1.Negative association of FGA gene 128C/G polymorphism with cerebral infarction and its effect on plasma fibrinogen in Hunan Hans.
Wen-ping GU ; Xiao-ming SONG ; Jiao-e GONG ; Jing LIANG ; Hui XIAO ; Chun-liu TANG ; Rong-zheng DONG ; Qi-dong YANG
Chinese Journal of Medical Genetics 2010;27(3):286-289
OBJECTIVETo investigate the relationship of FGA gene 128C/G polymorphism and cerebral infarction (CI) and evaluate the effect of FGA-128C/G polymorphism on plasma fibrinogen in Hunan Hans.
METHODSFGA-128C/G polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing in 194 CI patients and 114 healthy controls.
RESULTSThere were CG and CC genotypes in the FGA-128C/G locus. No GG genotype was observed in Hunan Hans. There was no significant difference in genotype and allele frequencies between the controls and CI group (P> 0.05), and statistically significant difference was not found in fibrinogen (Fg) level between the CG and CC genotypes (P>0.05). After analyzing blood plasma Fg using the influencing factor multiple regression analysis, it was shown that the Fg level had no relationship with the FGA-128C/G genotype, but it increased with age. And the Fg level in males was higher than that in females.
CONCLUSIONThere was FGA gene 128C/G polymorphism in the Hunan Han population. There was no association of this polymorphism with the increased Fg level of CI patient in the population. FGA-128C/G might not be the predisposing gene of CI in Hunan Han population. The age and sex were the major factors affecting the plasma Fg level in this population.
Aged ; Asian Continental Ancestry Group ; genetics ; Cerebral Infarction ; genetics ; Female ; Fibrinogen ; genetics ; Gene Frequency ; genetics ; Genetic Predisposition to Disease ; genetics ; Genotype ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Genetic ; genetics ; Polymorphism, Restriction Fragment Length
2.Nursing of 17 patients with pregnancy-associated fulminant type 1 diabetes and intrauterine fetal demise
Jiao TANG ; Ling-Ling GAO ; Shu-Hong LIU ; Chun-Miao WEN ; Dong-E GONG ; Xi-Ling HU
Chinese Journal of Nursing 2017;52(7):812-815
This paper retrospectively summarized and analyzed observation of the disease and nursing care of 17 patients with pregnancy-associated fulminant type 1 diabetes and intrauterine fetal demise.Through timely supplying blood capacity and improving renal perfusion,maintaining blood glucose homeostasis and acid-alkali,potassium balance,safety of the patients was guaranteed;by providing effective psychological nursing,puerperal dietary guidance and discharge guidance,patients' rehabilitation was improved.As a result,16 patients were in stable condition,and dead babies were delivered.Major bleeding event occurred in one patient after delivering the dead baby,and the patient developed shock as well as liver and kidney failure.The patient was transferred to ICU for further treatment and became stable and was discharged after two months.
3.Research Strategies and Key Problems Analysis over Substance Benchmark of Famous Classical Formulas
Yan LIU ; Jun ZHANG ; Lin-yong YANG ; Guo-yuan ZHANG ; Shu-yu XU ; Ling-mei KONG ; Xiao-dan QI ; Yun GONG ; Feng-yan NI ; Yan TONG ; An LIU
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(1):1-9
With continuous introduction of relevant national policies on famous classical formulas, the research of famous classical formulas is popular all over the country. Different from other new drugs, in the research and development process of famous classical formulas, substance benchmark is earlier than the product, suggesting that the research and development of substance benchmark is of great significance. Based on previous work of the authors, content of substance benchmark of famous classical formulas was analyzed, which was included in the document