Objective:To evaluate the effects of ulinastatin on inflammatory response and liver and kidney functions after chest operation.Methods:Forty patients who received chest operation were randomly divided into two groups as test group(20) and control group(20).For the test group,we use 300 000 unit ulinastatin respectively 1 day before and 1,2,3 days after the operation.For the control group,we use the physiological saline at the same time.We detected IL-6,IL-8,FN and TNF-? levels and functions of several viscera by measuring aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TB),Scr,BUN,Cr pre-operation and 1 d,3 d,5 d and 7 d post-operation.Results: In the operation group,the levels of IL-6, IL-8 and TNF-? were lower than those of patients in the control group at 1 d,3 d,5 d,and 7 d after operation.The levels of ALT,AST,and TB of patients in the test group were lower than those of patients in the control group at 1 d, 3 d,and 5 d after operation.The liver and kidney function recovered to normal in the test group 7 d post operation.Conclusion: Ulinastatin has protective effect during the recovery of patient's liver and kidney functions after chest surgery.The results confirmed that ulinastatin can enhance the body's tolerance to surgery stress by suppressing the secretion of harmful cytokines.

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Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties, including the bones and teeth in vertebrates. The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues. In particular, the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization. Here, we review recent advances in biomineralization-inspired materials developed for hard tissue repair. Biomineralization-inspired materials are categorized into different types based on their specific applications, which include bone repair, dentin remineralization, and enamel remineralization. Finally, the advantages and limitations of these materials are summarized, and several perspectives on future directions are discussed.
Biomineralization