Animals ; Carcinoma, Pancreatic Ductal ; genetics ; pathology ; Genes, ras ; genetics ; Humans ; Metaplasia ; MicroRNAs ; genetics ; Mutation ; Pancreatic Ducts ; pathology ; Pancreatic Neoplasms ; genetics ; pathology ; Pancreatitis ; genetics ; Signal Transduction

OBJECTIVE:To study the protection of XNSK on renal ischemical reperfusion injury model rats.METHODS:A total of60rats were randomized into sham operation group(without occlusion of renal arteries of both kidneys and admin?istered with0.1%dimethyl sulfoxide normal saline),control group(0.1%dimethyl sulfoxide normal saline),positive control group(administered with Shenfukang capsules)and XNSK(high,medium and low dose subgroups)group.Levels of serum creatinine(Scr),urea nitrogen(BUN)and malonaldehyde(MDA)in renal tissue,hemocuprein(SOD),active oxygen(ROS)and nitrogen monoxidum(NO)were determined respectively meanwhile the pathomorphology changes of tissues were observed.RESULTS:As compared with the control group,levels of Scr,BUN,MDA,ROS and NO in all the3(high,medium and low doses)XNSK subgroups(which were administered with drugs for7days before operation and undergone reperfusion once after operation)had a reduction while SOD level had an increase.And there was a mitigated pathomorphology change in nephridial tissues(P

Along with the globalization of science and technology, the investment on medical research has been increased gradually in recent years, which brings many challenges to the administration of scientific research. The traditional passive conception and model of research administration can no longer meet the needs of modern research development, and therefore changes are urgently needed. The function of research administration in modern medical research needs to be redefined and new characteristics will subsequently arise. The changes are believed helpful in promoting the efficiency of research funding and implementation of the research projects and further facilitating the transformation and application of research achievements.

Objective To evaluate the efficacy and safety of Xiao-fan-xi-ji in treatment of the post operation of mixed hemorrhoids. Methods198 patients were randomly divided into the treatment group(112 cases,treated by Xiao-fan-xi-ji for 15 days)and the control group(96 cases,treated by Potassium Permanganate for 15 days).The improvement of symptom,sign and quality of life scores were evaluated. ResultsThe experimental and control groups in age,sex 、ethnic and the degree of disease had no statistical significance(all P＞0.05).After 2,7 days treatment,major adverse reaction was observed.Compared two groups in postoperative pain and edema edge,there was significant difference between the two groups(P＜0.05).The average healing time in experimental group was shorter than control group.Compared with control group,the quality of life scores increased after the treatment,the differences had statistical significance(P＜0.05). ConclusionXiao-fan-xi-ji was effective in the treatment of patients with mixed hemorrhoids after the operation,it was worth being promoted.

With the rapid development of life sciences, translational medical sciences have a new significance recent years. Translational medical science aims to eliminate the barriers between clinical, pharmaceutical drug breakthroughs and basic research, to shorten the distance from bench to bed side, and to facilitate rapid patient benefits from medical sciences. Translational medical science concurrently agrees with modern 21st century research trends, as well as emphasizing upon Chinese goals of health and sanitation (hygiene science), preventing and treating disease to preserve and improve health standards and quality of life. Following a long-term self study model of integrating basic with clinic research since 1921, Peking Union Medical College Hospital in collaboration with a variety of basic medical science institutions recently and initiated a pilot project of translational medical science in China.

OBJECTIVE:To evaluate the effect of clinical pharmacist intervention on the application of antibiotics in patients with respiratory infection from our hospital. METHODS:Each 500 patients were selected from respiratory department of our hospi-tal during Jan. to Jun. in 2016 and Jul. to Dec. in 2016. The patients were divided into pre-intervention group and post-intervention group. The application of antibiotics,the occurrence of ADR and anti-infective effects were compared before and after clinical phar-macist intervention,and the rationality of antibiotics use was evaluated. RESULTS:After intervention,the utilization rate of antibi-otics decreased from 92.60％ to 74.20％;the proportion of single drug therapy and triple and more drugs therapy were decreased significantly,with statistical significance(P<0.05). The incidence of ADR reduced from 14.20％ to 5.80％;the rate of infection control increased from 95.03％ before intervention to 97.04％;antibiotics cost decreased significantly,with statistical significance (P<0.05). The incidence of irrational drug use,nonstandard dosage,irrational drug combination and no etiological support as well as total irrational rate decreased from 7.40％,3.60％,5.80％,7.80％,20.60％ to 4.00％,1.40％,2.00％,4.20％,9.60％,with statistical significance(P<0.05). There was no statistical significance in the proportion of double drug therapy or emergency and se-vere rescue rate (P>0.05). CONCLUSIONS:The intervention implemented by clinical pharmacists effectively reduce the utiliza-tion rate of antibiotics and the incidence of ADR,improve the rate of infection control,reduce antibiotics cost and the occurrence of irrational drug use. However,there are still some problems in respiratory department of our hospital,such as irrational drug use, nonstandard dosage,irrational drug combination and no etiological support,etc. Continuous follow-up intervention is needed.

DNA Mutational Analysis ; Drug Resistance ; genetics ; Genetic Variation ; Glucocorticoids ; pharmacology ; Humans ; Mutation ; Receptors, Glucocorticoid ; classification ; genetics ; physiology

Traditional treatments of gastrointestinal fistula include early drainage, maintaining nutrition and then resection of fistula at the proper time,which usually take three to four months or even longer. Rapid treatments of gastrointestinal fistula mean promoting rapid spontaneous closure of tract fistula and early primary resection of fistula within two weeks after fistula occurrence. Early diagnosis is the premise of early management, and fistulography and abdominal CT scan are important early diagnostic methods. Most of fistula could close spontaneously in the maintaining stage. To promote the rapid closure, however, special measures including sufficient drainage, somatostatin and total parenteral nutrition in the early stage should be implemented to avoid intra-abdominal collection of intestinal fluid and infection, control further leakage of intestinal fluid and improve nutritional status. In the late stage,when leakage of intestinal fluid could be controlled, recombine human growth hormone (rhGH) and enteral nutrition should be administered in place of somatostatin and total parenteral nutrition respectively. The fistula can reach rapid spontaneous closure in both stages. Fibrin glue and rhGH used at the same time can improve the curative rate and shorten the treatment time even more. In the 1960s and 1970s, early primary resection of the fistula and re-anastomosis often resulted in anastomosis failure. The reasons for this included poor nutritional status, uncontrolled secretion of intestinal fluid, severe intra-abdominal infection and multiorgan dysfunction syndrome. Such stage management policy has been proposed, developed and persisted since late 1960s. Nowadays, the advance of medical science provided the possibility to change or improve the current policy. Our research proved that early resection of the primary fistula and re-anastomosis of the small bowel could be performed successfully in some selected patients whose general conditions are good and intestinal adhesion were not severe within ten to fourteen days after fistula occurrence. More studies are still needed to define the indications and contradictions for early resection of the primary gastrointestinal fistula, and prove the feasibility and rationality of rapid treatments of gastrointestinal fistula.
Early Diagnosis ; Humans ; Intestinal Fistula ; diagnosis ; therapy ; Parenteral Nutrition, Total

Orthopaedic postoperative pain not only brings a lot of side effects to patients, but also directly affects early rehabilitation after surgery. Effective preoperative pain management mainly includes three-stage individual pattern analgesia, which refers to preoperative, intraoperative and postoperative analgesia. The purpose is to reduce pain in multiple planes and three-dimension, strengthen the effect of analgesics and reduce dosage and side effect of single drug. This paper summaries new progress on individual-multiple-pattern analgesics, pain assessment method and various therapies.
Analgesia ; methods ; Humans ; Orthopedics ; methods ; Preoperative Period ; Treatment Outcome

The idiopathic macular hole ( lMH ) is research priority associated with the regenerate quickly of vitrectomy. The unaided visual acuity and the best corrected visual acuity is partial for the visual acuity of the patient with lMH. The mechanism and clinical significance of modern visual function measurements associated with lMH, including contrast sensitivity, visual field, multifocal electroretinogram, and stereoscopic vision, have been introduced. These measurements could be of great value in early diagnosis of lMH, assessment of surgical indication and evaluation of visual performance after vitrectomy. They would also be helpful to the analysis of postoperative impaired visual function and its management. Having an adequate understanding of the contents and significance of visual function is helpful to the improvement of lMH surgery techniques and postoperative visual acuity.