Endomyocardial biopsy and hemodynamic study were made with the heart catheterization in 8 patients with Keshan disease. The procedure was performed smoothly and safely in all patients, without complications. Endomyocardial tissues were obtained from these eight patients. Light and electronmicroscopic observations showed that the endocardium is normal in all biopsy specimens, but abnormal morphologic findings, such as degeneration of the myocardiaum, hypertrophy of muscle fibers, old scars, etc., were present in all patients. Infiltration of interstitial fatty tissue was found in 4 cases. Heart catheterization. 2 patients with latent Keshan disease were normal. There was an increase in the pulmonary arterial pressure in 5 out of 6 patients with chronic type, and 2 showed distinct pulmonary arterial hypertension. Thus, endomyocardial biopsy may be regarded as a better method to examine the myocardium, and it is of value in diagnosis and prognosis.

Twelve patients with latent Keshan disease in Xunyi County,Shaanxi Province were electron-microscopically observed with endomyocardial biopsy. Seven of them were males, 5 females; their ages ranged from 14 to 40 years old. They had suffered from the disease for 4 to 5 years in an average. The samples taken from their heart ventricles were prepared in routine,some were prepared with the modified lanthanum preparation according to Hoffstein's method to study the membrane permeability of the patients' myocardium at the same time,In almost all the samples, most of sarcoplasmic reticula,transverse tubule system and intercalated disc spaces are dilated. In some samples prepared with the lanthanum preparation, the electronic density particles are found in the intercalated disc spaces and scarcely in the cytoplasm of myocardium. Mitochondria often show changes both of proliferation and of degeneration simutaneously. Sometimes, minimal myolytic changes of filaments also can be seen, but there are no any necrotic or myolytic foci of myocardium found in the samples at all. Some nuclei are enlarged and twised,in them some pseudoinclusions also can be occasionally seen. Myofibrils vary their thickness. At the same time, they also have some abnormal branches. More than normal amount of fat droplets and glycogen granules deposite in the myocardial cells. Besides,there are lots of lipofusicin granules accumulated around the nuclei in the cytoplasm.

Objective:To explore the relationship of sleep quality and sleep duration with hypertension among adults aged 30-79 years old in Guangzhou.Methods:According to multi-stage stratified cluster sampling, 12 747 residents aged 30-79 years old were sampled and surveyed in Guangzhou from January 2018 to March 2019. Data on general demographic characteristics, sleep quality, sleep duration and hypertension were collected through questionnaire survey, the Pittsburgh sleep quality index (PSQI) and physical examination. Multivariate logistic regression models were used to analyze the putative association between sleep quality, sleep duration and hypertension. Restrictive cubic spline curve was used to draw the dose-response relationship curve between sleep quality, sleep time and hypertension.Results:The mean age of the subjects was (52.68±12.17) years, the prevalence of hypertension was 36.6% (4 664/12 747), the average score of PSQI was (4.70±2.88), and the average sleep time was (7.00±1.32) hours. The prevalence of hypertension was positively associated with the PSQI score. Compared to the subjects with a score less than 3, OR (95% CI) of hypertension with a PSQI score of 3-5, 5-8, ≥9 were 1.14 (1.02-1.27), 1.17 (1.03-1.34), 1.41 (1.21-1.64), respectively. The relationship between sleep duration and hypertension appeared U-shaped. Compared with 6 to 8 hours sleep duration, both sleep duration<6 hours with OR(95% CI) of 1.27(1.12-1.43) or >8 hours with OR(95% CI) of 1.20(1.05-1.38) was associated with hypertension. Conclusion:Both poor sleep quality, longer or shorter sleep duration were responsible for increased risk of cognitive impairment in older Chinese.

Objective:To explore the relationship of sleep quality and sleep duration with hypertension among adults aged 30-79 years old in Guangzhou.Methods:According to multi-stage stratified cluster sampling, 12 747 residents aged 30-79 years old were sampled and surveyed in Guangzhou from January 2018 to March 2019. Data on general demographic characteristics, sleep quality, sleep duration and hypertension were collected through questionnaire survey, the Pittsburgh sleep quality index (PSQI) and physical examination. Multivariate logistic regression models were used to analyze the putative association between sleep quality, sleep duration and hypertension. Restrictive cubic spline curve was used to draw the dose-response relationship curve between sleep quality, sleep time and hypertension.Results:The mean age of the subjects was (52.68±12.17) years, the prevalence of hypertension was 36.6% (4 664/12 747), the average score of PSQI was (4.70±2.88), and the average sleep time was (7.00±1.32) hours. The prevalence of hypertension was positively associated with the PSQI score. Compared to the subjects with a score less than 3, OR (95% CI) of hypertension with a PSQI score of 3-5, 5-8, ≥9 were 1.14 (1.02-1.27), 1.17 (1.03-1.34), 1.41 (1.21-1.64), respectively. The relationship between sleep duration and hypertension appeared U-shaped. Compared with 6 to 8 hours sleep duration, both sleep duration<6 hours with OR(95% CI) of 1.27(1.12-1.43) or >8 hours with OR(95% CI) of 1.20(1.05-1.38) was associated with hypertension. Conclusion:Both poor sleep quality, longer or shorter sleep duration were responsible for increased risk of cognitive impairment in older Chinese.