Adolescent ; Humans ; Lung ; diagnostic imaging ; pathology ; Lung Neoplasms ; diagnostic imaging ; pathology ; surgery ; Male ; Papilloma ; diagnostic imaging ; pathology ; surgery ; Pneumonectomy ; methods ; Tomography, X-Ray Computed

Objective To reveal the trend of change incidence of hepatitis A(HAV)in Shandong province and explore dynamic analysis methods.Method Dynamic analysis was made on data of hepatitis A in Shandong province from 1990 to 2006.Results The reported incidence of hepatitis A patients dropped from 53.97/100,000 to 1.14/100,000 in Shandong province from 1990 to 2006,which showed a marked downward trend;the groups under the age of 10 dropped from 55.60% to 5.12%,the average age of incidence moved from 14.40 years old to 40.19 years old.Conclusion The incidence of hepatitis A has been changed from prevalent to sporadic in Shandong province,and there was a further downward trend;the age of the high-risk population has been shifted to older age group;the sex ratio of incidence between males and females in the population above 10 years of age had an expansion trend,the age distribution curve differences between males and females was also expanded.

Child ; Child, Preschool ; China ; epidemiology ; Evidence-Based Medicine ; Humans ; Kidney Diseases ; diagnosis ; epidemiology ; therapy ; Practice Guidelines as Topic

Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Drug Delivery Systems ; methods ; Drug Resistance, Neoplasm ; Humans ; Mutation ; Neoplasms ; drug therapy ; genetics ; pathology

Objective To explore the clinical application of array comparative genomic hybridization (aCGH) and karyotype a-nalysis in the prenatal evaluation of fetal with small supernumerary marker chromosome (sSMC) .Methods One case was indenti-fied with de novo small supernumerary marker chromosome .G-banding analysis indicated that the fetus had a karyotype of 47 , XY ,+Mar .aCGH was used to define the precise location and size of de novo chromosome .Results aCGH revealed that there was 2 .03 Mb duplication from 15q11 .1-q11 .2 in the fetus .aCGH revealed the presence of small supernumerary marker chromosome . Conclusion The technologies of aCGH can be used for identifying the origin of small supernumerary marker chromosome and defi-ning the loci of the chromosome .Combined with the karyotype analysis ,it can be applied to genetics analysis and prenatal diagnosis .

Objective To investigate the diagnostic value of ThinPrep cytology(TCT) combined with colposcopy for cervical lesions.Methods 980 patients with suspected cervical lesions were selected and received TCT combined with colposcopy examination.Among the 980 patients,102 patients with positive smear were referred for colposcopy and were diagnosed by colposcopy biopsy.Results Of 102 patients with positive smear,the detection rates of the atypical squamous cells (ASC),low-grade squamous intraepithelial lesions (LSIL),cervical intraepithelial neoplasia (HSIL) and atypical glandular cells (AGC) were 6.1％,0.6％,2.1％ and 1.5％,respectively.Compared with the colposcopy biopsy for cytology samples,the test results were as follows:LSIL was 72.4％ (21/29),HSIL was 93.8％ (15/16).Conclusion The method of TCT could increase the screening rate of positive diagnosis of cervical lesions and for the highly suspected patients,the combination of vaginal colposcopy and biopsy could further improve the accuracy of diagnosis,in order to provide scientific solutions for clinical treatment.

Objective To explore the risk factors analysis of patients with hemorrhagic stroke in Zhongshan district of Dalian city in order to providing the Corresponding intervention measures.Methods From Oct 2010 to Aug 2013,183 cases of patients with hemorrhagic stroke(age ＞ 60 years old) and 158 cases healthy physical people in Zhongshan Hospital Affiliated to Dalian University were served as observation group and control group.Clinical information and life habit of two groups were recorded,the height and weight were measured,body mess index (BMI) was calculated,blood lipid level and plasma fiber protein level were detected.Results The rate of male,age ＞70 years,BMI index ≥25 kg/m2,smoking,history of hypertension,TG ≥ 1.7 mmol/L,TC ≥ 5.7 mmol/L,fibrinogen ＜ 4.0 g/L in observation group were 68.85 ％ (126/183),65.03％ (119/183),61.75％ (113/183),77.05％ (141/183),32.24％ (59/183),51.37％ (94/183),62.30％ (114/183),68.31％ (125/183) respectively,higher than those of control group (51.90％ (82/158),44.94％ (71/158),39.87％ (63/158),17.72％ (28/158),18.99％ (30/158),29.11％ (46/158),36.08％ (57/158),82.91％ (131/158),the differences were statistically significant (x2 =8.725,27.167,12.742,95.064,5.825,14.056,18.478,7.314,P ＜ 0.05).However,there were no significant differences in terms of diabetes history,drinking,high density lipoprotein-cholesterol level and low density lipoprotein-cholesterol between two groups.Conclusion Hemorrhagic stroke is closely related to many factors.Sex,age ＞ 70 years,smoking,obesity,history of hypertension,high cholesterin (TC ≥ 5.7 mmol/L) are independent risk factors of patients with hemorrhagic stroke in elderly.Through the control target population's blood pressure and blood lipids,rational diet,appropriate exercise,quit smoking and alcohol,adjust the good point of view,we can prevent the occurrence old hemorrhagic stroke.

The clinical evaluation system for therapeutic effects of tumor, which focuses on survival period and tumor response rate, has been proved not very proper for evaluating the therapeutic effects of traditional Chinese medicine (TCM). Quality of life (QOL) has been introduced into the effective evaluation system of TCM and integrative medicine because of its similarity in concept and extension with TCM at theory basis, syndrome differentiation-treatment, and evaluation of therapeutic effects. But there are no QOL questionnaires which can evaluate the therapeutic effects of TCM and integrative medicine precisely. This article discussed the necessity and significance of developing QOL questionnaire special for TCM.

Objective To observe the efficacy of comprehensive strategies in treating diabetic foot.Methods Thirty five cases with diabetic foot were treated by comprehensive strategies,including antiinfection,strict blood sugar control,vasodilatation,improvement of microcirculation,never nutrition,debridement and supportive care,etc.Results Among the 35 patients with diabetic foot,24 were recovered satisfactorily,7 cases were recovered with improvement,2 cases underwent amputation and 2 cases gave up further treatment.Conclusion Diabetic foot can be treated by comprehensive measures satisfactorily,with improved cure rate and low amputation rate.

Sepsis has become a widespread and very complex issue for modern critical care medicine.It is undoubtedly of great theoretical and clinical significance that we should strengthen the study of sepsis and explore new treatments and drugs.It has been found that curcumin had anti-tumor,anti-inflammatory,anti-virus,antibacterial,antioxidant and other pharmacological effects,low toxicity,and a good potential for clinical application.Moreover,it was thought to be potentially immunomodulatory in the last two decades.A number of experimental studies had elicited that curcumin could be used for sepsis and septic shock.This article reviews the immune regulation mechanism of curcumin in sepsis.