1.Insights for multi-site physician practice
Jiansheng ZUO ; Lin JI ; Mao LIN
Chinese Journal of Hospital Administration 2013;29(12):885-887
Western developed countries have already made multi-site physician practice a mainstream in their physicians'regulatory system,which remains however at the beginning stage in China during the ongoing health reform since 2009.This article justified the significance of this practice,then analyzed its main roadblocks encountered in China,and in the end proposed countermeasures in terms of better awareness,better policy support and practicality of the practice.
2.Study on the clinical characteristics of severe acute respiratory syndrome(SARS )in elderly patients
Haicong LI ; Xiaoguang CHEN ; Xiaolin TONG ; Bin ZHANG ; Jiansheng MAO
Chinese Journal of Geriatrics 1995;0(02):-
ObjectiveTo elucidate the clinical characteristics and the outcome of SARS in elderly pat ients. Methods Clinical data of 66 elderly patients(≥60 years) with SARS were analysed and compared with that of 238 younger adult SARS patients(18-59 years) in the sa me period. Results Sixty-six out of 304 patients(21 7%) with SARS were more than 60 years. Th e mortality rate of SARS in elderly patients was 22 7%. Underlying disease,lon ger course of disease,dyspneic respiration,severe type of SARS,and higher mor tality were more prevalent in elderly patients than those in the younger adult S ARS patients(P
3.Misdiagnosis of 3 adult liver hamartomas.
Jiansheng MAO ; Yuexiang CHEN ; Xingrong ZHANG
Chinese Journal of Hepatology 2002;10(6):478-478
Adult
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Aged
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Diagnostic Errors
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Female
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Hamartoma
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diagnosis
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Humans
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Liver
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pathology
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Liver Diseases
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diagnosis
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Liver Neoplasms
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diagnosis
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Male
4.The effects of nourishing lung and kidney formulas on inflammatory response of alveolar epithelial cells stimulated by monocytes conditioned medium
Yanqin QIN ; Haoran DONG ; Jiansheng LI ; Yulong CHEN ; Xiaoning MAO ; Mingming WU
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2017;24(1):63-67
Objective To observe the effects of nourishing lung and kidney formulas on inflammatory response of alveolar epithelial cells stimulated by monocytes conditioned medium and study the anti-inflammatory mechanism of the formulas for the treatment of chronic obstructive pulmonary diseases (COPD).Methods The reproduction of inflammation models of A549 cells were stimulated by monocyte THP-1 cell strain conditioned medium.A549 cells were randomly divided into blank control group (20% blank rabbits serum),model group (20% blank rabbits serum+25.0% THP-1 cell conditioned medium),nuclear transcription factor activator protein-1 (AP-1) pathway inhibitor T-5224group (20% blank rabbits serum+25.0% THP-1 cells conditioned medium+100 μmol/L T-5224),nourishing lung and kidney group (20% rabbits serum with nourishing lung and kidney formulas+25.0% THP-1 cells conditioned medium).The contents of interleukins (IL-6,IL-8),tumor necrosis factor-α (TNF-αα),matrix metalloprotein-9 (MMP-9) in cell culture supernatant were detected with enzyme linked immunosorbent assay (ELISA),the supernatant content of malondialdehyde (MDA) was detected with thibabituric acid (TBA) method,the total activity of superoxide dismutase (T-SOD) was detected with hydroxylamine method,and the activity of AP-1 pathway was detected with electrophoretic mobility shift assay (EMSA) method.Results Compared with the blank control group,the A549 cell proliferation were significantly increased at 24 hours,48 hours stimulation by 25.0% cell conditioned medium (A value:24 hours was 0.41 ± 0.02 vs.0.37 ± 0.04,48 hours was 1.30 ± 0.09 vs.1.15 ± 0.19).Compared with the blank control group,the contents of IL-6,IL-8,TNF-αα,MMP-9,MDA,AP-1 expression were significantly increased in model group [IL-6 (ng/L):35.00±3.63 vs.23.15±1.72,IL-8 (ng/L):273.09± 164.36 vs.231.45±33.90,TNF-α(ng/L):51.61 ± 9.51 vs.28.87 ± 3.34,MMP-9 (ng/L):442.85 ± 78.86 vs.235.60 ± 14.62,MDA (μmol/L):6.90 ± 0.11 vs.6.01 ± 0.12,AP-1 expression (A value):2.260 ± 0.062 vs.1.000 ± 0.000],MDA/T-SOD ratio was increased (4.43 ± 0.05vs.3.96 ± 0.06).Compared with model group,the levels of IL-8 (ng/L:100.29 ± 17.03),TNF-α (ng/L:25.13 ± 0.46),AP-1 expression (A value:1.38 ± 0.02),and the MDA/T-SOD ratio (4.23 ± 0.23) in T-5224 group,and MMP-9 (ng/L:195.44±9.80),MDA (μmol/L:5.86±0.30),MDA/T-SOD ratio (3.56±0.41),AP-1 expression (A value:0.76 ± 0.01) in nourishing lung and kidney group were all reduced significantly (all P < 0.05).Conclusion Nourishing lung and kidney formulas can suppress the inflammatory response through regulating the alveolar epithelial cells AP-1 signaling pathways.
5.Primary common bile duct closure after choledochotomy.
Longtang XU ; Zhangdong ZHENG ; Kai CHEN ; Rongjin WU ; Genjun MAO ; Jiansheng LUO ; Jiamin ZHANG ; Hao ZHANG ; Tianding ZENG
Chinese Journal of Surgery 2002;40(12):927-929
OBJECTIVETo investigate the rationality and feasibility of primary closure of the common bile duct after choledochotomy for common bile duct calculi.
METHODSFrom January 1990 to June 2001, 386 patients with the evidence of stones in the common bile duct underwent choledochotomy. Among them, 215 received primary closure of the common bile duct (group A) and 171 T-tube drainage (group B). The patients with emergency operations were excluded. Intraoperative choledochoscopy or cholangiography was routinely performed to rule out the possibility of retained stones. The duct was meticulously stitched using 0/3 to 0/5 absorbent sutures for primary closure. A T-tube was placed in the subhepatic space in the patients of both groups.
RESULTSPostoperative bile leakage was seen in 9 patients of group A and in 5 of group B, respectively (P > 0.05), and no reoperations were necessary. After surgery, the average time and volume of transfusion was 4.9 days and 9.1 liters in group A, versus 7.3 days and 12.8 liters in group B (P < 0.01). The patients in group B had a longer postoperative hospital stay than the those in group A (average 17.6:10.0 days, P < 0.01). T-tube removal resulted in bile peritonitis in 5 patients at day 16, 17, 19, 21 and 22 after surgery in group B, and 3 patients required repeated surgery.
CONCLUSIONSPrimary closure of the common bile duct after choledochotomy is safe, effective, and inexpensive in selected patients with common bile duct calculi, and should be regarded as an alternative procedure.
Adult ; Aged ; Biliary Tract Surgical Procedures ; methods ; Choledocholithiasis ; surgery ; Common Bile Duct ; surgery ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome
6.The Influence of Length-diameter Ratio Difference on Stress Distribution at Dental Bone-Implant Interface
Yulin ZHOU ; Zhihong MAO ; Jiansheng WANG ; Li JIANG
Journal of Medical Biomechanics 2019;34(3):E315-E319
Objective To investigate the differences in stress distribution at the bone-implant interface of dental implants with different length-diameter ratios, so as to provide references for the design of novel dental implants. Methods The three-dimensional finite element model of mandible was established using Geomagic studio, SolidWorks and ANSYS Workbench software. The mandibular molars were applied with different vertical or oblique forces, to compare and analyze stress distributions on dental implants and the surrounding bone tissues. Results Under the same length-diameter ratio, the maximum peak equivalent stress of implant under oblique loading was significantly higher than that under vertical loading. The Von Mises stresses of implants in Group A and Group B occurred in the neck under oblique and vertical loading. Under oblique loading, the implant stress variation in Group A and Group B was 144.74-374.67 MPa and 161.52-475.38 MPa, respectively. Under vertical loading, the implant stress variation in Group A and Group B was 101.28-187.40 MPa and 110.08-210.32 MPa, respectively. The maximum Von Mises stress of Group A was significantly smaller than that of Group B. Conclusions Dentists should focus on a length-diameter ratio of 2.67 to select the standard implants, and the jawbone quality of patients should be taken into full account.
7.Effects of the Extract of Xiongmatang on 5-HT and CGRP in Brain Tissue of Rats with Liver-yang Hyperactivity and Blood Stagnation Migraine
Dingding LIU ; Jing YANG ; Dong LIU ; Jiansheng GUO ; Xiaoxian MAO ; Guirong ZENG ; Ying ZHOU
China Pharmacy 2020;31(1):24-29
ABSTRACT OBJECTIVE:To study the effects of the extract of Xiongmatang on 5-HT and CGRP in brain tissue of rats with liver-yang hyperactivity and blood stagnation migraine. METHODS:Fifty male spontaneously hypertension (SHR) rats were randomly divided into model control group,Zhengtian pill positive control group (1.6 g/kg),the extract of Xiongmatang low-dose,medium-dose and high-dose groups(4.5,9.0,18.0 g/kg,by crude drug),with 10 rats in each group. Another 10 normal rats were taken as normal control group. Administration group was given relevant medicine intragastrically,once a day,for consecutive 28 d. Normal control group and model control group were given equal volume normal saline intragastrically. After last administration,except for normal control group,other groups were used to stimulate trigeminal ganglia(10 min)to establish liver-yang hyperactivity and blood stagnation migraine model,and maintained the administration once more after making the model. 30 min later,general behavior and tongue quality of rats were observed,and the blood pressure was measured;the contents of 5-HT and CGRP in cerebral tissue of rats were determined by ELISA. The protein expression of CGRP in cerebral tissue of rats were determined by Western blot method. RESULTS: Compared with the normal control group, the rats in the model control group had behavioral symptoms,such as the color of conjunctiva deepened and reddened, excessive hairdressing,head flicking,and most of the rats had purple tongue;the systolic pressure and the content and protein expression of CGRP were all increased obviously(P<0.05 or P<0.01), while the content of 5-HT in cerebral tissue was decreased obviously(P<0.01). Compared with model control group,general behavior and tongue quality of rats were improved significantly in administration groups. Systolic pressure,the content and the protein expression of CGRP in cerebral tissue of rats were decreased significantly in Zhengtian pill positive control group and the extract of Xiongmatang high-dose group (P<0.05),while the content of 5-HT in cerebral tissue of rats were increased significantly in Zhengtian pill positive control group,the extract of Xiongmatang medium-dose and high-dose groups(P<0.05).CONCLUSIONS:The extract of Xiongmatang has obvious protective effect on liver-yang hyperactivity and blood stagnation migraine model rats,the mechanism of which may be associated with reducing the content of CGRP in cerebral tissue and raising the content of 5-HT in cerebral tissue
8. Pilot study of the relationship between clinical classification of gallbladder cancer and prognosis: a retrospective multicenter clinical study
Dong ZHANG ; Zhimin GENG ; Chen CHEN ; Yongjie ZHANG ; Yinghe QIU ; Ning YANG ; Desheng WANG ; Xuezhi WANG ; Tianqiang SONG ; Jianying LOU ; Jiangtao LI ; Xianhai MAO ; Wenbin DUAN ; Shengping LI ; Xiangming LAO ; Xiangqian ZHAO ; Yajin CHEN ; Lei ZHANG ; Yudong QIU ; Jiansheng LIU ; Yongyi ZENG ; Wei GONG ; Zhaohui TANG ; Qingguang LIU ; Zhiwei QUAN
Chinese Journal of Surgery 2019;57(4):258-264
Objectives:
To propose a novel clinical classification system of gallbladder cancer, and to investigate the differences of clinicopathological characteristics and prognosis based on patients who underwent radical resection with different types of gallbladder cancer.
Methods:
The clinical data of 1 059 patients with gallbladder cancer underwent radical resection in 12 institutions in China from January 2013 to December 2017 were retrospectively collected and analyzed.There were 389 males and 670 females, aged (62.0±10.5)years(range:22-88 years).According to the location of tumor and the mode of invasion,the tumors were divided into peritoneal type, hepatic type, hepatic hilum type and mixed type, the surgical procedures were divided into regional radical resection and extended radical resection.The correlation between different types and T stage, N stage, vascular invasion, neural invasion, median survival time and surgical procedures were analyzed.Rates were compared by χ2 test, survival analysis was carried by Kaplan-Meier and Log-rank test.
Results:
Regional radical resection was performed in 940 cases,including 81 cases in T1 stage,859 cases in T2-T4 stage,119 cases underwent extended radical resection;R0 resection was achieved in 990 cases(93.5%).The overall median survival time was 28 months.There were 81 patients in Tis-T1 stage and 978 patients in T2-T4 stage.The classification of gallbladder cancer in patients with T2-T4 stage: 345 cases(35.3%)of peritoneal type, 331 cases(33.8%) of hepatic type, 122 cases(12.5%) of hepatic hilum type and 180 cases(18.4%) of mixed type.T stage(χ2=288.60,