[Objective]To explore the medication rules of Professor HONG Min,a famous traditional Chinese medicine practitioner in Guangdong Province,for treating insomnia.[Methods]The prescriptions of Professor HONG Min for treating insomnia in clinical practice were collected and sorted out,and data mining and analysis were conducted on the frequency of medication,four properties,five flavors,meridian tropism,prescription patterns,potential new formulas and so on by using the Traditional Chinese Medicine Inheritance Support System Platform.[Results]A total of 509 formulas and 180 Chinese herbs were screened out.The top five Chinese herbs in terms of frequency of use were Semen Ziziphi Spinosae Preparata,Rhizoma Pinelliae Preparatum,Radix Glycyrrhizae Preparata,Poria cocos and Radix Scutellariae.The high-frequency herb combinations included Rhizoma Pinelliae Preparatum-Semen Ziziphi Spinosae Preparata,Radix Glycyrrhizae Preparata-Rhizoma Pinelliae Preparatum,Rhizoma Pinelliae Preparatum-Poria cocos,Radix Glycyrrhizae Preparata-Semen ziziphi spinosae Preparata,Poria cocos-Semen ziziphi spinosae Preparata,Rhizoma Pinelliae Preparatum-Radix Scutellariae,Citri Reticulatae Pericarpium-Poria cocos and so on.Seven potential new formula combinations were also obtained.[Conclusion]Professor HONG Min's treatment of insomnia is mainly based on soothing the liver and calming the mind,clearing heat and drying dampness,strengthening the spleen and resolving phlegm.In clinical practice,she pays attention to the theory of five movements and six Qi combined with the theory of six meridians differentiation.She is good at flexibly applying the theory of Zang fu tonification and purgation,balancing multiple organs simultaneously.She also pays attention to integrating constitution,movement of Qi,pathogenesis,human nature,heaven nature and disease nature,comprehensively regulating and treating them to achieve harmony between Yin and Yang and curing insomnia.