Adolescent ; Humans ; Lung ; diagnostic imaging ; pathology ; Lung Neoplasms ; diagnostic imaging ; pathology ; surgery ; Male ; Papilloma ; diagnostic imaging ; pathology ; surgery ; Pneumonectomy ; methods ; Tomography, X-Ray Computed

Many problems have been found in the inspection of assets in universities conducted　by the Ministry of Finance,Accordingly,some measures were taken to solve the problems,and as a　result the management was enhanced and the efficiency of the assets were improved.The author,　working in the front line of the inspectiong,reported the experience and in-depth reflection over the　experience to propose for the management of laboratories in medical colleges.

Disrupted pancreatic ?-cell function and decreased ?-cell number are two of the main causes of type 2 diabetes mellitus.Recent studies have indicated that autophagy plays an important role in protecting pancreatic ?-cell and in maintaining the structure,number,and secretive function of pancreatic ?-cell.Although autophagy has been a focus of study in recent years,including areas such as tumor,neural diseases and aging,but its relationship with pancreatic ?-cell was not included.In this paper we review the concept of autophagy and its role in maintaining the normal function of pancreatic ?-cells.

AIDS has become a devastating disease facing human around the world.Western medicine can reduce blood HIV load,thereby promoting recovery of immune function. With the extensive application of HAART,many unsolvable problems appear.There is much experience in treatment for infectious diseases in TCM.So,it is necessary and feasible to treat AIDS with TCM.Combination of Chinese and western medicine will achieve complementary advantages and may be a new model for AIDS treatment.Many researchers carry out study on it,but there are still a lot to do to improve the drawbacks.

Aim Background tumor necrosis factor-alpha (TNF-?) is produced by monocyte-macrophages and adipocytes. It may provide the link between inflammation and atherosclerosis. The aim of this study was to evaluate the effect of fenofibrate on serum TNF-? concentration and TNF-? secretion by adipocytes from hypercholesterolemia rabbits.Methods Ten male New Zealand white rabbits were fed with high-cholesterol diet for 8 weeks, and were randomly divided into two groups: ①high cholesterol group: maintained cholesterol diet for 4 wks; ② fenofibrate group: the same cholesterol diet supplemented with fenofibrate (30 mg?kg?d -1) for 4 weeks. And control group was fed with normal diet for 12 weeks. Subcutaneous adipose was collected for adipocytes culture. TNF-? concentrations in serum and adipocytes culture supernatant were measured by ELISA. Adipocytes were harvested for semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) studies. Results :Rabbits fed with high-cholesterol diet showed higher serum levels of total cholesterol, low density lipoprotein cholesterol than those fed with normal diet (P

Objective To comprehend the etiology and the clinical characteristics of hypereosinophilia.Methods The clinical data of 53 patients with hypereosinophilia admitted to Peking Union Medical College Hospital from November 1992 to February 2005 were analyzed.Results The causes of reactive hypereosinophilia included allergic diseases,infections,connective tissue diseases,malignant diseases,lung diseases,eosinophilic gastroenteritis.idiopathic hypereosinophilic syndrome had longer course of disease;more organ involved than reactive causes.The incidence of lymph node enlargement,spleen enlargement and thrombus was higher than the reactive.IHES had higher level of white blood cell count,absolute eosinophilic count,IgG and CRP.Conclusion The etiology and clinical characteristics of hypereosinophilia are various,so the differential diagnosis of hypereosinophilia is very important.

Objective To analyze the clinical effect and safety of cortical bone decortication combined locking plate fixation for treatment of long bone nonunion of limbs. Methods Eighty patients with long bone nonunion of limbs who were treated in the Zhongshan Hospital Affiliated to Dalian University from Jun. 2010 to Jun. 2013 were selected as our subjects and their clinical data were recorded. According to different treatment methods,the patients were divided into control group and observation group,and each group with 40 cases. Patients in observation group were treated with cortical bone decortication combined locking plate fixation, while in control group were treated with locking plate combined slotted bone graft. Clinical effects and safety of two groups were compared. Results Excellent and good rate in observation group was 100%(40/40),obviously higher than that of control group(90. 0%(36/40);χ2 =4. 21,P﹤0. 05). Bleeding amount during operation in observation group was(370. 5 ± 56. 5)ml,obviously less than that of control group((486. 5 ± 64. 5)ml;t=8. 56,P﹤0. 01). And the fracture healing time was(5. 6 ± 1. 2)months in observation group,shorter than control group((7. 2 ± 1. 5)months;t =5. 27,P ﹤0. 01). The postoperative complication occurrence rate was 5. 0%(2/40),significantly lower than control group(20. 0%(8/40);χ2 =4. 11,P ﹤0. 05). Conclusion Cortical bone decortication combined locking plate fixation for treatment of long bone nonunion of limbs is safe and effective,and it can reduce operation injury and accelerate postoperative healing of fracture.

MicroRNA (miRNA) constitutes a group of small (21-23 nucleotide) noncoding RNAs that functional as posttranscriptional gene regulators.miRNA involved in the tumor development which have been suggested to play a vital role in operating to promote or suppress tumor proliferation,invasion and metastasis.The application value of miRNA as a potential biomarker was also discussed.It needs to be further explored that miRNA can be applied as biomarkers in further medical paractice.

Objective To investigate the clinical characteristics of the patients with central brain herniation,and the operation effect of high coronary craniotomy for bilateral decompressive craniectomy.Methods A retrospective analysis was conducted on 26 cases of central brain herniation.The effectiveness of high coronary craniotomy for bilateral decompressive craniectomy and the influential factor of prognosis in patients with central brain herniation were analyzed.Results According to the Glasgow outcome score (GOS) 6 months after operation,5 cases were recovered well,6 cases moderately disabled,4 cases severely disabled,3 cases vegetative survived and 8 cases died.Conclusions High coronary craniotomy and timely and effective bilateral decompressive craniectomy are the most important treatment in patients with central brain herniation.The prognosis is unfavourable prognosis in patients with central brain herniation within 1 h after injury and older than 75 years old.

Early recognition of severe sepsis and septic shock,early initiation of effective interventions,implementation of early goal-directed therapy may be key approaches for reducing the mortality and improving the prognosis.This article focused on the staging diagnosis systems for sepsis (PIRO sepsis classification system) and the systematic early warning or rapid response system.We also discussed the diagnostic value of biomarkers,proteomics and metabolomics in sepsis and severe sepsis.No single marker as golden standard has emerged that can provide clinicians with all the information they need for early recognition of sepsis.Therefore,we suggested that clinicians should have even more reason to combine the sepsis symptoms,signs and biomarkers for a comprehensive evaluation,and that they needed to dynamically monitor the changes in these parameters,in order to make reasonable clinical decisions and strategies.