were abnormal in digital rectal examination, 21 patients were abnormal in TRUS. Results Forty-seven patients had 2 consecutive times of the biopsy, 6 patients had 3 consecutive times, 1 patient had 4 consecutive times in 54 patients of repeat TRUS guided biopsy. The pathological finding was confirmed in 14 PCA ( 25.9%), and 31 benign prostatic hyperplasia, 5 prostatic intra-epithelial neoplasmia, 4 chronic prostatitis. Conclusions The detection of PCA will be increased by repeat TRUS guided biopsy at high risk of PCA after the previous benign TRUS guided biopsy.

Objective:To investigate the effects of pristimerin therapy on the functions of Th17 and Treg cells in patients with allergic asthma,and expore the function of immune factors in therapy on allergic asthma. Methods:Extracted mononuclear cells in pe-ripheral blood of patients with allergic asthma,and given pristimerin intervention in vitro. Then used fluorescence-activated cell sorting analysis to detect the contect of Th17 and Treg,enzyme-linked immunosorbent assay to detect cytokine production of IL-17 and TGF-β, and Real-time PCR to detect the contect of RORγT and Foxp3. Results: Compared with the control group, experimental group had reduced expression of CD4+IL-17+T cells ( Th17 cells) ,and increased expression of CD4+CD25+Foxp3+T cells ( Treg cells) ,which all had the statistical significance (P<0. 05);displayed decreased level of IL-17,and increased level of TGF-β,which all had the statistical significance (P<0. 05);had reduced expression of RORγT,and increased expression of Foxp3,which all had the statistical significance (P<0. 05). Conclusion: Pristimerin therapy can remit the unbalance of Th17/Treg in vitro,hinting this drug may regulate allergic asthma by influencing immunologic balance,which offers the theoretical support for pristimerin in clinical application.