P2 receptors are divided into two subclasses:P2X receptors which are ligand-gated ion channels and P2Y receptors which are G-protein coupled. Several kinds of P2X and P2Y receptor subtypes express in vascular endo-thelial cells and vascular smooth muscle cells. Purinergic signalling plays an important role in vascular diseases such as atherosclerosis, cerebral vessels ageing and blood vessel remodeling. So this signalling pathway may pro-vide a new target to treat vascular diseases.

P2 receptors are divided into two subclasses:P2X receptors which are ligand-gated ion channels and P2Y receptors which are G-protein coupled.Several kinds of P2X and P2Y receptor subtypes express in vascular endothelial cells and vascular smooth muscle cells.Purinergic signalling plays an important role in vascular diseases such as atherosclerosis,cerebral vessels ageing and blood vessel remodeling.So this signalling pathway may provide a new target to treat vascular diseases.