Objective To summarize the X-ray and CT manifestations of dialysis- related osteoarthropathy. Methods The study consisted of 20 cases with long-term dialysis patients. The X-ray and CT scanning of their shoulder, knee, hip, wrist and cervical vertebrae were performed respectively. The X-ray and CT manifestations of dialysis- related osteoarthropathy were observed. Results The roentgenographic and CT features included:universal osteoporosis(n=20), bone resorption(n=17), bone sclerosis(n=15), calcification(n=19) . Conclusion X-ray and CT are of significance in diagnosing bone resorption and calcification.

Objective:To explore the effect of hanging electronic baking lamp on the quality and progress of flap recovery in patients with hand injury flap repair.Methods:A total of 180 patients undergoing hand injury flap repair in Yantaishan Hospital in Yantai City from January 2019 to May 2022 were selected as the research objects by the convenient sampling method. They were divided into the control group and the observation group, with 90 cases in each group. The control group was treated with routine nursing combined with ordinary baking lamp nursing, while the observation group was treated with routine nursing combined with hanging electronic baking lamp nursing. The postoperative flap recovery quality (survival rate, healing grade) and recovery process (exudation drying time, the regression time of swelling , the healing time of flap wound) were compared between the two groups.Results:In the control group, 85 flaps survived, with a survival rate of 94.44% (85/90) ; in the observation group, 87 flaps survived, with a survival rate of 96.67% (87/90) ; there was no statistically significant difference in the results between the two groups ( P>0.05) . In the control group, there were 43 cases of grade A skin flap healing, 26 cases of grade B skin flap healing and 21 cases of grade C skin flap healing; in the observation group, 63 cases had grade A healing, 16 cases had grade B healing and 11 cases had grade C healing; there was statistically significant difference in the level of skin flap healing between the two groups of patients ( P<0.05) . The exudation drying time were (3.79±1.22) d in the observation group and (3.21±1.38) d in the control group; the regression time of swelling were (5.23±1.06) d in the observation group and (3.89±1.19) d in the control group; the healing time of the flap wound in the observation group was (12.36±2.58) d, while in the control group it was (8.98±1.47) d; the differences were all statistically significant ( P<0.05) . Conclusions:The use of a hanging electronic baking lamp after surgery can improve the quality of skin flap recovery for patients undergoing hand injury flap repair and accelerate their recovery progress.

Objective To explore the effectiveness of a nutritional intervention in rescuers who screened positive for depression. Methods A randomized controlled trial design was employed.From June to August,2022,4,460 rescuers were screened using the Self-Rating Depression Scale(SDS),and 1,615 positive cases were identified.Thirty-one volunteers were recruited and randomly divided into a nutritional intervention group and a control group.The intervention group received health education and nutritional intervention(a compound paste therapy primarily composed of red roses and Seville orange flowers),while the control group received psychological education.SDS scores were assessed before and after the intervention. Results There was a statistically significant decline in SDS scores in the nutritional intervention group after the intervention(P<0.05).Furthermore,the SDS scores of the intervention group were significantly lower than those of the control group,both before and after the intervention(P<0.05).No severe adverse reactions were observed during safety evaluation. Conclusion The nutritional intervention effectively reduced the depression scores in rescuers.Early nutritional intervention is recommended for rescuers who initially screen positive for depression.

Cases of breast skin thinning and lesion after augmentation mammoplasty by the injection of artificial filler were rarely reported. They are extremely difficult to treat with conventional methods, which will damage the blood supply and lay the risk of the necrosis of the nipple-areola complex (NAC) and the thin area of the skin. This paper introduces 2 cases of breast skin thinning and lesion after augmentation mammoplasty by the injection of unknown artificial filler in Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College in July and Novemeber 2021 respectively. With the water-jet force system assisted surgery, the artificial filler scattered in the subcutaneous superficial and partial deeper layers was effectively removed with the impact of water flow, while avoiding the compromise of blood supply and necrosis to the NAC and the breast skin.

Previous studies on adipogenesis mainly focused on induction culture in vitro. With the update of lineage tracing method, combined with the rapid development of single-cell sequencing in recent years, more comprehensive evidences have been obtained on the source and differentiation trajectory of adipocyte lineage in different states in vivo. In this paper, studies on the new-found sources of adipocyte tissue regeneration in vivo are reviewed.

Cases of breast skin thinning and lesion after augmentation mammoplasty by the injection of artificial filler were rarely reported. They are extremely difficult to treat with conventional methods, which will damage the blood supply and lay the risk of the necrosis of the nipple-areola complex (NAC) and the thin area of the skin. This paper introduces 2 cases of breast skin thinning and lesion after augmentation mammoplasty by the injection of unknown artificial filler in Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College in July and Novemeber 2021 respectively. With the water-jet force system assisted surgery, the artificial filler scattered in the subcutaneous superficial and partial deeper layers was effectively removed with the impact of water flow, while avoiding the compromise of blood supply and necrosis to the NAC and the breast skin.

Previous studies on adipogenesis mainly focused on induction culture in vitro. With the update of lineage tracing method, combined with the rapid development of single-cell sequencing in recent years, more comprehensive evidences have been obtained on the source and differentiation trajectory of adipocyte lineage in different states in vivo. In this paper, studies on the new-found sources of adipocyte tissue regeneration in vivo are reviewed.

Periodontitis is an inflammatory disease caused by bacterial infection directly, and the dysregulation of host immune-inflammatory response finally destroys periodontal tissues. Current treatment strategies for periodontitis mainly involve mechanical scaling/root planing (SRP), surgical procedures, and systemic or localized delivery of antimicrobial agents. However, SRP or surgical treatment alone has unsatisfactory long-term effects and is easy to relapse. In addition, the existing drugs for local periodontal therapy do not stay in the periodontal pocket long enough and have difficulties in maintaining a steady, effective concentration to obtain a therapeutic effect, and continuous administration always causes drug resistance. Many recent studies have shown that adding bio-functional materials and drug delivery systems upregulates the therapeutic effectiveness of periodontitis. This review focuses on the role of biomaterials in periodontitis treatment and presents an overview of antibacterial therapy, host modulatory therapy, periodontal regeneration, and multifunctional regulation of periodontitis therapy. Biomaterials provide advanced approaches for periodontal therapy, and it is foreseeable that further understanding and applications of biomaterials will promote the development of periodontal therapy.

Cancer cell membrane (CCM) derived nanotechnology functionalizes nanoparticles (NPs) to recognize homologous cells, exhibiting translational potential in accurate tumor therapy. However, these nanoplatforms are majorly generated from fixed cell lines and are typically evaluated in cell line-derived subcutaneous-xenografts (CDX), ignoring the tumor heterogeneity and differentiation from inter- and intra- individuals and microenvironments between heterotopic- and orthotopic-tumors, limiting the therapeutic efficiency of such nanoplatforms. Herein, various biomimetic nanoplatforms (CCM-modified gold@Carbon, i.e., Au@C-CCM) were fabricated by coating CCMs of head and neck squamous cell carcinoma (HNSCC) cell lines and patient-derived cells on the surface of Au@C NP. The generated Au@C-CCMs were evaluated on corresponding CDX, tongue orthotopic xenograft (TOX), immune-competent primary and distant tumor models, and patient-derived xenograft (PDX) models. The Au@C-CCM generates a photothermal conversion efficiency up to 44.2% for primary HNSCC therapy and induced immunotherapy to inhibit metastasis via photothermal therapy-induced immunogenic cell death. The homologous CCM endowed the nanoplatforms with optimal targeting properties for the highest therapeutic efficiency, far above those with mismatched CCMs, resulting in distinct tumor ablation and tumor growth inhibition in all four models. This work reinforces the feasibility of biomimetic NPs combining modular designed CMs and functional cores for customized treatment of HNSCC, can be further extended to other malignant tumors therapy.
Animals ; Humans ; Squamous Cell Carcinoma of Head and Neck/therapy* ; Heterografts ; Photothermal Therapy ; Biomimetics ; Disease Models, Animal ; Head and Neck Neoplasms/therapy* ; Cell Line, Tumor ; Tumor Microenvironment