1. Long-term results of multicenter study based on childhood acute lymphoblastic leukemia 2005 protocol
Jiaoyang CAI ; Ningling WANG ; Hui JIANG ; Shuhong SHEN ; Huiliang XUE ; Jing CHEN ; Ci PAN ; Yijin GAO ; Lirong SUN ; Xiaojun YUAN ; Longjun GU ; Jingyan TANG
Chinese Journal of Pediatrics 2018;56(7):511-517
Objective:
To evaluate the long-term efficacy and prognostic factors of childhood acute lymphoblastic leukemia (ALL) enrolled in Shanghai Children's Medical Center-Acute Lymphoblastic Leukemia-2005(SCMC-ALL-2005) multicenter study.
Methods:
Between May 2005 and December 2014, 1 497 newly diagnosed ALL patients were enrolled and treated in 5 hospitals of SCMC-ALL-2005 study group, using risk-stratified SCMC-ALL-2005 protocol. Risk group classification and treatment intensity were based on clinical features, genetic abnormalities, early response to treatment and levels of minimal residual disease (MRD). Kaplan-Meier method was used to generate overall survival (OS) and event-free survival(EFS) curves. Cox proportional hazards models were used for multivariate analyses.
Results:
The patients were followed up to December 31, 2016, the median follow-up time was 69 months (24-141 months). The 5-year and 10-year OS rates were (80.0±1.0)% and (76.0±2.0)%. The 5-year and 10-year EFS rates were (69.0±1.0)% and (66.0±2.0)%. The 5-year and 10-year relapse rates were (23.0±1.0)% and (25.0±2.0)%. The 5-year OS and EFS for low risk (LR), intermediate risk (IR) and high risk (HR) were (91.1±1.4)% and (83.3±1.8)%, (79.2±1.5)% and (68.9±1.7)%, (52.9±4.4)% and (30.0±3.8)%, respectively. MRD negative status (<0.01%) on day 55 was seen in 792 patients (82.8%) and positive MRD on day 55 was associated with poor prognosis (
2. Disinfection efficacy of peracetic acid disinfectant (type Ⅲ) on gastrointestinal endoscopy
Jiaoyang GU ; Lan LIU ; Yu XIN ; Jingmin REN ; Li WANG ; Nan ZHANG ; Honglei WU ; Xingfeng LIN ; Jianqiang GUO
Chinese Journal of Digestive Endoscopy 2019;36(10):741-745
Objective:
To evaluate the disinfection efficacy of peracetic acid disinfectant (type Ⅲ ) on gastrointestinal endoscopy.
Methods:
Endoscopes were disinfected respectively by 2% glutaraldehyde (GA group) and peracetic acid disinfectant (type Ⅲ ) (PAA group) according to the process by the 2016 version of "Regulation for cleaning and disinfection technique of flexible endoscope" , and then samples were collected through biopsy channel at the specified steps. The bacterial count and pathogenic bacteria of these samples were detected. Hepatitis B virus surface antigen (HBsAg), hepatitis C virus (HCV) antibody and