Objective To evaluate the safety and efficacy of percutaneous nephrolithotomy with semirigid ureteroscopic lithotripsy in semisupine-lithotomy position for treatment of encrusted ureteral stents . Methods Patients were placed in semisupine-lithotomy position .The bladder stones and ureteral encrusted stones were treated with ureteroscopy , and then percutaneous holmium laser nephrolithotomy was used to break and wash out the renal pelvis stones and renal new stones . Results The stone fragmentation and stent removal were completed in one session in all 5 cases without conversion to open surgery .The mean operative time was 65 min (range, 40-130 min).No massive hemorrhage, ureteral avulsion, or ureteral perforration occurred during the operation .Two cases had postoperative fever without sepsis .No patients had ureteral stricture or recurrent calculus within follow-ups for 3 -6 months. Conclusion Percutaneous nephrolithotomy combined with semirigid ureteroscopic lithotripsy in semisupine-lithotomy position for treatment of encrusted ureteral stents is safe and effective , being worthy of clinical promotion .

[This corrects the article DOI: 10.1016/j.apsb.2019.01.003.].

Scavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active not only conferred cytoprotection of HO-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, exhibited higher cytoprotective and neuroprotective potential and Overall, our findings showed compound could emerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment.