Gap junction,a special structure in cell membrane,constitutes the only direct communication channel of energy,material and information exchange between adjacent cells.Gap junction plays an important role in the maintenance of electrical activity of neurons,the rapid synchronization of neurons and neuronal development.Epilepsy,caused by a variety of causes,is a complex clinical syndrome.The pathogenesis of epilepsy is complex.And it's still not fully understood.Studies in recent years have found that gap junction plays a very important role in the pathogenesis and development of epilepsy.The structure,distribution and functions of gap junction and the relationship between gap junction and epilepsy are reviewed in the paper.

The author took the medical records of ZHANG Jing-yue,a famous doctor of Ming dynasty,as an example,by analyzing his methods of syndrome differentiation and prescription,and believed that the significance of syndrome difierentiation based on Yin-yang of five viscera in clinical treatment.The key point of TCM treatment is to restore the state of Yin and Yang in a relative equilibrium by enhancing and regulating the functions offive viscera,and so thus to increase the functions of body self-regulating and disease-preventing.

Mycoplasma pneumoniae is a common cause of pediatric community-acquired pneumonia.It has been associated with various extrapulmonary manifestations.Pediatric mycoplasma pneumoniae encephalitis is the most common neurologic manifestations.Direct invasion,an immune-mediated mechanism,or neurotoxin production has been proposed.Because mycoplasma pneumoniae encephalitis has a high mortality and a high rate of neurological sequelae,improving the clinicians awareness of the disease,minimizing misdiagnosis and missed diagnosis,have important significance.

Lu Zhaolin professor thinks,at present,according to the efficacy of traditional Chinese medicine classification method is not conducive to a comprehensive understanding and grasp of the knowledge of traditional Chinese medicine in clinical application.Understanding of the efficacy of traditional Chinese medicine,we should start from the overall regulation of drugs on the human body,and make full use of the theory closely related to traditional Chinese medicine properties such as the four properties and five tastes,ascending-descending-floating-sinking,medicinal guide,etc.Meanwhile the modern pharmacological research achievements should be taken to accurately grasp the efficacy of traditional Chinese medicine.

Improving the innovation ability of students is always concerned by the educators in the modern times.In the paper,the problem of how to train the innovation ability of students in the experiments of Instrument Analysis is discussed from the following five aspects:course innovation,expending the thinking,strengthening the experiment skills,creating the innovation environment and exchanging the experiences.

Objective:To evaluate the effect to treatment adherence of defaulter action implement for patients with Tuberculosis in Chongqing and explore a proper cure management system to timely find out the TB patients who stop picking medicine on time;Methods:Carrying out intervention method to TB patients with positive sputum in intervention counties,then using qualitative study to analysis the effect of implementing the intervention;Results:After the intervention,the adherence of TB patients is obviously improved;Conclusion:Proposed method is a effective and feasible management to the TB patients who stop picking medicine during anti-TB treatment,which bring positive effect on TB patients' adherence and TB cure rate.

Objective To analyze the conditions of antithrombotic therapy in patients with atrial fibrillation (AF)and provide reference for clinical rational use of drugs.Methods The clinical data of 1 69 hospitalized patients with AF from July 201 4 to September 201 4 in Beijing Tongren Hospital affiliated to Capital Medical University were retrospectively analyzed.The risk stratification for thromboembolism,types of AF,drug selection,drug combination and adverse reactions were analyzed.Results In 1 69 patients with AF,the proportion of valvular AF was 1 4.20%(24 /1 69)and non -valvular AF was 85.80%(1 45 /1 69),the patients with AF aged over 60 years old accounted for 84.62%.In the antithrombotic therapy,warfarin accounted for 94.87% (74 /78),the average daily dosage was (2.51 4 ±0.842)mg,the cases with INR between 2.0 to 3.0 accounted for 41 .89%(31 /74).The incidence rate of adverse reactions was 2.56%(2 /78).Conclusion The antithrombotic therapy is obviously insufficient,the clinical pharmacists should analyze the factors which influence the treatment and promote the rational use of antithrombotic therapy in AF patients.

This study was aimed to investigate the dose-response relations and synergy effects of bioactive components in Ginkgo bilobaon antiplatelet aggregation and DPPH free radical scavenging.The antiplatelet aggregation experiment and DPPH free radical scavenging experiment were conducted respectively to investigate the dose-response relations and synergy effects.Firstly,the effect of inhibiting platelet aggregation induced by PAF of ginkgolides in rabbits was investigated.And then,the effect of DPPH free radical scavenging by ginkgo flavonoids was also investigated.Finally,the synergy effects among effective components were studied.The results showed that ginkgolide A,ginkgolide B,ginkgolide C and bilobalide had dose-response relations on antiplatelet aggregation.Quercetin,kaempferol and isorhamnetin had DPPH free radical scavenging effects with dose-response relation.It was concluded that ginkgolide had the dose-response relation on antiplatelet aggregation.Ginkgolide A and ginkgolide B had synergy effect.Ginkgo flavonoids had DPPH free radical scavenging effect.Quercetin and isorhamnetin had synergy effect.

Objective:To explore the significance of blood dialysis device for real-time monitoring of dialysate temperature.Methods: Nikkiso DBB-27-type hemodialysis device was selected as a subject for discussion, analyzed and discussed the working principle, main structure and functional characteristics of the mixture ratio of dialysate and temperature monitor and combined with one case of temperature troubleshooting case.Results: Temperature monitoring was essential to ensure the stable running of dialysate mixture ratio and the temperature of the dialysate.Conclusion: The dialysate temperature has an important effect on renal fibrosis in end-stage hemodialysis patients, it is necessary to monitor the dialysate temperature and mixture ratio. Dialysis device heating degas proportioning system through surveillance system linked to the dialysis unit normal, stable operation, provide safe and reliable dialysis treatment for patients.

Exosomes are vesicles of endocytic origin released from different cell types under both normal and pathological conditions.Proteomics is an emerging discipline for studying composition and mechanics and interac-tion of proteins with regard to disease occurrence、cellular metabolism,etc.Progress of research on exosomes from tumor cell at proteomics technology platforms in aspect of clarifying mechanisms of shaping and sustaining micro-enviroment of tumor growth and survival and metastasis, induce tumor proliferation, Immunosuppressive effects or immune evasion, and discovering biomarker, makes a promising prospect of exsomes in clinical diagnosis and treatment.