Objective To study the relation between the stepwise compound medication dosage suggested by NAHC antihypertension protocol and the blood pressure classification in patients with hypertension. Methods 439 of patients with grade 2 & 3 hypertension taken NAHC antihypertension medication protocol for 2 weeks were selected as the subjects, thereinto, 211 male patients aged 51.74?11.56 yrs and 228 females aged57.56?10.78 yrs. The NAHC antihypertension protocol included Nifedipine (N), Atenolol (A), Hydrochlorothiazide (H) and Captopril (C) stepwise dosage as N: 3.75, 7.5, 15.0, 20.0 mg/d; A: 6.25, 12.5, 25.0 mg/d; C: 6.25, 12.5, 25.0 mg/d, the dosage should be adjusted according to the blood pressure and pulse. But the dosage of H was fixed 6.25 mg per day as essential medicine for antihypertension. The medication dosage and blood pressure of patients were observed during the trial. Result After teated with the NAHC protocol, all patients' blood pressure could be controlled between 123～135/79～85 mm Hg, which was in or near uplimit of normal blood pressure range. Both systolic and diastolic pressure were significantly decreased (P

Objective To compare the clinical effects, complications, and aesthetic effect between fusiform incision flap translocation method and horizontal folds micro-incision subcutaneous trimming method for tragomachalia. Methods A total of 40 patients were treated by fusiform incision flap translocation method, but 102 patients by horizontal folds micro-incision subcutaneous trimming method. The follow-up for 6 months was carried out after operation. Results The clinical effective rates by the two methods was 100%. The complication rates were 17.5% and 15.7%, respectively. There was no significant statistical difference between the two methods. However, the aesthetic effect of the horizontal folds micro-incision subcutaneous trimming method was better than that of fusiform incision flap translocation method. Conclusion Horizontal folds micro-incision subcutaneous trimming method is good for tragomachalia with the advantages of satisfactory clinical effect and good aesthetic appearance.

Atherosclerosis is a multifactorial disease and mediated by chronic inflammation from initiation to progression. Inflammatory factors of this process, such as C-reactive protein, interleukin-6, cell adhesion molecules and tumor necrosis factor-a, not only involve in atherosclerosis-related disease process, but also indicate the risk of cardiovascular events. Inflammatory factors level plays a significant role in diagnosis, treatment and prognosis of atherosclerosis-related disease, such as acute coronary syndrome. Recent studies have shown that there is a marked inflammatory response after stenting, which plays an important role in the vascular remodeling process, especially in-stent restenosis. Therefore, it is necessary to explore the molecular mechanism and pathological changes in the process of inflammation and to study prevention and treatment of the inflammation. We believe that inflammatory processes will be new targets of therapy in preventing or treating atherosclerosis and its complications.

Objective To explore whether the anti-apoptotic effect of connective tissue growth factor on human hypertrophic scar fibroblasts is mediated by phosphatidylinositol 3-kinase/protein kinase B(PI3K/PKB)signal pathway.Methods The cultured human hypertrophic scar fibroblasts were divided into three groups:control group,connective tissue growth factor(10 ng/ml)stimulated group,the group pretreated with PI3K inhibitor LY294002(10 ?mol/L)and stimulated with connective tissue growth factor.Levels of phosphorylated PKB were examined by Western blotting in human hypertrophic scar fibroblasts that were stimulated with connective tissue growth factor for 30 min.Flow cytometry was used to detect the apoptosis ratio of the cells.Results Compared with the control group,the apoptosis ratio of the connective tissue growth factor stimulated group decreased(P

0.05). Conclusions The antihypertensive effects of NAHC treatment program could keep the patients' blood pressure in the ideal range.

Objective To discuss the therapeutic effect of fracture operation on multiple bone injuries. Methods The patients with fractures were treated with 3 different methods, ie, emergency, selective and conservative treatments. Early complications such as acute respiratory distress syndrome (ARDS),fat embolism syndrome (FES),duration in insive care unit and mortality rate were compared with the long-term complications of fractures so as to evaluate the curative effect of 3 different methods on multiple bone injuries. Results Among 91 cases (ISS≥30), one died and 2 resulted in FES. Mortality rate, short-term and long-term complications and mean ICU duration were reduced significantly in the emergency treatmentgroup compared with the other two groups ( P

The quality control of medical links runs through the whole process of medical service. Through the identification, management and quality control of key medical links, such as the system of making ward rounds by three levels of doctors, perioperational control, emergency treatment, writing of medical records, medical safety control, and management of critically ill patients, the entire staff's awareness of medical quality has been enhanced, the overall medical quality has been improved and sound social and economic benefits have been attained.

Objective To know the currently prevalent genotype of rotavirus strains in Ningbo City,which will help to the study of vaccine of group A rotavirus.Methods The VP7 fragments were amplified by RT-PCR and sequence analysis was conducted from 2 of the 11 virus strains.Results VP7 amino acid sequences homogeneity of the two strains Ningbo 06-1 and Ningbo 06-3 was 90.2%.They all shared higher amino acid sequences homogeneity with G1 strain Wa(95.1% and 87.7%,respectively)than with other serotypes(G types)rotavirus(

Objective To explore an effective and hidden incision scar method for epicanthus correction. Methods 80 patients of bi-lateral single eyelid with epicanthus were divided into group A,group B and group C. Twenty-five patients with 50 eyes of group A received“Z” plasty correction of epicanthus,25 cases with 50 eyes of group B received the traditional“Y-V” plasty correction of epicanthus,30 cases with 60 eyes of group C treated with modified “Y-V” plasty correction of epicanthus. The curative effective was observed. Results Three groups were followed up for 6~24 months, the appearances of 25 patients in group A were significantly improved,of whom 2 cases had uni-lateral recurrence,8 cases with obvious postoperative scar. The eyelid shapes of patients in group B were natural after surgery,12 cases with obvious scar. all patients in group C were found no postoperative hypertrophic scars. Conclusion The three surgical treatment were effec-tive for epicanthus,but the design approaches of“Z” plasty correction and“Y-V” plasty correction are more complex,and postoperative scar is obvious,meanwhile the modified “Y-V” plasty correction is simple with incision hidden good shape scar formation.

Objective To explore the signal mechanism of proliferation stimulating effect of connec-tive tissue growth factor (CTGF) on hypertrophic scar (HS) derived fibroblasts. Methods <'3>H-TdR in-corporation technique was used to determine the proliferative effect of CTGF at different concentration. Western blot was applied to semi-quantitively analyze the expression of phosphorylated and total ERK1/2 protein after 0, 5, 10, 15, 30, and 60 min of CTGF stimulation, and the relative value of which was de-fined as AI to measure the activation of ERK1/2 signal pathway. PD98059 was admitted to specifically block the ERK1/2 pathway, and subsequently cell proliferation stimulated by CTGF was studied by MTT. Results CTGF could stimulate fibroblasts proliferation with a dose-dependant manner, and activa-ted the ERK1/2 signal pathway, and AI built up to 0.209±0.0201, reaching the apex at 15 min after stimulation performed. Inhibition of ERK1/2 activation by PD98059 suppressed CTGF-mediated HS fi-broblasts proliferation significantly, while OD significantly dropped. Conclusion CTGF induces a prolif-erative response in HS fibroblasts, and this action is mainly dependent on the activation of ERK1/2 signal pathway.