Adolescent ; Humans ; Lung ; diagnostic imaging ; pathology ; Lung Neoplasms ; diagnostic imaging ; pathology ; surgery ; Male ; Papilloma ; diagnostic imaging ; pathology ; surgery ; Pneumonectomy ; methods ; Tomography, X-Ray Computed

Objective To reveal the trend of change incidence of hepatitis A(HAV)in Shandong province and explore dynamic analysis methods.Method Dynamic analysis was made on data of hepatitis A in Shandong province from 1990 to 2006.Results The reported incidence of hepatitis A patients dropped from 53.97/100,000 to 1.14/100,000 in Shandong province from 1990 to 2006,which showed a marked downward trend;the groups under the age of 10 dropped from 55.60% to 5.12%,the average age of incidence moved from 14.40 years old to 40.19 years old.Conclusion The incidence of hepatitis A has been changed from prevalent to sporadic in Shandong province,and there was a further downward trend;the age of the high-risk population has been shifted to older age group;the sex ratio of incidence between males and females in the population above 10 years of age had an expansion trend,the age distribution curve differences between males and females was also expanded.

Medical Oncology ; trends

Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Drug Delivery Systems ; methods ; Drug Resistance, Neoplasm ; Humans ; Mutation ; Neoplasms ; drug therapy ; genetics ; pathology

The prevalence of esophageal cancer in China is significant. Surgery remains to be the mainstay treatment for esophageal cancer. Standardized surgical procedure and radical lymph node dissection is the base of multimodality treatment, which is also related to the success of the treatment and prognosis. At present, synchronized preoperative chemoradiation is recommended for operable esophageal cancer. Use of preoperative radiation is not associated with increased difficulty in performing surgery or increased complications. Preoperative chemotherapy alone is not recommended. NCCN recommends 5-fluorouracil-based adjuvant therapy administered synchronously with radiation. In China, postoperative synchronized chemoradiation is recommended for II(B-III) esophageal cancer. Large-scale, multi-center, prospective controlled clinical trials are warranted to determine the optimal combination of therapeutic alternatives to benefit patients the most.
Combined Modality Therapy ; Esophageal Neoplasms ; therapy ; Humans

Carcinoma, Squamous Cell ; diagnosis ; therapy ; China ; Combined Modality Therapy ; Esophageal Neoplasms ; diagnosis ; therapy ; Esophagectomy ; methods ; Esophagoscopy ; Humans ; Neoplasm Staging ; Practice Guidelines as Topic ; standards ; Research

Antineoplastic Agents ; therapeutic use ; Carcinoma, Non-Small-Cell Lung ; drug therapy ; surgery ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Humans ; Lung Neoplasms ; drug therapy ; surgery ; Molecular Targeted Therapy ; Neoadjuvant Therapy

Biomarkers, Tumor ; genetics ; metabolism ; Humans ; Molecular Targeted Therapy ; standards ; Mutation ; Neoplasms ; drug therapy ; genetics ; metabolism ; pathology

Biomarkers, Tumor ; analysis ; Diagnosis, Differential ; Diagnostic Errors ; Humans ; Irritable Bowel Syndrome ; pathology ; Lymphoma, B-Cell ; pathology ; Oncogene Proteins, Fusion ; analysis ; Sarcoma, Synovial ; chemistry ; pathology

Carcinoma, Neuroendocrine ; pathology ; Carcinoma, Pancreatic Ductal ; pathology ; Carcinoma, Papillary ; pathology ; Concept Formation ; Humans ; Neuroendocrine Tumors ; pathology ; Pancreatic Neoplasms ; classification ; pathology ; World Health Organization