Objective To investigate the relationship between peri-menopausal women blood lipid level and the gallstone disease in order to provide theoretical basis for the prevention of gallbladder stone.Methods Seventy-two patients with gallbladder calculus from Department of Hepatobiliary Surgery Jinshan District Central Hospital of Shanghai and 52 healthy women coming for physical examination as the control group.Participants were divided into five age groups (20-29,30-39,40-49,50-59 and 60-69 years old) and two age stages (young period (30-40 years old) and peri-menopausal period (45-55 years old)),total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL-C),low-density lipoproteins (LDL-C) and Body Mass Index (BMI) were determined and compared between the stone group and the control group at different age stages.Results In comparison of the menopausal transition period,the stone group had significantly lower blood TC,HDL-C and LDL-C levels than the control group (TC:(4.58 ± 0.27) mmol/L vs.(5.15 ± 0.26) mmol/L,t=3.112,P ＜0.01 ;HDL-C:(1.17 ±0.11) mmol/L vs.(1.40 ±0.08) mmol/L,t =3.351,P ＜0.01 ;LDL-C:(2.71 ± 0.30) mmol/L vs.(3.15 ± 0.26) mmol/L,t =2.437,P ＜ 0.05).For the young period,there were no significant difference on blood lipid level and BMI was observed between the stone group and the control group (P ＞ 0.05).The fat HDL-C level in blood was significantly lower in the stone group in the menopausal transition period than in the young period ((1.17 ± 0.11) mmol/L vs.(1.33 ± 0.07) mmol/L,t =2.455,P ＜ 0.05).The control group had significantly higher peri-menopausal TC,TG,LDL-C levels in blood and BMI than those in the control group young period (P ＜ 0.05) ; And HDL-C level,no significant difference (TC:(5.15 ± 0.26)mmol/L vs.(4.47 ± 0.34) mmol/L,t =3.175,P ＜ 0.01 ; TG:(1.88 ± 0.39) mmol/L vs.(1.10 ± 0.24)mmol/L,t=3.066,P＜0.01;LDL-C:(3.15 ±0.26) mmol/L vs.(2.71 ±0.31) mmol/L,t =2.261,P＜0.05;BMI:(24.75±0.99) kg/m2vs.(21.73±1.11) kg/m2,t=4.217,P＜0.01).Conclnsion For perimenopausal (45-55 years old) females,decline of serum TC,HDL-C and LDL-C levels may be related to the formation of cholesterol stone.Lower HDL-C level is closely associated with formation of cholesterol stone,indicating that it may be one of the measures to prevent gallbladder stone by adjusting blood fat in perimenopausal women.

Objective:To study the effect of auricular point pressing beans combined with Zusanli point sticking on the recovery of gastrointestinal function in patients after gynecological laparoscopic surgery.Methods:From June 2019 to November 2019, 110 patients who underwent laparoscopic surgery under general anesthesia for hysteromyoma and ovarian cyst in Ningbo Women and Children Hospital and recovered after surgery were selected in the study.They were randomly divided into the experimental group( n=55) and the control group( n=55) by random number table method.The control group was given routine nursing after laparoscopic operation.The observation group was given auricular point pressing beans before surgery combined with Zusanli acupoint sticking after operation to promote the recovery of gastrointestinal function.The time of postoperative bowel sound recovery, the time of the first postoperative anal exhaust, and the incidence of postoperative vomiting and abdominal distension were compared between the experimental group and the control group. Results:The recovery time of bowel sounds after laparoscopy in the observation group was (16.33±2.48)h, which was significantly shorter than that in the control group[(25.50±2.20)h], and the first anal exhaust time in the observation group was (21.22±2.45)h, which was significantly shorter than that in the control group[(32.17±2.09)h], the differences were statistically significant( t=19.59, 24.06, all P<0.05). The incidence of postoperative vomiting in the observation group was 5.45%, which was significantly lower than 21.82% in the control group, and the incidence of abdominal distension in the observation group was 10.91%, which was significantly lower than 32.73% in the control group, and the differences were statistically significant(χ 2=19.59, 24.06, all P<0.05). Conclusion:In gynecological laparoscopic surgery, the application of auricular point pressing beans combined with Zusanli point sticking after operation can promote the early recovery of gastrointestinal function, which is worthy of popularizing.

A case of pituicytoma was observed in a Han-Wistar rat from the control group of a 2-year carcinogenicity study. No obvious abnormality were found in clinical observation and necropsy. Hematoxylin and Eosin (HE) staining results showed that nodular hyperplasia in the pars nervosa of the pituitary, which was well demarcated and compressed the adjacent normal tissue. The tumor cells were similar to the glial cells with round or oval nuclei, cytoplasm rich in eosinophilic or vacuole. The tumor cells differentiated well, with no obvious cell pleomorphism and visible mitotic figures. Some tumor cells were arranged in a pseudorosette formation. Immunohistochemical staining (IHC) analysis confirmed positive expression of Glial fibrillary acidic protein (GFAP) and S-100 protein. The tumor was diagnosed as the spontaneous benign pituicytoma combining the HE and IHC staining results.