1.Report on recent use of PET-CT in lymphoma in the 54th ASH annual meeting
Jiazhu WU ; Wei XU ; Jianyong LI
Journal of Leukemia & Lymphoma 2013;22(1):11-12,16
Positron emission tomography-computed tomography (PET-CT) with both anatomic and functional information is now widely utilized for most lymphoma subtypes,among which,the pretreatment staging and response assessment of PET-CT in Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL)have been well documented.Multiple clinical trials are ongoing using PET-CT for therapy monitoring.Additionally,factors interpreting interim PET (PET-i) like visual analysis using Deauville 5-PS,metabolic tumor volume at baseline (MTV0),and △ SUVmaxPET0-i show different prognostic values.However,the management of PET-CT in lymphoma is still elusive,further trials remain to be done to get evidences for the use of PET-CT in guiding therapeutic decisions.
3.CHANGES OF LEVEL OF IL-1 PRODUCED BY PERIPHERAL BLOOD MONOCYTES IN PATIENTS WITH SCHISTOSOMIASIS JAPONICA IN VITRO
Zujin LI ; Duande LUO ; Xinxing WU ; Qing YANG ; Linglan ZHENG ; Shuli LI ; Yuexiang YANG ; Huocheng WANG ; Jiazhu DAI ; Xinhe WANG
Chinese Journal of Schistosomiasis Control 1989;0(01):-
Activity of IL-1 produced by peripheral blood monocytes stimulated with lipopolysaccharide in vitro was detected from 17 acute cases, 14 chronic cases and 19 advanced cases of schistosomiasis japonica. It was found that the level of IL-1 was significantly increased and positively related to the body tempereture in the group with acute schistosomiasis. The activity of IL-1 was statistically reduced in the chronic and advanced groups, especially in the latter. After inhibiting the synthesis of prostaglandin with indomethacin, the level of IL-1 was significantly increased in three groups of patients, but no apparent change in the normal contro group. The results indicate that IL-1 may play an important role in inducing the inflammatory reaction in patients with acute schistosomiasis japonica and in the immunoregulation in the chronic stage. The changes of IL-1 activity in patients with schistosomiasis japonica may be closely related to prostaglandin.
4.Association of serum transforming growth factor-β1 with radiation injury and survival of patients with early-stage nasopharyngeal carcinoma.
Guorong ZOU ; Xiaohui LIN ; Jiehong WU ; Jiazhu HU ; Chao ZHANG ; Jishi LI ; Yihua LI ; Xiaolong CAO
Journal of Southern Medical University 2012;32(8):1171-1174
OBJECTIVETo observe the changes in serum transforming growth factor-β1 (TGF-β1) in patients with early-stage nasopharyngeal carcinoma (NPC) after radiotherapy and explore the correlation of serum TGF-β1 with radiation injury and disease-free survival.
METHODSThe average serum TGF-β1 level (50.2∓3.2 ng/ml) determined from 32 healthy volunteers was used as the standard value for NPC patients in this trial. Fifty-seven patients with early-stage (T1-2N0-1M0) NPC without prior treatment were divided into two groups with serum TGF-β1 level before treatment lower than or equal to the standard value (group A, 29 cases) and a level beyond the standard value (group B, 28 cases). Serum TGF-β1 level was determined in all the patients before, during and after the radiotherapy to evaluate the radiation injury and therapeutic effect.
RESULTSThe serum TGF-β1 level before radiotherapy was significantly lower in group A than in group B (35.4∓1.4 vs 58.8∓1.0 ng/ml, P<0.05). After radiotherapy, acute radiation mucositis and skin reaction was significantly severer in group B (P<0.05). The serum TGF-β1 level before radiotherapy was significantly higher in patients with grade 3 acute radiation mucositis and skin reaction than in those with injuries below grade 3 (54.0∓2.2 vs 42.0∓2.3 ng/ml and 54.3∓2.4 vs 43.4∓2.2 ng/ml, P<0.05). The two groups showed no significant differences in the locoregional failure rate (3.4% vs 7.1%), distant metastasis rate (3.4% vs 10.8%) or disease-free survival (P>0.05).
CONCLUSIONSRadiotherapy can significantly decrease serum TGF-β1 level in early NPC patients. Serum TGF-β1 level before radiotherapy can help predict the degree of acute radiation mucositis and skin reaction, but shows no correlation with disease-free survival of early-stage NPC patients.
Carcinoma ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; blood ; mortality ; radiotherapy ; Radiation Injuries ; blood ; Survival Rate ; Transforming Growth Factor beta1 ; blood
5. Prognostic value of lymphocyte-to-monocyte ratio in angioimmunoblastic T cell lymphoma
Junying NIU ; Huayuan ZHU ; Li WANG ; Lei FAN ; Jinhua LIANG ; Lei CAO ; Wei WU ; Yi XIA ; Jiazhu WU ; Jianyong LI ; Wei XU
Chinese Journal of Hematology 2018;39(4):265-270
Objective:
To evaluate the prognostic value of lymphocyte-to-monocyte ratio (LMR) in angioimmunoblastic T cell lymphoma (AITL).
Methods:
Data of 64 patients diagnosed as AITL at the First Affiliated Hospital of Nanjing Medical University between June 2009 and July 2017, were analyzed retrospectively. Receiver Operator Characteristic (ROC) curve was used to calculate the cutoff value of LMR to divide this cohort of patients into high and low LMR groups. Characteristics between groups were compared by Pearson Chi-square or Fisher exact tests. Kaplan-Meier method and Cox regression were performed to probe prognostic factors associated with progression-free survival (PFS) and overall survival (OS).
Results:
A total of 64 cases [39 cases male and 25 ones female with the median age of 63 (29-89) years old] were enrolled. The cutoff value of LMR was 3.07. Patients with low LMR showed inferior PFS (9 months
6. A retrospective analysis of clinical characteristics and prognostic factors for 124 cases of primary gastric lymphomas
Yan HE ; Li WANG ; Huayuan ZHU ; Jinhua LIANG ; Wei WU ; Jiazhu WU ; Yi XIA ; Lei CAO ; Lei FAN ; Jianyong LI ; Wei XU
Chinese Journal of Hematology 2017;38(6):505-510
Objective:
To analyze the clinical characteristics, treatment and prognosis of primary gastric lymphomas (PGL).
Methods:
A retrospective study was conducted in 124 cases of PGL from July 2009 to January 2016 in our hospital, and the clinical records, pathological and immunohistochemical features were analyzed. The relationship between different factors at diagnosis and prognosis were studied.
Results:
124 cases of PGL included 93 diffuse large B cell lymphoma (DLBCL) patients, 25 mucosa associated lymphoid tissue (MALT) lymphoma cases, 1 mantle cell lymphoma, 4 peripheral T-cell lymphoma-not otherwise specified, and 1 extra-nodal NK/T-cell lymphoma-nasal type. Of the 93 primary gastric DLBCL (PG-DLBCL) patients, the germinal center B cell-like (GCB) DLBCL were 45 cases, non-GCB DLBCL were 48 cases. 10 cases (10.8%) of 93 PG-DLBCL were transformed from gastric MALT, and 7 cases (7.5%) have bone marrow involvement. Evidence of Helicobacter pylori infection was detected in 21 cases (51.2%) of 41 DLBCL patients and in 10 cases (43.5%) of 23 MALT patients. Univariate analysis revealed that clinical stages (
7.Clonotypic analysis of immunoglobulin heavy chain sequences among 44 patients with Waldenström macroglobulinemia.
Jing TANG ; Yi XIA ; Hua YIN ; Li WANG ; Jiazhu WU ; Ruize CHEN ; Jinhua LIANG ; Huayuan ZHU ; Lei FAN ; Jianyong LI ; Wei XU
Chinese Journal of Medical Genetics 2023;40(3):263-268
OBJECTIVE:
To analyze the correlation between the mutational status of immunoglobulin heavy chain variable (IGHV) gene with the prognosis of patients with Waldenström macroglobulinemia (WM).
METHODS:
Immunoglobulin heavy chain gene (IGH) clonotypic sequence analysis was carried out to assess the mutational status of IGHV in the blood and/or bone marrow samples from 44 WM patients. The usage characteristics of IGHV-IGHD-IGHJ gene was explored.
RESULTS:
The most common IGHV subgroup was IGHV3, which was similar to the data from the Institute of Hematology of Chinese Academy of Medical Science. IGHV3-23 (20.45% vs. 15.44%) and IGHV3-74 (11.36% vs. 7.35%) were the main fragments used, which was followed by IGHV4 gene family (15.91% vs. 24.26%). However, no significant correlation was found between the IGHV4 usage and the prognosis of the patients. Should 98% be taken as the cut-off value for the IGHV mutation status, only 5 patients had no IGHV variant, and there was no correlation with the prognosis. Based on the X-tile analysis, 92.6% was re-selected as the cut-off value for the IGHV variant status in such patients. LDH was increased in 26 patients (59.1%) without IGHV variant (P < 0.05), whilst progression-free survival (P < 0.05) and overall survival (P < 0.05) were significantly shorter compared with those with IGHV variants.
CONCLUSION
The usage characteristics of IGHV-IGHD-IGHJ in our patients was similar to reported by the Institute of Hematology of Chinese Academy of Medical Science, albeit that no correlation was found between the IGHV4 usage and the prognosis of the patients. Furthermore, 98% may not be appropriate for distinguishing the IGHV variant status in WM patients.
Humans
;
Immunoglobulin Heavy Chains/genetics*
;
Multigene Family
;
Mutation
;
Waldenstrom Macroglobulinemia/genetics*
8. Survival analysis of 118 chronic lymphocytic leukemia patients with abnormal TP53 gene in the era of traditional immunochemotherapy
Xiaotong LI ; Huayuan ZHU ; Li WANG ; Yi XIA ; Jinhua LIANG ; Jiazhu WU ; Wei WU ; Lei CAO ; Lei FAN ; Wei XU ; Jianyong LI
Chinese Journal of Hematology 2019;40(5):378-383
Objective:
To analyze the survival and first-line immune-chemotherapy (CIT) of chronic lymphocytic leukemia (CLL) with abnormal TP53 gene in the era of traditional CIT.
Methods:
The clinical data of 118 CLL patients diagnosed from January 2003 to August 2017 were collected. Survival was analyzed according to indicators including sex, age, Binet risk stratification, B symptoms, β2-microglobulin (β2-MG) , immunoglobulin heavy chain variable region gene (IGHV) mutation status, chromosome karyotype and TP53 gene deletion/mutation. The efficacy of first-line CIT of 101 CLL patients was further analyzed.
Results:
Among 118 patients, median progression-free survival (PFS) was 12 (95%
9. The prognostic significance of peripheral lymphocyte/monocyte ratio and PET-2 evaluation in adult Hodgkin’s lymphoma
Tao JIA ; Huayuan ZHU ; Li WANG ; Jinhua LIANG ; Lei CAO ; Yi XIA ; Jiazhu WU ; Wei WU ; Lei FAN ; Jianyong LI ; Wei XU
Chinese Journal of Hematology 2019;40(5):372-377
Objective:
To evaluate the prognostic value of lymphocyte to monocyte ratio (LMR) and PET scan performed after first two cycles of chemotherapy (PET-2) in Hodgkin’s lymphoma (HL) .
Methods:
The clinical data of 133 patients with HL diagnosed from January 2007 to March 2016 at the First Affiliated Hospital of Nanjing Medical University, were retrospectively analyzed. The X-tile software was used to calculate the optimal cut-off value of LMR. Kaplan-Meier method and Cox regression were used for survival analysis.
Results:
The median age of 133 HL patients was 33 (18–84) years, and the male to female ratio was 1.9∶1. The optimal cut-off value of LMR was 2.5, and progression free survival (PFS) (
10.Chidamide-BEAC plus autologous stem cell transplantation in high-risk non-Hodgkin lymphoma: a phase II clinical trial.
Yi XIA ; Li WANG ; Kaiyang DING ; Jiazhu WU ; Hua YIN ; Maogui HU ; Haorui SHEN ; Jinhua LIANG ; Ruize CHEN ; Yue LI ; Huayuan ZHU ; Jianyong LI ; Wei XU
Chinese Medical Journal 2023;136(12):1491-1493