OBJECTIVE To analyze the risk factors,clinical characteristics and prevention countermeasures of(nosocomial) fungal infection in patients with acute leukemia.METHODS To adopt investigation way to review and analyze the clinical data of nosocomial fungal infection in 39 cases from 178 acute leukemia inpatients.RESULTS The(nosocomial) fungal infection rate was 21.91%.The nosocomial fungal infection rate in elderly group was(higher) than that of younger group,and in granulocytosis group(≥0.5?10~9/L) was higher than that of

According to different biological functions, breast cancer can be divided into triple-negative breast cancer and non-triple-negative breast cancer. The former has stronger proliferation and invasion ability and faster metastasis. Its immune tissue indicators are estrogen receptor (estrogen receptor, ER) and progesterone receptor. Both the body (progesterone receptor,PR) and human epidermal growth factor 2 receptor (human epidermal growthFactor receptor, HER2) are negative. Surgery and radiotherapy are traditional therapies for TNBC, but these therapies have many side effects and poor prognosis. In order to better prevent the spread and treatment of TNBC, it is particularly important to study the growth, proliferation and apoptosis mechanisms of cancer cells. In recent years, studies have shown that a variety of signaling pathways, lncRNA, and miRNA all affect the growth process of TNBC. In recent years, studies have shown that a variety of signaling pathways, lncRNA, and miRNA all affect the growth process of TNBC. This article reviews domestic and foreign studies on the relevant regulatory mechanisms of TNBC cell proliferation and apoptosis, aiming to clarify the importance of breast cancer cell proliferation and apoptosis pathways, and provide new ideas for drug development for TNBC targeted therapy.

Objective:To investigate the improvement effect of cognitive psychotherapy on negative emotions and shame in patients with cancer and depression.Methods:A total of 114 patients with cancer and depression who received treatment at Shaoxing 7 th People's Hospital from February 2022 to May 2023 were included in this randomized controlled study. The patients were randomly divided into two groups: group A and group B, with 57 patients in each group. Group A received routine western medicine treatment, while group B received routine western medicine combined with cognitive psychotherapy. Both groups received treatment for 8 weeks. Various measures were evaluated at the end of the treatment period, including negative emotions (Hamilton Depression Scale score, Hamilton Anxiety Scale score), shame (Social Impact Scale score), self-efficacy (Breastfeeding Self-Efficacy Scale score), sleep quality (Pittsburgh Sleep Quality Index score), and clinical efficacy. Results:After treatment, the Hamilton Depression Scale score and Hamilton Anxiety Scale score in group B were (7.83 ± 2.01) points and (9.78 ± 1.94) points, respectively, which were significantly lower than those in group A [(12.15 ± 2.37) points, (13.06 ± 2.32) points, t = 10.50, 8.19, both P < 0.001). The Social Impact Scale score in group B was significantly lower than that in group A [(44.72 ± 4.93) points vs. (51.63 ± 6.10) points, t = 6.65, P < 0.001]. The Breastfeeding Self-Efficacy Scale score in group B was significantly higher than that in group A [(121.65 ± 11.44) points vs. (100.24 ± 10.73) points, t = -10.31, P < 0.001]. The Pittsburgh Sleep Quality Index score in group B was significantly lower than that in group A [(7.00 ± 0.85) points vs. (9.83 ± 1.10) points, t = 15.37, P < 0.001]. The overall response rate in group B was significantly higher than that in group A [94.74% (54/57) vs. 80.70% (46/57), χ2 = 5.21, P = 0.022]. Conclusion:Cognitive psychotherapy has a significant impact on patients with cancer and depression, effectively alleviating negative emotions and shame, enhancing self-efficacy, and improving sleep quality. Therefore, it deserves clinical promotion.

Objective To investigate the value of cine magnetic resonance(MR) in determination of cardiac function by using four chamber/multiple slice multiple phase(4CH/MSMP) sequence.Methods In 18 healthy subjects, several indices of left ventricular function were measured by using cine MR 4CH/MSMP sequence, and the correlation of the results was compared with ultrasound cardiography by t test.Results In the measurement of left ventricular short diameter, left ventricular posterior wall thickness, internal ventricular septum thickness, left ventricular end diastolic and end systolic volume, the values of cine MR 4CH/MSMP sequence correlated well with those of echocardiography. The γ value was between 0.88 and 0.99.Conclusion The cine MR 4CH/MSMP sequence may be considered an important noninvasive modality for accurate assessment of cardiac function.

Objective:To evaluate the efficacy and safety of hypomethylating agents (HMA) in patients with myelodysplastic syndromes (MDS) .Methods:A total of 409 MDS patients from 45 hospitals in Zhejiang province who received at least four consecutive cycles of HMA monotherapy as initial therapy were enrolled to evaluate the efficacy and safety of HMA. Mann-Whitney U or Chi-square tests were used to compare the differences in the clinical data. Logistic regression and Cox regression were used to analyze the factors affecting efficacy and survival. Kaplan-Meier was used for survival analysis. Results:Patients received HMA treatment for a median of 6 cycles (range, 4-25 cycles) . The complete remission (CR) rate was 33.98% and the overall response rate (ORR) was 77.02%. Multivariate analysis revealed that complex karyotype ( P=0.02, OR=0.39, 95% CI 0.18-0.84) was an independent favorable factor for CR rate. TP53 mutation ( P=0.02, OR=0.22, 95% CI 0.06-0.77) was a predictive factor for a higher ORR. The median OS for the HMA-treated patients was 25.67 (95% CI 21.14-30.19) months. HMA response ( P=0.036, HR=0.47, 95% CI 0.23-0.95) was an independent favorable prognostic factor, whereas complex karyotype ( P=0.024, HR=2.14, 95% CI 1.10-4.15) , leukemia transformation ( P<0.001, HR=2.839, 95% CI 1.64-4.92) , and TP53 mutation ( P=0.012, HR=2.19, 95% CI 1.19-4.07) were independent adverse prognostic factors. There was no significant difference in efficacy and survival between the reduced and standard doses of HMA. The CR rate and ORR of MDS patients treated with decitabine and azacitidine were not significantly different. The median OS of patients treated with decitabine was longer compared with that of patients treated with azacitidine (29.53 months vs 20.17 months, P=0.007) . The incidence of bone marrow suppression and pneumonia in the decitabine group was higher compared with that in the azacitidine group. Conclusion:Continuous and regular use of appropriate doses of hypomethylating agents may benefit MDS patients to the greatest extent if it is tolerated.