Objective To observe the effet of gross saponin of tribulus terrestris(GSTT) on hemodynamics and oxygen metabolism in anesthetic thoraco-opened dogs.Methods Thirty dogs were randomly divided into negative control,positive control,and experimental groups(GSTT of 6.26,12.52,and 25.00 mg?kg~(-1))(n=6).The administration of intravenous injection was used.The effects of GSTT on the indexes of the hemodynamics and oxygen metabolism in anesthetic thoraco-opened dogs were observed.Results Compared with controls GSTT increased myocardial blood flow(CBF)(P

Aim To investigate the effect of prenatal alcohol on insulin sensitivity of rat offspring and its underlying mechanism. Methods Female Sprague Dawley rats were given ethanol 4 g?kg-1?d-1 by gavage throughout pregnancy. At 16 wk of age, the rat offsrping underwent intravenous glucose tolerance test. The mRNA level of adipose leptin, resistin and adiponectin were determined by RT-PCR. Serum leptin, resistin and adiponectin were measured with RIA kits. Results Newborn ethanol rats had lower birth weight than control [(5.7?0.1) g vs (6.9?0.1) g,P

Objective To study the effecet of oxidized low-density lipoprotein(Ox-LDL) on endothelium-dependent relaxation and mechanism of susceptibility to atherosclerosis(AS) in hyperlipdemic male patients.(Methods)LDL isolated from 13 normal patients and 29 hyperlipidemic patients were modified by CuSO_4.The amount of malondialdehyde(MDA) was measured by TBARS.The amount of lysophosphatidylcholine(LPC) was determined by the Bartlett.Endothelium-dependent relaxation was produced by acetylcholine.Results After LDL from normal and hyperlipidemic patients were modified by CuSO_4,the amount of MDA was increased(P